scholarly journals Effects of Aerobic Exercises on Patients With Coronary Artery Disease

2020 ◽  
Vol 12 (1) ◽  
pp. 167-178
Author(s):  
Farhad Rahmani-Nia ◽  
◽  
Arash Layegh ◽  
Naser Aslanabadi ◽  
◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lipid Profile ◽  
Repeated Measures ◽  
Aerobic Training ◽  
Beta Blockers ◽  
Positive Effects ◽  
Cholesterol Levels ◽  
Artery Disease ◽  
Adrenergic Beta Antagonists

Introduction: Prescribing the Adrenergic beta-Antagonists is very common in treating cardiovascular diseases. The aim of this study was to compare the effects of aerobic training in patients with coronary artery disease, prescribed two different types of beta-blockers (selective and non- selective) on the patient's lipid profile (Lipoproteins) and FBS (Blood Glucose). Materials and Methods: Sixty patients with coronary artery disease, aged 45-65 years, were compared in two groups of selective (n=36) and non-selective (n=24) users of beta-blockers. The training program consisted of 8 weeks of aerobic exercise on the treadmill (3 sessions per week, about 50 minutes per session, with an intensity of 40% to 60% of the heart rate reserve). Each study patient’s lipid profile and FBS level were obtained before the onset of the study and after the end of the intervention. The collected data were analyzed using repeated-measures Analysis of Variance (ANOVA). Results: In the selective group, lipid profile and FBS did not significantly change. In the non-selective group, FBS and triglyceride levels were significantly reduced after the intervention; however, HDL, LDL, and total cholesterol levels were not significantly changed (P>0.05). Conclusion: The results of this study showed that aerobic training in patients with CAD who used non-selective beta-blockers has more positive effects.

P6168Low PCSK9 plasma level is an independent predictor of coronary atherosclerotic burden in patients with stable coronary artery disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Caselli ◽  
R Ragusa ◽  
S Del Turco ◽  
M De Graaf ◽  
G Basta ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lipid Profile ◽  
Risk Score ◽  
Independent Predictor ◽  
Hdl Cholesterol ◽  
Atherosclerotic Burden ◽  
Cholesterol Levels ◽  
Artery Disease ◽  
Stable Cad

Abstract Background Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of LDL cholesterol levels and has emerged as a new therapeutic target in coronary artery disease (CAD). Plasma PCSK9 levels have also been related to other components of the lipid profile associated with atherosclerotic risk. Purpose Aim of the present study was to evaluate the relationship of plasma PCSK9 levels with lipid profile and measures of coronary atherosclerotic burden and risk in patients with stable CAD enrolled in the European EValuation of INtegrated Cardiac Imaging (EVINCI) study. Methods PCSK9 was measured in 412 patients (60.3±8.6 years, 256 males) with symptoms of stable CAD fully characterized by clinical risk factors, bio-humoral profiles, and treatment. All patients underwent coronary computed tomography (CT) angiography to assess the presence and characteristics of coronary atherosclerosis. We calculated an individual CT risk score, expressing the coronary atherosclerotic burden, combining extent, severity, composition, and location of plaques. Results Patients were divided in groups according to PCSK9 quartiles: I (<136 ng/mL), II-III (136–266 ng/mL), and IV quartile (>266 ng/mL). LDL and HDL-cholesterol levels were significantly lower while total/HDL-cholesterol ratio was significantly higher in patients in the quartile I than in those in quartile IV (Figure A). CT angiography documented normal vessels in 30 and obstructive CAD in 35% of cases. Compared with patients with the highest levels (quartile IV), patients with the lowest PCSK9 levels (quartile I) had a higher CT risk score, a higher number of mixed plaque and higher hs-cTnI plasma levels (Figure B). PCSK9 itself was not associated with obstructive CAD. At multivariable analysis including clinical variables, medications and lipid variables PCSK9 was an independent predictor of the CT risk score (Coefficient - 0.129 (SE 0.03), p<0.0001), together with age, male gender and statin treatment. Figure 1 Conclusion PCSK9 levels are independently and inversely associated with the coronary atherosclerotic burden in patients with stable CAD. Acknowledgement/Funding AMGEN grant, EU FP7-CP-FP506 2007 project (grant agreement no. 222915)

