scholarly journals Profile of antiretroviral and its outcome on patients with HIV-AIDS in Wamena Public Hospital

2019 ◽  
Author(s):  
Erwin Astha Triyono ◽  
Stefania Rany Seran ◽  
Didik Hasmono
Keyword(s):  
Cell Count ◽  
Clinical Condition ◽  
Public Hospital ◽  
Adverse Drug Events ◽  
Healthcare Services ◽  
Antiretroviral Drugs ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
Hiv Aids

In Papua, HIV/AIDS is characterized as a widespread epidemic, with a prevalence of 2.3% and a case rate of 416.91 per 100.000. The low accessibility of healthcare services is a major challenge for health services in Papua. The purpose of this study was to determine the profile of ARV use and therapy outcomes of HIV/AIDS patients at Wamena Public Hospital in Papua. This research is an observational cross-sectional retrospective study. Data was collected from the medical records of 236 patients who met the inclusion criteria. Study showed that FDC (TDF + 3TC + EFV) is the most frequently used ARV. ARV therapy improved the clinical condition of 14 patients, and 9 patients had a worsening of their clinical condition. There was an increase in CD4 cell count after 6, 12, and 24 months of ARV therapy in 76%; 55%; and 72% of patients. There were 55 adverse drug events that required a change of regimen. Based on this study, the use of antiretroviral drugs improved clinical condition, decreasing the number of IO, and increasing the patient's CD4 cell count.

scholarly journals The Effect of Vitamin D Supplementation on the Increase in CD4 count of HIV/AIDS Patients Receiving Antiretroviral Therapy

2020 ◽  
Vol 5 (1) ◽  
pp. 144-147
Author(s):  
Mega Permata ◽  
Harun Hudari ◽  
Mediarty ◽  
Taufik Indrajaya
Keyword(s):  
Vitamin D ◽  
Cell Count ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Antiretroviral Drugs ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Cd4 Cell ◽  
Hiv Aids

Introduction. Vitamin D plays a role in health overall, but hypovitaminosis D stilloccurs throughout the world. HIV/AIDS patients are prone to suffer fromhypovitaminosis D because of the infection itself and the side effects of antiretroviraltherapy. Various effort have been tried to improve the immune status of HIV/AIDSpatients, one of them is by adding vitamin D. Vitamin D acts as an antiinflammatoryso that it can prevent apoptosis of CD4 T cells and increase CD4 cell count.Methods. This is a randomized control trial add on a study that aims to determinethe effect of vitamin D to increase in CD4 counts of HIV / AIDS patients who havereceived antiretroviral drugs. Subjects were HIV / AIDS patients who had receivedantiretroviral drugs. A total of 20 subjects were divided randomly into two groups;one group received vitamin D (calcitriol 0.5 mcg per day) for eight weeks, and theother group that received a placebo. Each group was measured of CD4 cell countbefore and after treatment. Results. There was a significant increase in the CD4 cellcount of the vitamin D group (p = 0.046), but not in the CD4 cell count of bothgroups (p = 0.985). The comparison of mean CD4 cell counts between groups beforetreatment was not significantly different (p = 0.057), but after treatment, it becamesignificantly different (p = 0.040). Conclusion. Vitamin D has been successful inincreasing CD4 cell count in the vitamin D group, and it is recommended to giveHIV / AIDS patients to increase CD4 cell count.

scholarly journals Relationship Between Adherences of Antiretroviral (ARV) Consumption with Viral Load in HIV/AIDS

2021 ◽  
Vol 5 (1) ◽  
pp. 300-305
Author(s):  
Indah Jayani ◽  
Susmiati Susmiati ◽  
Yudied Agung Mirasa ◽  
Khusnul Khotimah
Keyword(s):  
Viral Load ◽  
Sampling Technique ◽  
Antiretroviral Drugs ◽  
P Value ◽  
Load Testing ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
The Relationship ◽  
Hiv Aids

Viral load testing is an informative and sensitive method for successful HIV / AIDS therapy. This study aims to determine the relationship between adherence to viral antiretroviral consumption and viral load in people with HIV/AIDS. This research is a correlational analytic study using a cross-sectional approach. The population in this study was 34 people and, the number of samples was 32 using the purposive sampling technique. The research sample in this study was 32 respondents. The test results using the Spearman Rank obtained p-value 0,00 > 0,05. It was concluded that there was a relationship between adherence to antiretroviral drugs and viral load. Advice for people with HIV / AIDS  is expected to increase adherence to ARV consumption so that viral load is low and undetectable so that CD4 cell count increases and disease prognosis improves.

scholarly journals Hubungan Jumlah Cluster of Differentiation 4 (CD4) dengan Infeksi Oportunistik Pada Pasien HIV/AIDS di Rumah Sakit Umum Daerah (RSUD) DOK II Jayapura

