scholarly journals Risk Factors Associated With Renal Involvement in Childhood Henoch-schonlein Purpura

2021 ◽  
Vol 9 (1) ◽  
pp. 53-60
Author(s):  
Maryam Abdollahi ◽  
◽  
Vadood Javadi ◽  
Reza Shiari ◽  
Khosro Rahmani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Cell ◽  
Renal Involvement ◽  
Significant Risk ◽  
Joint Involvement ◽  
Henoch Schonlein Purpura ◽  
Distribution Width ◽  
Factors Associated ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Context: Henoch-Schonlein purpura (HSP) is a significant cause of chronic renal disease in children. This review determines some risk factors associated with renal involvement in childhood HSP. Evidence Acquisition: Electronic databases, including Google Scholar, PubMed, and Scopus were searched using the following keywords: “children”, “Henoch-Schonlein”, “risk factor”, “renal involvement”, and “IgA vasculitis”. This review was designed to identify the relevant electronic studies published in the English language from December 1998 to August 2018. Results: This review revealed that clinically older age at presentation, persistent rash, atypical rash, rash on unusual location, and gastrointestinal bleeding were significant risk factors for renal involvement. In contrast, joint involvement was not associated with renal involvement. Among biochemical markers, high red blood cell distribution width is a risk marker of renal involvement in HSP. In contrast, peripheral blood immunoglobulin A, antinuclear antibody, anti-streptolysin O titer, erythrocyte sedimentation rate, and C-reactive protein were not associated with renal involvement. In several studies, leukocytosis, thrombocytosis, or thrombocytopenia have been mentioned as predictors for renal involvement. Still, other studies showed the white blood cell count or platelet count are not risk factors. The effect of corticosteroids as a predictive factor of renal involvement in HSP is challenging and controversial. Furthermore, their impact was dose-dependent. Conclusions: Demographic factors, clinical features, and some abnormal laboratory findings are significant predictive factors for renal involvement in HSP.

scholarly journals Risk Factors Associated with Renal Involvement in Childhood Henoch-Schönlein Purpura: A Meta-Analysis

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0167346 ◽  
Author(s):  
Han Chan ◽  
Yan-Ling Tang ◽  
Xiao-Hang Lv ◽  
Gao-Fu Zhang ◽  
Mo Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Meta Analysis ◽  
Renal Involvement ◽  
Henoch Schonlein Purpura ◽  
Factors Associated ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals Risk factors for renal involvement and severe kidney disease in 2731 Chinese children with Henoch–Schönlein purpura

Medicine ◽  
2018 ◽  
Vol 97 (38) ◽  
pp. e12520 ◽  
Author(s):  
Ke Wang ◽  
Xiaomei Sun ◽  
Yang Cao ◽  
Liang Dai ◽  
Feiyang Sun ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Disease ◽  
Renal Involvement ◽  
Chinese Children ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Clinical profile and outcome of Henoch Schonlein purpura in a tertiary care hospital in South India

2017 ◽  
Vol 4 (3) ◽  
pp. 822 ◽  
Author(s):  
Shanavas Abbas ◽  
Geetha S. ◽  
Deepthi R.V. ◽  
Jubin Kamar ◽  
Susan Uthup
Keyword(s):  
Clinical Features ◽  
Renal Involvement ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Treatment Modalities ◽  
Joint Involvement ◽  
Care Hospital ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Background: Henoch Schonlein purpura (HSP) is the most common systemic vasculitis in children. It is an immunoglobulin A (IgA) mediated systemic small-vessel vasculitis, with IgA deposition in vessel walls leading to symptoms involving the skin, joints, intestines, and kidneys. The objective of present study was to identify and describe the clinical profile, pattern of joint involvement, histopathological features, treatment modalities and complications of Henoch Schonlein purpura.Methods: 52 children less than 12 years diagnosed to have Henoch Schonlein Purpura according to the European League against Rheumatism criteria were included in the study. All patients were subjected to detailed history taking and thorough examination. The clinical features, investigations, management and complications of the disease were studied. Descriptive statistics was used to analyse the results.Results: The common clinical features were palpable purpura (100%) followed by arthritis (66%) and abdominal pain (50%). Renal manifestations were in the form of hematuria in 12% of the patients. Skin biopsy was done in 25 patients of which 19 had findings suggestive of Henoch Schonlein purpura. Steroids were used in 42% of patients. The severity of illness was associated with lower mean age, arthritis, leg edema and stool occult blood.Conclusions: The clinical features of Henoch Schonlein purpura in the population were different from the previously published studies. Renal involvement was less common. The short-term outcome of the patients were satisfactory. 

scholarly journals Risk factors associated with renal crescentic formation in pediatric Henoch–Schönlein purpura nephritis: a retrospective cohort study

