scholarly journals The Effect of Vitamin D Supplementation on the Increase in CD4 count of HIV/AIDS Patients Receiving Antiretroviral Therapy

2020 ◽  
Vol 5 (1) ◽  
pp. 144-147
Author(s):  
Mega Permata ◽  
Harun Hudari ◽  
Mediarty ◽  
Taufik Indrajaya
Keyword(s):  
Vitamin D ◽  
Cell Count ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Antiretroviral Drugs ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Cd4 Cell ◽  
Hiv Aids

Introduction. Vitamin D plays a role in health overall, but hypovitaminosis D stilloccurs throughout the world. HIV/AIDS patients are prone to suffer fromhypovitaminosis D because of the infection itself and the side effects of antiretroviraltherapy. Various effort have been tried to improve the immune status of HIV/AIDSpatients, one of them is by adding vitamin D. Vitamin D acts as an antiinflammatoryso that it can prevent apoptosis of CD4 T cells and increase CD4 cell count.Methods. This is a randomized control trial add on a study that aims to determinethe effect of vitamin D to increase in CD4 counts of HIV / AIDS patients who havereceived antiretroviral drugs. Subjects were HIV / AIDS patients who had receivedantiretroviral drugs. A total of 20 subjects were divided randomly into two groups;one group received vitamin D (calcitriol 0.5 mcg per day) for eight weeks, and theother group that received a placebo. Each group was measured of CD4 cell countbefore and after treatment. Results. There was a significant increase in the CD4 cellcount of the vitamin D group (p = 0.046), but not in the CD4 cell count of bothgroups (p = 0.985). The comparison of mean CD4 cell counts between groups beforetreatment was not significantly different (p = 0.057), but after treatment, it becamesignificantly different (p = 0.040). Conclusion. Vitamin D has been successful inincreasing CD4 cell count in the vitamin D group, and it is recommended to giveHIV / AIDS patients to increase CD4 cell count.

Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/AIDS patients in Yunnan, China

2019 ◽  
Vol 59 (3) ◽  
pp. 308-313 ◽  
Author(s):  
Yu‐Ye Li ◽  
Shi‐Han Yang ◽  
Rui‐Rui Wang ◽  
Jun‐Ting Tang ◽  
Hong‐Mei Wang ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
Hiv Aids

scholarly journals Seroprevalence Toxoplasma Infection among HIV/AIDS Patients in Kathmandu, Nepal

2021 ◽  
Vol 23 (1) ◽  
pp. 72-75
Author(s):  
Swatantra Bhandari ◽  
S KC ◽  
L Devkota ◽  
S Khadka ◽  
G Rai ◽  
...  
Keyword(s):  
Toxoplasmic Encephalitis ◽  
Serum Samples ◽  
Toxoplasma Infection ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
National Public Health ◽  
Threatening Condition ◽  
Cd4 Cell ◽  
Hiv Aids

Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii affecting about one third of the world’s population. It can be asymptomatic to fatal toxoplasmic encephalitis depending on the immune status of infected individuals. Among HIV/AIDS patients, it usually manifest as life-threatening condition. We, therefore, studied the seroprevalence of T. gondii infection among HIV/AIDS patients in Nepal and this report constitutes the first report from Nepal. A total of 45 HIV/AIDS patients were included in this study. The serum samples collected and stored at -20°C were tested for Toxoplasma IgG and IgM antibodies at National Public Health Laboratory, Teku, Kathmandu using Snibe Maglumi 1000 Fully Automated Immunoassay Analyzer and the results were expressed in AU/ml. The blood put into the EDTA tube was used for CD4 count using BD FACS Calibur Flow Cytometer. In this study, 33.3% (15/45) HIV infected patients were seropositive for anti-T. gondii IgG. However, none of them were positive to anti- T. gondii IgM. Most of the patients (36 out of 45 patients) had <200/mm3 CD4 cell count. However, out of them 36.1% (13/36) were seropositive to anti-T. gondii IgG whereas 22.2% (2/9) patients with ≥200 CD4 cell counts had Toxoplasma antibodies (p >0.05).

scholarly journals Effects of Probiotics on Diarrhea and CD4 Cell Count in People Living With HIV: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiao-Li Zhang ◽  
Ming-Hui Chen ◽  
Shi-Tao Geng ◽  
Juehua Yu ◽  
Yi-Qun Kuang ◽  
...  
Keyword(s):  
Fixed Effects ◽  
Meta Analysis ◽  
People Living With Hiv ◽  
Preventive Strategy ◽  
Fixed Effects Model ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Cd4 Cell ◽  
Hiv Aids

Gastrointestinal probiotics play an important role in maintaining intestinal bacteria homeostasis. They might benefit people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), which remains a global health challenge. However, there is a controversy regarding the efficacy of probiotics for the treatment of AIDS. This study systematically reviewed the evidence of the effects of existing probiotic interventions on AIDS and sought to provide information on the role of probiotics in the treatment of HIV/AIDS patients. A meta-analysis of studies identified by screening multiple databases was performed using a fixed-effects model in Review Manager 5.2 software. The meta-analysis showed that probiotics could reduce the incidence of AIDS-related diarrhea (RR = 0.60 (95% CI: 0.44–0.82), p = 0.001). The short-term use of probiotics (supplementation duration shorter than 30 days) did not reduce the incidence of diarrhea (RR = 0.76 (95% CI: 0.51–1.14), p = 0.19), while the long-term use of probiotics (supplementation duration longer than 30 days) reduced diarrhea (RR = 0.47 (95% CI: 0.29–0.76), p = 0.002). Probiotics had no effect on CD4 cell counts in HIV/AIDS patients (MD = 21.24 (95% CI: −12.95–55.39), p = 0.22). Our data support that probiotics were associated with an obvious reduction in AIDS-related diarrhea, which indicates the need for additional research on this potential preventive strategy for AIDS.

