scholarly journals Giant Cell Tumor of the Knee. Case Report of a Potentially Aggressive Benign Tumor

2018 ◽  
Vol 3 (1) ◽  
pp. 735-740
Author(s):  
Álvaro Cerda ◽  
Ricardo Tolosa ◽  
Ramón Hernandez
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Benign Tumor ◽  
Signs And Symptoms ◽  
Cell Tumor ◽  
Primary Bone Tumor ◽  
Appropriate Treatment ◽  
Therapeutic Procedures ◽  
Primary Bone ◽  
Third Age Of Life

The giant cell tumor of bone (OCD) is a primary bone tumor that occurs most frequently in the third age of life, being located mainly at the distal femur. The development of a biopsy to establish the diagnosis and to begin appropriate treatment quickly is a fundamental to establish as early as possible surgical resection procedure. In this article a case of TOCG is presented in a patient of 30 years. Its etiology, signs and symptoms, diagnosis, as well as an adequate diagnostic and therapeutic procedures to achieve a positive resolution of this pathology is discussed.

scholarly journals Giant cell tumor of the frontal sinus: case report

2017 ◽  
Vol 3 (3) ◽  
pp. 725 ◽  
Author(s):  
Ali Alzarei ◽  
Majed Assiri ◽  
Rabab N. B. ◽  
Wael Aljoraebi ◽  
Ibrahim Sumaily
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Frontal Sinus ◽  
Frontal Bone ◽  
Cell Tumor ◽  
Primary Bone Tumor ◽  
Histopathological Images ◽  
Primary Bone ◽  
Work Up ◽  
Firm Mass

Giant cell tumor (GCT) is an uncommon aggressive primary bone tumor usually affects long bones. It is rarely involving skull bones, and to less extent the frontal bone. Up to date only 3 adult cases reported of the frontal bone, only one of them was occupying the frontal sinus. Here, we present a 49 year old male presented with slowly growing left supraorbital swelling for 3 years. This swelling was a firm mass with destruction of anterior table of frontal bone. Diagnostic radiological work-up showed a mass in left frontal sinus, mass excised with external approach. Reporting this case with its clinical, radiological and histopathological images should add significant material to the literature for further studies of GCT of paranasal sinuses.

scholarly journals Giant Cell Tumor of Bone, current treatments, and potential therapeutic alternatives

2020 ◽  
pp. 13
Author(s):  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Research Work ◽  
Cell Tumor ◽  
Treatment Modalities ◽  
Malignant Degeneration ◽  
Primary Malignancy ◽  
Primary Bone Tumor ◽  
Advantages And Disadvantages ◽  
Therapeutic Alternatives

Giant cell tumor of bone (GCTB) is a primary bone tumor, locally aggressive. For many, a GCTB is considered a tumor with an unpredictable behavior, particularly regarding recurrences, pulmonary implants, and the possibility of primary malignancy. In terms of risk of recurrence, it is known that it is associated with the type of treatment used initially for the GCTB. The greater the number or recurrences, the greater the risk of pulmonary implants, and the greater the risk of malignant degeneration. Therefore, much of the prognosis of this tumor could be related to the type of initial treatment. Hence the importance of the treatment theme. This review includes a comparison between the various modalities for treatment in GCTB, considering the advantages and disadvantages of each one. Existing GCTB treatments are not 100% safe and effective at the same time. and this is the reason why the search for other treatment modalities should continue to offer a better oncologic and functional outcome to patients. In the end of this review, based on research work, we also mention other possible therapeutic options that could be explored and used in the future for GCT treatment.

Aggressive Osteoclastoma of Sphenoid Sinus: A Rare Surgical Case Report

2016 ◽  
Vol 8 (2) ◽  
pp. 68-71 ◽  
Author(s):  
Narendra Kumar ◽  
G Sundhar Krishnan
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Sphenoid Sinus ◽  
Benign Tumor ◽  
Cell Tumor ◽  
The Body ◽  
Radiological Investigation ◽  
Surgical Case ◽  
Temporal Bones

ABSTRACT The giant cell tumor (GCT) or osteoclastoma is considered to be a locally aggressive benign tumor. The GCTs of the cranium represent only 1% of all GCTs and preferentially affect the sphenoid and temporal bones. We report a case of an 18-year-old male who presented with headache and diplopia. Radiological investigation shows a destructive midline mass involving the body of the sphenoid. The tumor was debulked endoscopically and histopathology reported as osteoclastoma of sphenoid sinus. Radiotherapy and zoledronate was given. We report this case due to its extreme aggressive nature of growth, which is a challenge to treat, and unique presentation in teenaged male, which is rare. How to cite this article Krishnan GS, Kumar N. Aggressive Osteoclastoma of Sphenoid Sinus: A Rare Surgical Case Report. Int J Otorhinolaryngol Clin 2016;8(2):68-71.