2018 ◽  
Vol 7 (1) ◽  
pp. 16-21
Author(s):  
Mirna Widiyanti ◽  
Hotma Hutapea
Keyword(s):  
Cell Count ◽  
Opportunistic Infection ◽  
Opportunistic Infections ◽  
Chi Square ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Chi Square Test ◽  
Cd4 Cell ◽  
The Relationship ◽  
Hiv Aids

Human Immunodeficiency Virus (HIV) is an infection that attacks and weakens the immune system. HIV infection causes a decrease in the number of Cluster Differentiation 4 (CD4) thereby increasing the progression of the disease and lead to high risk of opportunistic infections (OI). The purpose of this study was to examine the relationship between CD4 cell count with opportunistic infections in patients infected with HIV/AIDS. Analytical research methods using cross-sectional design, by taking medical records. The population in this study were 67 patients with HIV/AIDS in the VCT Clinic Dok II Hospital Jayapura 2014. Data were processed with the Chi Square test hypotheses. Based on the results of hypothesis testing of 67 patients, there were 21 people have opportunistic infections. Tuberculosis is an opportunistic infection that is most common (17.9%). Significance of the relationship seen in the low CD4 counts (< 350 cells/mm3) and found value of 0.02 (CI 95%) which indicates that there is a relationship if p<0.05. Conclusion: there is a relationship between CD4 cell count with opportunistic infections.Key words: CD4, opportunistic infection, HIV/AIDS, hospital.

scholarly journals Haematological Changes in Peripheral Blood of HIV – Infected Persons with Correlation to CD4 Cell Count

2015 ◽  
Vol 32 (3) ◽  
pp. 130-136 ◽  
Author(s):  
Md Mizanur Rahman ◽  
Susane Giti ◽  
Md Saiful Islam ◽  
Md Mostafizur Rahman
Keyword(s):  
Cell Count ◽  
Peripheral Blood ◽  
Flow Cytometric Analysis ◽  
Armed Forces ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Flow Cytometric ◽  
Erythrocyte Sedimentation ◽  
Haematological Changes ◽  
Cd4 Cell

Objective: Aims at recognizing the haematological abnormalities in peripheral blood associated with HIV infection and to correlate the haematological abnormalities with CD4 cell count to highlight these manifestations with disease progression.Methodology: Observational cross sectional study.Setting: Department of Haematology, Armed Forces Institute of Pathology (AFIP), Dhaka cantonment.Patients: Two hundred four (204) HIV – infected patients receiving antiretroviral therapy aged from three years to 65 years. There were 132 male and 72 female patients.Results: Anaemia was found in 103 (50.5%) cases. Leucopenia and thrombocytopenia were observed in ten (4.9%) and seven (3.4%) cases respectively. Lymphopenia was found in 12 (5.9%) cases. In 50 (24.5%) cases Erythrocyte Sedimentation Rate (ESR) was > 20 mm at the end of 1st hour. Flow cytometric analysis for CD4 cell count showed < 200 cells/cmm in 65 (31.8%) cases, in between 200 cells/cmm and 499 cells/cmm in 117 (57.4%) cases and > 500 cells/cmm in 22 (10.8%) cases.Conclusion: Haematological abnormalities are common in HIV – infected patients and responsible for significant morbidity and mortality in these patients. These abnormalities are more frequent with disease progression. The present study revealed a significant increase in the number of anaemia, leucopenia, lymphopenia and thrombocytopenia with decreasing CD4 cell count.J Bangladesh Coll Phys Surg 2014; 32: 130-136

Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/AIDS patients in Yunnan, China

2019 ◽  
Vol 59 (3) ◽  
pp. 308-313 ◽  
Author(s):  
Yu‐Ye Li ◽  
Shi‐Han Yang ◽  
Rui‐Rui Wang ◽  
Jun‐Ting Tang ◽  
Hong‐Mei Wang ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
Hiv Aids

Initiation of highly active antiretroviral therapy in advanced AIDS with CD4 < 50 cells/mm3 in a resource-limited setting: efficacy and tolerability

2005 ◽  
Vol 16 (3) ◽  
pp. 243-246 ◽  
Author(s):  
Somnuek Sungkanuparph ◽  
Sasisopin Kiertiburanakul ◽  
Weerawat Manosuthi ◽  
Wiphawee Kiatatchasai ◽  
Asda Vibhagool
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Highly Active Antiretroviral Therapy ◽  
Adverse Drug Events ◽  
Opportunistic Infections ◽  
Transcriptase Inhibitor ◽  
Cd4 Cell Count ◽  
Hiv Rna ◽  
Highly Active ◽  
Cd4 Cell

