scholarly journals Effect of Probiotics on Parkinson's Disease Rating, Selected Gastrointestinal Measurements and Oxidative Stress Parameters in Parkinson’s Disease: A Systematic Review of Randomized Controlled Trials

2021 ◽  
Vol 0 (0) ◽  
pp. 1-20
Author(s):  
Elif Sina Atak ◽  
◽  
Dilara Yıldız ◽  
Rümeysa Rabia Kocatürk ◽  
Arzu Temizyürek ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Controlled Trials ◽  
Gastrointestinal System ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Disease Rating

Introduction: Parkinson's disease is the world's second most prevalent neurological disease. In Parkinson’s disease intracytoplasmic neuronal inclusions are observed in enteric neurons in the gastrointestinal tract, and the composition of the intestinal microbiome is altered. These changes correlate with the motor phenotype. A systematic review was conducted to determine the effect of probiotics with individuals with Parkinson’s disease. Methods: Scopus, PubMed, Web of Science, The Cochrane Library, Science Direct and OVID-LWW were searched until April 2021 and total 27.395 records were reached according to inclusion and exclusion criteria with the following outcomes: Parkinson's disease rating; oxidative stress, and gastrointestinal system markers. Data searches, article selection and data extraction assessments were performed according to the PRISMA guidelines. The Jadad scale was used to rate the evidence's quality. Results: The information gathered from 5 randomized controlled trials involving 350 individuals with Parkinson’s disease receiving probiotic supplements. Parkinson’s disease rating and non-motor symptoms test were performed. Oxidative stress (Glutathione, malondialdehyde) and gastrointestinal system symptoms (bowel opening frequency, gut transit time, complete bowel movement, spontaneous bowel movements) were evaulated for 4-12 weeks of usage. Conclusion: While all high-quality studies demonstrate progress, there is currently insufficient data to recommend the use of probiotics for people with Parkinson's disease in clinical practice.

scholarly journals Additional Physical Interventions to Conventional Physical Therapy in Parkinson’s Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

2020 ◽  
Vol 9 (4) ◽  
pp. 1038 ◽  
Author(s):  
Ruben D. Hidalgo-Agudo ◽  
David Lucena-Anton ◽  
Carlos Luque-Moreno ◽  
Alberto Marcos Heredia-Rizo ◽  
Jose A. Moral-Munoz
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Physical Therapy ◽  
Randomized Controlled Trials ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Balance Confidence ◽  
Randomized Controlled

Parkinson’s disease (PD) represents the second most common neurodegenerative disease. Currently, conventional physical therapy is complemented by additional physical interventions with recreational components, improving different motor conditions in people with PD. This review aims to evaluate the effectiveness of additional physical interventions to conventional physical therapy in Parkinson’s disease. A systematic review and meta-analysis of randomized controlled trials were performed. The literature search was conducted in PubMed, Physiotherapy Evidence Database (PEDro), Scopus, SciELO and Web of Science. The PEDro scale was used to evaluate the methodological quality of the studies. A total of 11 randomized controlled trials were included in this review. Five of them contributed information to the meta-analysis. The statistical analysis showed favorable results for dance-based therapy in motor balance: (Timed Up and Go: standardized mean difference (SMD) = −1.16; 95% Confidence Interval (CI):(−2.30 to −0.03); Berg Balance Scale: SMD = 4.05; 95%CI:(1.34 to 6.75)). Aquatic interventions showed favorable results in balance confidence (Activities-Specific Balance Confidence: SMD=10.10; 95%CI:(2.27 to 17.93)). The results obtained in this review highlight the potential benefit of dance-based therapy in functional balance for people with Parkinson’s disease, recommending its incorporation in clinical practice. Nonetheless, many aspects require clarification through further research and high-quality studies on this subject.

scholarly journals Aerobic Exercise for Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e100503 ◽  
Author(s):  
Hai-Feng Shu ◽  
Tao Yang ◽  
Si-Xun Yu ◽  
Hai-Dong Huang ◽  
Ling-Li Jiang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Aerobic Exercise ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals Lee Silverman Voice Treatment to Improve Speech in Parkinson’s Disease: A Systemic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Tingting Pu ◽  
Min Huang ◽  
Xiangyu Kong ◽  
Meng Wang ◽  
Xiangling Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Systemic Review ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Lee Silverman Voice Treatment ◽  
Randomized Controlled ◽  
Voice Treatment

Background. Speech changes occur in the early stages of Parkinson’s disease (PD) and cause communication difficulties, leading to social isolation. Lee Silverman voice treatment (LSVT) is a speech therapy approach designed to improve patients’ language and voice capabilities. Objective. The effectiveness of the LSVT was compared with that of other speech interventions or no treatment to evaluate PD patients with dysarthria. Design. Systematic review with meta-analysis of randomized trials. Data Sources: PubMed, Embase, Cochrane Library, CNKI, and SinoMed library were searched from inception to December 2021 related to PD and LSVT. Method. Abstracts were screened and reviewed against the eligibility criteria (intervention group participants were PD assessed based on LSVT (LSVT Loud) and randomized control). Result. Ten randomized controlled trials were identified on speech symptoms in patients with PD. Compared with the respiratory therapy (RET) exercise, or no training group, a significant improvement was detected in the sound press level (SPL) after immediate treatment during the reading of vowel and rainbow passages and an increase in semitone standard deviation (STSD). Furthermore, the LSVT training significantly increased the participants’ scores on unified Parkinson’s disease rating scale (UPDRS-III) and speech intelligibility. Conclusion. This meta-analysis demonstrated the efficacy of LSVT in increasing vocal loudness and functional communication among individuals with PD. However, most studies included participants with mild-moderate PD. Thus, additional randomized controlled trials (RCTs) with large sample sizes are needed to validate the efficacy of LSVT in patients with different progressions of PD, including severe PD.

Scalp acupuncture for Parkinson’s disease: A systematic review of randomized controlled trials

2013 ◽  
Vol 19 (4) ◽  
pp. 297-306 ◽  
Author(s):  
Hun-Soo Lee ◽  
Hye-Lim Park ◽  
Seung-Jin Lee ◽  
Byung-Cheul Shin ◽  
Jun-Yong Choi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Controlled Trials ◽  
Scalp Acupuncture ◽  
Controlled Trials ◽  
Randomized Controlled
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