scholarly journals Recurrences of giant cell tumor of bone within soft tissue

2020 ◽  
Vol 8 (34) ◽  
pp. 56-60
Author(s):  
Dylan Homen ◽  
George Brindley ◽  
Cody Beaver
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Benign Tumor ◽  
Surgical Intervention ◽  
Cell Tumor ◽  
Adjacent Soft Tissue

Giant cell tumor of bone (GCTB) is typically considered an aggressive but benign tumor, and recurrence of the tumor following surgical intervention is common. It is much rarer, however, for recurrence to occur in the soft tissue surrounding the original lesion. Literature investigating the giant cell tumor of soft tissue is much less prevalent than that of bony recurrence, and our understanding of its etiology is still developing. This report presents two cases in which recurrence of the tumor occurred in the adjacent soft tissue following intralesional excision of GCTB, in hopes of identifying variables that could have contributed to this atypical recurrence and prompting further investigations regarding means of possible prevention.

scholarly journals Characteristics Giant Cell Tumor of The Bone Cases at Dr. Mohammad Hoesin General Hospital Period 1 January 2017 - 31 Augsut 2020

2021 ◽  
Vol 5 (3) ◽  
pp. 546-552
Author(s):  
Primadika Rubiansyah ◽  
Randy Rakhmat Septiandani
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
General Hospital ◽  
Lung Metastases ◽  
Cell Tumor ◽  
Primary Bone Tumor ◽  
Grade Ii ◽  
Male Patients ◽  
Group 2 ◽  
Short Time

Introduction : Giant Cell Tumor (GCT) is a benign bone tumors with potentially aggressive and capacity to metastasize. This tumor could destroy the bone and joint component. As a primary bone tumor that appears at productive age , GCT can cause morbidity for patients. Methods : This research is a retrospective descriptive study with data obtained from the medical records of patients who went to Mohammad Hoesin general hospital for the period January 1, 2017- August 31, 2019. Data processing was carried out using SPSS 16.0. From the research results, 27 GCT patient data that met the inclusion criteria were obtained. Results : There were 23 (85.1%) patients in the 20-44 years age group, 2 (7.4%) people <20 years, 2 (7.4%) people> 44 years. There were 13 (48%) male patients and 14 (52%) female patients. The most common tumor locations were in the proximal tibia as many as 6 (22%) people, Distal Femur as many as 6 (22%) people, Distal Radius as many as 5 (18.5%) people, Distal Ulna as many as 3 (11.1%) people, Proximal Femur as many as 1 (3.7 %) people, Calcaneus as much as 1 (3.7%) people, Metacarpal as many as 1 (3.7%) people. Based on grading Campanacci, 16 (59.25%) people had GCT with Campanacci Grade III, Grade II with 8 (29.6%) people, and 1 (3.7%) grade I. Only 2 (7.4%) people had recurrences. No patients were found to have lung metastases (0%). There were 1 (3.7%) patients with pathological fracture on GCT. Management carried out was 24 people undergoing resection and reconstruction 24 (88.5%) and 3 (11.5%) people with curettage and bone cement. Conclusion : This study of GCTB at Mohammad Hoesin general hospital bring out that patient’s characteristics are similar with other country and theory. Mostly patient got GCTB at age second until fouth decade of life, slightly more in female, mostly tumor detected around the knee. Mostly patient detected with Campanacci graded III and needed resection and reconstruction surgery. No reported lung metastases in GCTB patient but this record need further follow up due to short time between surgery and study

scholarly journals New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRβ Signaling

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3543
Author(s):  
Michal Mahdal ◽  
Jakub Neradil ◽  
Peter Mudry ◽  
Silvia Paukovcekova ◽  
Iva Staniczkova Zambo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Stromal Cells ◽  
Growth Factor Receptor ◽  
Metastatic Potential ◽  
Giant Cells ◽  
Cell Tumor ◽  
Primary Bone Tumor

Giant-cell tumor of bone (GCTB) is an intermediate type of primary bone tumor characterized by locally aggressive growth with metastatic potential. The aim of this study was to identify new druggable targets among the cell signaling molecules involved in GCTB tumorigenesis. Profiles of activated signaling proteins in fresh-frozen tumor samples and tumor-derived cell lines were determined using phosphoprotein arrays. Analysis of the obtained data revealed epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor beta (PDGFRβ) as potential targets, but only the PDGFR inhibitor sunitinib caused a considerable decrease in stromal cell viability in vitro. Furthermore, in the case of a 17-year-old patient suffering from GCTB, we showed that the addition of sunitinib to the standard treatment of GCTB with the monoclonal antibody denosumab resulted in the complete depletion of multinucleated giant cells and mononuclear stromal cells in the tumor tissue. To summarize, the obtained data showed that a specific receptor tyrosine kinase (RTK) signaling pattern is activated in GCTB cells and plays an important role in the regulation of cell proliferation. Thus, activated RTKs and their downstream signaling pathways represent useful targets for precision treatment with low-molecular-weight inhibitors or with other types of modern biological therapy.

