Dorsal Root of the Spinal Nerve

2020 ◽  
Author(s):  
Keyword(s):  
Dorsal Root ◽  
Spinal Nerve

Axon repulsion during peripheral nerve segmentation

Development ◽  
1991 ◽  
Vol 113 (Supplement_2) ◽  
pp. 131-139 ◽  
Author(s):  
Roger J. Keynes ◽  
Karen F. Jaques ◽  
Geoffrey M. W. Cook
Keyword(s):  
Dorsal Root ◽  
Grey Matter ◽  
Growth Cones ◽  
Spinal Nerve ◽  
Chick Embryos ◽  
Posterior Half ◽  
Similar Activity ◽  
Sensory Axons ◽  
Axon Repulsion

The guidance of axons during embryonic development is likely to involve both adhesive and repulsive interactions between growth cones and their environment. We are characterising the role and mechanism of repulsion during the segmental outgrowth of motor and sensory axons in the somite mesoderm of chick embryos. Axons are confined to the anterior half of each somite by the expression in the posterior half of a glycoconjugate system (48×103Mr and 55×103Mr) that causes the collapse of dorsal root ganglion growth cones when applied in vitro. Enzymatic cleavage of this fraction with specific combinations of endo- and exoglycosidases removes collapse activity, suggesting that carbohydrate residues are involved in the execution of collapse. A similar activity is also detectable in normal adult grey matter, suggesting roles for repulsion beyond the development of spinal nerve segmentation.

scholarly journals Comparison of histological changes of sensory neurons of Dorsal Root Ganglion of spinal nerve in different age groups in rabbits

2015 ◽  
Vol 39 (2) ◽  
pp. 42-46
Author(s):  
Ali Ghanim Al-Okaili
Keyword(s):  
Dorsal Root Ganglion ◽  
Sensory Neurons ◽  
Light Microscope ◽  
Dorsal Root ◽  
Age Factors ◽  
Age Groups ◽  
Spinal Nerve ◽  
Histological Changes ◽  
Made In

     The aim of the study is to compare the histological changes that occur in the sensory neurons of dorsal root ganglion at L6 and L7 levels of the spinal nerve in different age groups in rabbits. Fifteen rabbits were divided into three groups of equal number according to their age (weaning, maturation and adult). Dorsal root ganglion of spinal nerve at L6 and L7 levels were removed and examined histologically under light microscope. Comparison were made in diameters of neurons and their numbers in different age. The results showed a significant (P<0.05) decrease in the number of sensory neurons and a significant (P<0.05) increase in their diameters with advancing age. In conclusion, the structures of sensory neurons are altering by the age factors in which morphology, number, and color of neurons change also.

Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion

2008 ◽  
Vol 1219 ◽  
pp. 26-31 ◽  
Author(s):  
Megumi Omori ◽  
Masataka Yokoyama ◽  
Yoshikazu Matsuoka ◽  
Hiroyuki Kobayashi ◽  
Satoshi Mizobuchi ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Nociceptive Responses

scholarly journals Contribution of the Suppressor of Variegation 3-9 Homolog 1 in Dorsal Root Ganglia and Spinal Cord Dorsal Horn to Nerve Injury–induced Nociceptive Hypersensitivity

2016 ◽  
Vol 125 (4) ◽  
pp. 765-778 ◽  
Author(s):  
Jun Zhang ◽  
Lingli Liang ◽  
Xuerong Miao ◽  
Shaogen Wu ◽  
Jing Cao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Nerve Injury ◽  
Group Treatment ◽  
Dorsal Root ◽  
Polymerase Chain Reaction Analysis ◽  
Spinal Nerve ◽  
Spinal Cord Dorsal Horn ◽  
Down Regulation ◽  
Neuronal Nuclei

Abstract Background Peripheral nerve injury–induced gene alterations in the dorsal root ganglion (DRG) and spinal cord likely participate in neuropathic pain genesis. Histone methylation gates gene expression. Whether the suppressor of variegation 3-9 homolog 1 (SUV39H1), a histone methyltransferase, contributes to nerve injury–induced nociceptive hypersensitivity is unknown. Methods Quantitative real-time reverse transcription polymerase chain reaction analysis, Western blot analysis, or immunohistochemistry were carried out to examine the expression of SUV39H1 mRNA and protein in rat DRG and dorsal horn and its colocalization with DRG μ-opioid receptor (MOR). The effects of a SUV39H1 inhibitor (chaetocin) or SUV39H1 siRNA on fifth lumbar spinal nerve ligation (SNL)–induced DRG MOR down-regulation and nociceptive hypersensitivity were examined. Results SUV39H1 was detected in neuronal nuclei of the DRG and dorsal horn. It was distributed predominantly in small DRG neurons, in which it coexpressed with MOR. The level of SUV39H1 protein in both injured DRG and ipsilateral fifth lumbar dorsal horn was time dependently increased after SNL. SNL also produced an increase in the amount of SUV39H1 mRNA in the injured DRG (n = 6/time point). Intrathecal chaetocin or SUV39H1 siRNA as well as DRG or intraspinal microinjection of SUV39H1 siRNA impaired SNL-induced allodynia and hyperalgesia (n = 5/group/treatment). DRG microinjection of SUV39H1 siRNA also restored SNL-induced DRG MOR down-regulation (n = 6/group). Conclusions The findings of this study suggest that SUV39H1 contributes to nerve injury–induced allodynia and hyperalgesia through gating MOR expression in the injured DRG. SUV39H1 may be a potential target for the therapeutic treatment of nerve injury–induced nociceptive hypersensitivity.

scholarly journals Effective gene expression in the rat dorsal root ganglia with a non-viral vector delivered via spinal nerve injection

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ming-Fong Chang ◽  
Jung-Hsien Hsieh ◽  
Hao Chiang ◽  
Hung-Wei Kan ◽  
Cho-Min Huang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Viral Vector ◽  
Spinal Nerve
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