scholarly journals A Stochastic Model for Assessing the Efficacy of Antiretroviral Therapy (ART) on Farmers Living with HIV/AIDS

2019 ◽  
Vol 1 ◽  
pp. 247-258
Author(s):  
P O Agada ◽  
B B Apeagee ◽  
I O Ogwuche
Keyword(s):  
Markov Chain ◽  
Cell Count ◽  
Poor Health ◽  
Health States ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Patient Will ◽  
Cd4 Cell ◽  
Hiv Aids

The Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) remains one of the greatest public health challenges still facing Nigeria and the entire world as it has become drug resistant in some patients. Hence, treatment failure and spread of drug resistant HIV/AIDS results. In view of this, it becomes imperative to assess the efficacy of the Antiretroviral Therapy (ART) treatment and hence the life expectancy of the HIV/AIDS patients. This was achieved in this study via a stochastic model based on the Markov chain modelling methodology. The CD4 cell counts of a sample of 28,582 patients (farmers) receiving treatment every six (6) months at the HIV counselling and Testing (HCT) unit of the Federal Medical Centre Makurdi, Benue State was used in the modelling process. The CD4 cell count states were developed based on the United States Centres for Disease Control and Prevention (CDC) classification system as follows; State 1: CD4 cell counts ≥ 500 cells/μL, State 2: CD4 cell count in the range of 200 – 499 cells/ μL, and State 3: CD4 cell count < 200 cells/ μL. They represent the Good, Moderate and Poor health states of the patients respectively. The HIV/AIDS progression in the study was investigated using The N-Step transition probability Matrix of the Markov Chain while, the efficacy of the ART was examined from one CD4 cell count state to another using the Steady State probabilities of the Markov Chain as well as the Mean Recurrence Time of each CD4 count state. The study result shows that; the initial probabilities that a patient will stay in the good, moderate, and poor health states in the first six (6) months of the ART are; 0.834, 0.333 and 0.280 respectively. The overall efficacy of the ART showed a 78%, 19%, and 3.3% chances that a patient will be in the Good, Moderate and Poor health states respectively with respective mean recurrence times of 0.64, 2.69 and 14.99 years. Further results shows that the total life expectancy of patients in the good and moderate health states are 20.425 and 19.275 years respectively. The study recommends that the methodology be applied to a cohort study to further validate study these results.

scholarly journals Enhanced Oxidative Stress Markers and Antioxidant Imbalance in HIV Infection and AIDS Patients

2009 ◽  
Vol 1 (2) ◽  
pp. 370-380 ◽  
Author(s):  
P. Pasupathi ◽  
T. Ramchandran ◽  
P. J. Sindhu ◽  
G. Saranavan ◽  
G. Bakthavathsalam
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Hiv Infection ◽  
Cell Count ◽  
Antioxidant Status ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Control Subjects ◽  
Cd4 Cell ◽  
Hiv Aids

The aim of this study was to investigate lipid peroxidation as evidenced by thiobarbutric acid reactive substances (TBARS), ceruloplasmin (Ce), CD4+ cells counts and antioxidant, and micronutrients status in HIV infection and AIDS patients. The level of plasma and erythrocyte TBARS, plasma ceruloplasmin was markedly increased in the AIDS patients when compared to HIV infection and healthy control subjects. We observed a significant reduction in CD4+ cell count in HIV/AIDS patients when compared to control subjects. The activities of erythrocyte antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and reduced glutathione (GSH), were significantly decreased in AIDS patients when compared with HIV infection and healthy subjects. Significantly low levels of plasma GSH, vitamin A (β-carotene), vitamin C, vitamin E, serum uric acid, albumin, selenium and zinc were also observed in AIDS patients when compared with HIV positive patients and control subjects. The study highlights the occurrence of lipid peroxidation and possible breakdown of antioxidant status in HIV/AIDS patients, which may subsequently increase the possibility of poor immunity. The antioxidant status was progressively depleted in HIV infected persons as the disease progressed from a symptomatic state to AIDS.Keywords: Oxidative stress; HIV; AIDS; CD4+ cell count; Antioxidant status.© 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.DOI: 10.3329/jsr.v1i2.2295

scholarly journals Profile of antiretroviral and its outcome on patients with HIV-AIDS in Wamena Public Hospital

2019 ◽  
Author(s):  
Erwin Astha Triyono ◽  
Stefania Rany Seran ◽  
Didik Hasmono
Keyword(s):  
Cell Count ◽  
Clinical Condition ◽  
Public Hospital ◽  
Adverse Drug Events ◽  
Healthcare Services ◽  
Antiretroviral Drugs ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
Hiv Aids

In Papua, HIV/AIDS is characterized as a widespread epidemic, with a prevalence of 2.3% and a case rate of 416.91 per 100.000. The low accessibility of healthcare services is a major challenge for health services in Papua. The purpose of this study was to determine the profile of ARV use and therapy outcomes of HIV/AIDS patients at Wamena Public Hospital in Papua. This research is an observational cross-sectional retrospective study. Data was collected from the medical records of 236 patients who met the inclusion criteria. Study showed that FDC (TDF + 3TC + EFV) is the most frequently used ARV. ARV therapy improved the clinical condition of 14 patients, and 9 patients had a worsening of their clinical condition. There was an increase in CD4 cell count after 6, 12, and 24 months of ARV therapy in 76%; 55%; and 72% of patients. There were 55 adverse drug events that required a change of regimen. Based on this study, the use of antiretroviral drugs improved clinical condition, decreasing the number of IO, and increasing the patient's CD4 cell count.

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