Serum Interleukin-6 and Lipid Atherogenic Index Risk Ratios as Interpreters of Cardiac Disease in Obese and Non Obese Male Patients of Coronary Artery Disease

2021 ◽  
Vol 15 (6) ◽  
pp. 1203-1205
Author(s):  
S. Naz ◽  
M. Raza ◽  
A. Akbar ◽  
A. N. Zaidi ◽  
S. Khaliq ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lipid Profile ◽  
Interleukin 6 ◽  
Significant Positive Correlation ◽  
Atherogenic Index ◽  
Positive Correlation ◽  
Male Patients ◽  
Artery Disease ◽  
Obese Male

Aim: To evaluate serum Interleukin-6, and lipids as predictors of cardiovascular diseases (CVD) in obese and non obese male patients of coronary artery disease (CAD). Methodology: It was cross-sectional comparative study. Serum Interleukin-6 and lipid profile was determined in non diabetic, non smoker and non hypertensive age matched obese and non obese male patients of CAD and healthy subjects. Sixty male subjects were divided equally into groups. Group 1, healthy controls (n=20), group 2, non obese male patients with CAD (n=20) and group 3 included Obese male patients with CAD (n=20). The serum was assayed for lipid profile and interleukin-6 . Results: Age matched healthy and patients were non diabetics, non hypertensive and non smoker with altered lipid profile in obese and non obese male patients with coronary artery disease. Patients have high serum cholesterol, low density cholesterol(LDL-C), Triglyceride(TG,) very low density lipoprotein(VLDL) and interleukin-6. The High density lipoprotein was lowered in both obese and non obese male patients with CAD. Significant positive correlation was observed in CAD group of IL-6 with TC (rho= 0.405, p= 0.009*) , with TG (rho= 0.639, p= 0.000*) ,with LDL (rho= 0.398, p= 0.002*), with VLDL (rho= 0.315, p= 0.014*). Significant negative correlation was observed in CAD group of IL-6 with HDL (rho= -0.565, p= 0.000*) Significant positive correlation was observed in CAD group of IL-6 .Significant positive correlation of IL-6 was observed with AI (rho= 0.602, p= 0.000*). Conclusion: Dyslipidemia, Raised interleukin-6 and strong positive correlation of Atherogenic index with IL-6 are independent risk factors for CVD; using Atherogenic risk ratios as a screening tool for the estimation of CVD risk is useful in patients with CAD. Keywords: Lipid profile, serum interleukin-6,Atherogenic index,coronary artery disease.

scholarly journals Serum Copper with Coronary Artery Disease in Male and its Relation with Lipid Profile

1970 ◽  
pp. 7-9
Author(s):  
Sifat Jubaira ◽  
Forhadul Haque Mollah ◽  
Tahrim Mehdi ◽  
M Iqbal Arslan
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Artery Disease

The study was designed to explore serum copper as a risk factor for coronary artery disease (CAD). In this case-control study 30 healthy controls and 60 diagnosed cases of acute myocardial infarction (AMI) were enrolled. Serum copper concentration and serum lipid profile were measured in all study subjects. Serum copper level was significantly higher in AMI as compared to controls. The concentrations of serum TC, TG, LDL-C level were found to be significantly higher in cases as compared to controls. The concentration serum HDL-C was found to be significantly lower in cases as compared to controls. CAD leads to raised serum copper level and it has positive correlation with TC, TG and LDL-C but negative correlation with HDL-C in males.Keywords: Coronary artery disease; serum copper; acute myocardial infarction; total cholesterol; triglyceride; low density lipoprotein cholesterol. DOI: 10.3329/bjpp.v24i1.5730Bangladesh J Physiol Pharmacol 2008; 24(1&2) : 7-9

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