In developing countries, patients often present late with advanced AIDS and a very low CD4 cell count. A retrospective cohort study was conducted in HIV-infected patients who had been initiated into highly active antiretroviral therapy (HAART) with CD4 cell count <50 cells/mm3. There were 159 patients of mean age 36.6 years and 60.4% had previous major opportunistic infections. Mean CD4 was 22 cells/mm3 and 80% had HIV RNA>100,000 copies/mL. The majority of HAART regimens is non-nucleoside reverse transcriptase inhibitor-based (81.8%). In as-treated analysis, 50, 71.2, 79.7, 79.4, and 80.1% of patients achieved undetectable HIV RNA (<50 copies/mL) at 12, 24, 36, 48, and 60 weeks, respectively. The corresponding mean CD4 counts were 95, 125, 166, 201, and 225 cells/mm3. Twenty two patients (13.8%) had adverse drug events and half of these had to discontinue HAART. Initiation of HAART in advanced AIDS with CD4 cell count <50 cells/mm3 is effective, safe, and well tolerated and should not be delayed.

scholarly journals CD4 count and oral health related quality of life of HIV-infected individuals at a tertiary healthcare center in Dharan – A cross-sectional study

2017 ◽  
Vol 13 (4) ◽  
pp. 392-396
Author(s):  
Ashish Shrestha ◽  
Jyotsna Rimal ◽  
Nimesh Poudyal
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Cell Count ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Related Quality ◽  
Tertiary Healthcare ◽  
Cd4 Cell

Background & Objective:  Patients with severe immuno-suppression are at risk of having poor oral hygiene and severe periodontal diseases, thus limiting their quality of life. The objective of this study was to assess the impact of oral health-related quality of life (OHRQoL) in patients with HIV/AIDS and its association with the CD4 cell count.Materials & Methods:  A cross-sectional study was conducted using Oral Health Impact Profile-14 (OHIP-14) among 122 HIV/AIDS patients visiting the CD4 laboratory at a tertiary healthcare center at Dharan, from January-December 2009. Oral examination and recording of dental indices were done. CD4 cell count was correlated with OHIP-14 and dental indices using Spearman’s rho; p < 0.01 was considered as statistically significant.Results:  Sixty four males and 58 females with median age of 34 years had a mean CD4 cell count of 360.46 cells/mm3 (range=111-1076 cells/mm3). OHRQoL was affected in 25.4% of the individuals with mean OHIP-14 score of 2.5. Most of the individuals (85.7%) were on ART, never used tobacco (68%) or alcohol (74.5%). Mean OHI-S and DMFT were 1.65 and 1.57, respectively and periodontal pocket observed in only 3.3% individuals. The CD4 cell count had no significant positive correlation with OHIP-14 ((rs=0.071; p=0.61), OHI-S (rs=0.21; p=0.127) and DMFT (rs=0.015; p=0.912). There was no significant difference in parameters with regards to gender.Conclusion: Although CD4 cells are an important indicator for clinical aggravation of HIV infection, OHRQoL and oral health as measured by OHI-S, DMFT and CPI are not directly associated to the CD4 cell count.

scholarly journals A Stochastic Model for Assessing the Efficacy of Antiretroviral Therapy (ART) on Farmers Living with HIV/AIDS

2019 ◽  
Vol 1 ◽  
pp. 247-258
Author(s):  
P O Agada ◽  
B B Apeagee ◽  
I O Ogwuche
Keyword(s):  
Markov Chain ◽  
Cell Count ◽  
Poor Health ◽  
Health States ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Patient Will ◽  
Cd4 Cell ◽  
Hiv Aids

The Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) remains one of the greatest public health challenges still facing Nigeria and the entire world as it has become drug resistant in some patients. Hence, treatment failure and spread of drug resistant HIV/AIDS results. In view of this, it becomes imperative to assess the efficacy of the Antiretroviral Therapy (ART) treatment and hence the life expectancy of the HIV/AIDS patients. This was achieved in this study via a stochastic model based on the Markov chain modelling methodology. The CD4 cell counts of a sample of 28,582 patients (farmers) receiving treatment every six (6) months at the HIV counselling and Testing (HCT) unit of the Federal Medical Centre Makurdi, Benue State was used in the modelling process. The CD4 cell count states were developed based on the United States Centres for Disease Control and Prevention (CDC) classification system as follows; State 1: CD4 cell counts ≥ 500 cells/μL, State 2: CD4 cell count in the range of 200 – 499 cells/ μL, and State 3: CD4 cell count < 200 cells/ μL. They represent the Good, Moderate and Poor health states of the patients respectively. The HIV/AIDS progression in the study was investigated using The N-Step transition probability Matrix of the Markov Chain while, the efficacy of the ART was examined from one CD4 cell count state to another using the Steady State probabilities of the Markov Chain as well as the Mean Recurrence Time of each CD4 count state. The study result shows that; the initial probabilities that a patient will stay in the good, moderate, and poor health states in the first six (6) months of the ART are; 0.834, 0.333 and 0.280 respectively. The overall efficacy of the ART showed a 78%, 19%, and 3.3% chances that a patient will be in the Good, Moderate and Poor health states respectively with respective mean recurrence times of 0.64, 2.69 and 14.99 years. Further results shows that the total life expectancy of patients in the good and moderate health states are 20.425 and 19.275 years respectively. The study recommends that the methodology be applied to a cohort study to further validate study these results.

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