scholarly journals Giant cell tumor of soft tissue of hand: simple but rare diagnosis, which is often missed

2011 ◽  
Vol 1 (3) ◽  
pp. 54 ◽  
Author(s):  
Sarwan Kumar ◽  
Lynn F. Carter
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Benign Tumor ◽  
Middle Age ◽  
Lower Extremities ◽  
Cell Tumor ◽  
Rare Entity ◽  
Rare Diagnosis

Giant cell tumor of soft tissue originally described in 1972 in two different series by Salm and Sissons is a rare entity, which is clinically and histopathologically indistinguishable from giant cell tumor of bone. Usually involve thigh, trunk, and lower extremities but rarely involve the hands. GCT-ST is a benign tumor, which can transform into malignant form and also has potential for recurrence and metastasis. We present an otherwise healthy, middle age female who originally presented with swellings on her left finger was diagnosed with giant cell tumor of soft tissue hand.

scholarly journals Characteristics Giant Cell Tumor of The Bone Cases at Dr. Mohammad Hoesin General Hospital Period 1 January 2017 - 31 Augsut 2020

2021 ◽  
Vol 5 (5) ◽  
pp. 493-499
Author(s):  
Primadika Rubiansyah ◽  
Randy Rakhmat Septiandani
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
General Hospital ◽  
Lung Metastases ◽  
Cell Tumor ◽  
Primary Bone Tumor ◽  
Grade Ii ◽  
Male Patients ◽  
Group 2 ◽  
Short Time

Introduction : Giant Cell Tumor (GCT) is a benign bone tumors with potentially aggressive and capacity to metastasize. This tumor could destroy the bone and joint component. As a primary bone tumor that appears at productive age , GCT can cause morbidity for patients. Methods : This research is a retrospective descriptive study with data obtained from the medical records of patients who went to Mohammad Hoesin general hospital for the period January 1, 2017- August 31, 2019. Data processing was carried out using SPSS 16.0. From the research results, 27 GCT patient data that met the inclusion criteria were obtained. Results : There were 23 (85.1%) patients in the 20-44 years age group, 2 (7.4%) people <20 years, 2 (7.4%) people> 44 years. There were 13 (48%) male patients and 14 (52%) female patients. The most common tumor locations were in the proximal tibia as many as 6 (22%) people, Distal Femur as many as 6 (22%) people, Distal Radius as many as 5 (18.5%) people, Distal Ulna as many as 3 (11.1%) people, Proximal Femur as many as 1 (3.7 %) people, Calcaneus as much as 1 (3.7%) people, Metacarpal as many as 1 (3.7%) people. Based on grading Campanacci, 16 (59.25%) people had GCT with Campanacci Grade III, Grade II with 8 (29.6%) people, and 1 (3.7%) grade I. Only 2 (7.4%) people had recurrences. No patients were found to have lung metastases (0%). There were 1 (3.7%) patients with pathological fracture on GCT. Management carried out was 24 people undergoing resection and reconstruction 24 (88.5%) and 3 (11.5%) people with curettage and bone cement. Conclusion : This study of GCTB at Mohammad Hoesin general hospital bring out that patient’s characteristics are similar with other country and theory. Mostly patient got GCTB at age second until fouth decade of life, slightly more in female, mostly tumor detected around the knee. Mostly patient detected with Campanacci graded III and needed resection and reconstruction surgery. No reported lung metastases in GCTB patient but this record need further follow up due to short time between surgery and study

Giant Cell Tumor of the Metatarsal

Foot & Ankle ◽  
1988 ◽  
Vol 8 (4) ◽  
pp. 223-226 ◽  
Author(s):  
Thomas P. Burns ◽  
Mark Weiss ◽  
Mark Snyder ◽  
Clark N. Hopson
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Cell Tumor ◽  
Giant Cell Tumors ◽  
En Bloc ◽  
Primary Bone Tumors ◽  
Metatarsal Bones ◽  
Primary Bone

The following is a report of a giant cell tumor of a metatarsal, description of treatment, and review of the literature. Giant cell tumors comprise approximately 5–8% of the primary bone tumors. Metatarsal bones are a very rare primary site of involvement. Clinically aggressive or benign behavior cannot be predicted histologically. Treatment should be aggressive, as in this case where en bloc resection and bone graft were performed. Results were excellent with 4 yr follow-up.

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