2020 ◽  
Author(s):  
Yong-rui Song ◽  
Wan-liang Guo ◽  
Mao Sheng ◽  
Qiang Lin ◽  
Xue-ming Zhu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Renal Involvement ◽  
Henoch Schonlein Purpura ◽  
Goodness Of Fit Test ◽  
Crescent Formation ◽  
Wbc Count ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
Purpura Nephritis

Abstract Background: The long-term prognosis of Henoch-Schönlein purpura (HSP) depends on the severity of renal involvement, and crescent formation is considered an important risk factor for poor prognosis of Henoch-Schönlein purpura nephritis (HSPN). The objective of this study was to evaluate factors affecting crescent formation in children with HSPN.Methods: Demographic factors, clinical characteristics, and laboratory data of children with HSPN with or without crescents were retrospectively analyzed. Univariate and multivariate logistic regression analyses were used to determine the risk factors of crescent formation in HSPN.Results: A total of 191 children with HSPN were enrolled in the study. There were 107 (56%) males and 84 (44%) females, with a median age of 7 years (range: 2 years–15 years). International Study of Kidney Disease in Children (ISKDC) grading was used to divide subjects into two groups: those without glomerular crescent formation (ISKDC grades I–II, n = 146 cases) and those with glomerular crescent formation (ISKDC grades III–V, n = 45 cases). Logistic regression analysis showed that higher urinary white blood cell (WBC) count (OR = 3.300; 95% CI, 1.119–9.739; P = 0.0306) and higher urinary microalbumin/creatinine ratio (ACR) (OR = 25.053; 95% CI, 1.354–463.708; P = 0.0305) were independent risk factors for the formation of crescents in HSPN. The area under the receiver operating characteristic curve of urinary WBC and ACR were 0.753 and 0.698 respectively, with the Hosmer and Lemeshow goodness-of-fit test (P = 0.0669, P > 0.05).Conclusion: These results suggest that higher urinary WBC count and ACR should be strictly monitored for children with HSPN. Adequate clinical intervention for these risk factors may limit or prevent renal crescent formation.

Risk factors of renal involvement and significant proteinuria in Henoch-Schönlein purpura

2002 ◽  
Vol 161 (4) ◽  
pp. 196-201 ◽  
Author(s):  
Hitomi Sano ◽  
Michiko Izumida ◽  
Hiroshi Shimizu ◽  
Yunosuke Ogawa
Keyword(s):  
Risk Factors ◽  
Renal Involvement ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals Risk factors associated with renal crescentic formation in pediatric Henoch–Schönlein purpura nephritis: a retrospective cohort study

2020 ◽  
Author(s):  
Yong-rui Song ◽  
Wan-liang Guo ◽  
Mao Sheng ◽  
Qiang Lin ◽  
Xue-ming Zhu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Renal Involvement ◽  
Henoch Schonlein Purpura ◽  
Goodness Of Fit Test ◽  
Crescent Formation ◽  
Wbc Count ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
Purpura Nephritis

Abstract Background: The long-term prognosis of Henoch-Schönlein purpura (HSP) depends on the severity of renal involvement, and crescent formation is considered an important risk factor for poor prognosis of Henoch-Schönlein purpura nephritis (HSPN). The objective of this study was to evaluate factors affecting crescent formation in children with HSPN.Methods: Demographic factors, clinical characteristics, and laboratory data of children with HSPN with or without crescents were retrospectively analyzed. Univariate and multivariate logistic regression analyses were used to determine the risk factors of crescent formation in HSPN.Results: A total of 191 children with HSPN were enrolled in the study. There were 107 (56%) males and 84 (44%) females, with a median age of 7 years (range: 2 years–15 years). International Study of Kidney Disease in Children (ISKDC) grading was used to divide subjects into two groups: those without glomerular crescent formation (ISKDC grades I–II, n = 146 cases) and those with glomerular crescent formation (ISKDC grades III–V, n = 45 cases). Logistic regression analysis showed that higher urinary white blood cell (WBC) count (OR = 3.300; 95% CI, 1.119–9.739; P = 0.0306) and higher urinary microalbumin/creatinine ratio (ACR) (OR = 25.053; 95% CI, 1.354–463.708; P = 0.0305) were independent risk factors for the formation of crescents in HSPN. The area under the receiver operating characteristic curve of urinary WBC and ACR were 0.753 and 0.698 respectively, with the Hosmer and Lemeshow goodness-of-fit test (P = 0.0669, P > 0.05).Conclusion: These results suggest that higher urinary WBC count and ACR should be strictly monitored for children with HSPN. Adequate clinical intervention for these risk factors may limit or prevent renal crescent formation.

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