PERUBAHAN MORFOLOGI KATUP MITRAL PADA  DEMAM REMATIK AKUT DAN PENYAKIT JANTUNG REMATIK

<p><em>Rheumatic fever and rheumatic heart disease remains a significant cause of cardiovascular disease in the world, especially in industrial countries and developing countries. Rheumatic heart disease is the most serious complication of rheumatic fever which is characterized by the occurrence of heart valve defects are most of the mitral valve, aortic and tricuspid followed. Valvulitis or inflammatory process in the tissue of the mitral valve causing edema of the valve leaflets and chordae tendineae, causing disruption valve closure is causing mitral regurgitation. Eventually fibrosis and calcification of the valve that causes stiffness and the valve leaflets into mitral valve stenosis. The earliest possible introduction of cardiac involvement in rheumatic heart disease is an important part in the prevention of further heart damage. </em></p>

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Patterns of Valvular Involvement in Rheumatic Heart Disease patients taking Benzathine Penicillin at Shahid Gangalal National Heart Centre, Kathmandu, Nepal

Nepalese Heart Journal ◽

10.3126/njh.v13i2.15560 ◽

2016 ◽

Vol 13 (2) ◽

pp. 25-27 ◽

Cited By ~ 3

Author(s):

Rabi Malla ◽

Suman Thapaliya ◽

Prakash Gurung ◽

Amit Bogati ◽

Sunita Khadka ◽

...

Keyword(s):

Heart Disease ◽

Mitral Valve ◽

Rheumatic Fever ◽

Rheumatic Heart Disease ◽

Public Health Problem ◽

Autoimmune Response ◽

Benzathine Penicillin ◽

Important Public Health Problem ◽

Susceptible Host ◽

Rheumatic Heart

Background and Aims: Acute rheumatic fever and rheumatic heart disease constitute an important public health problem in the developing countries. The disease results from an abnormal autoimmune response to a group A streptococcal infection in a susceptible host. We aim to describe the pattern of valvular involvement in patients taking Injection Benzathine Penicillin.Methods: All the patients, who were taking injection Benzathine penicillin during 15th April to 14th July, 2013 at our Centre, were included in this study. Demographic features like age, sex, echocardiographic diagnosis along with any adverse effects of Benzathine penicillin were collected.Results: A total of 661 patients were included in our study, out of which female predominated in numbers. Rheumatic heart disease rather than rheumatic fever was the cause for Penicillin injection. Mitral valve was the most common valve involved and it was more common in female.Pure mitral stenosis was the most common valvular involvement. Forty two percent patients underwent intervention; among them Percutaneous transluminal mitral commisuorotomy was the most common. There was no adverse event during the study time following penicillin injection.Conclusions: Women are more commonly affected than male. Mitral valve is the most common valve involved. Nepalese Heart Journal 2016; 13(2): 25-27

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Very early complication of rheumatic heart disease (valvuloplasty for severe mitral valve stenosis for 6 year old male patient)

Journal of the Saudi Heart Association ◽

10.1016/j.jsha.2013.03.141 ◽

2013 ◽

Vol 25 (2) ◽

pp. 156-157

Author(s):

A. Annonu ◽

Nawar Ali Alwather ◽

Ahmed Al-Motarreb

Keyword(s):

Heart Disease ◽

Mitral Valve ◽

Rheumatic Heart Disease ◽

Male Patient ◽

Mitral Valve Stenosis ◽

Early Complication ◽

Rheumatic Heart

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P1363 Risk factors of severe tricuspid regurgitation after left-sided valve surgery

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.798 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

R Horita ◽

K Mahara ◽

Y Izumi ◽

M Terada ◽

K Kishiki ◽

...

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Mitral Valve ◽

Rheumatic Heart Disease ◽

Tricuspid Regurgitation ◽

Valve Surgery ◽

Mitral Valve Stenosis ◽

Tricuspid Valve Repair ◽

Icd Implantation ◽

Rheumatic Heart

Abstract Background Tricuspid regurgitation (TR) sometimes deteriorate late after left-sided valve surgery. The recent guidelines recommend tricuspid valve repair at the same time as the left-sided valve surgery. However, little is known about the pathophysiology that leads to severe TR after left-sided valve surgery. Purpose To clarify the risk factors of the patients with severe TR after left-sided valve surgery. Methods We retrospectively investigated consecutive 526 patients diagnosed as severe TR from January 2004 to December 2018 at our hospital. Clinical background, echocardiographic parameters were evaluated. Demographic information and clinical data (including age, electrocardiograms, type of left-sided valve surgery, underlying valve diseases and history of pacemaker or ICD implantation) were obtained by chart review. Results Of the 526 patients with severe TR, 107 patients were after a left-sided valve surgery. Patients developed severe TR at a mean of 14.8 ± 8 years after surgery.The surgical indications were as follows: mitral valve stenosis (74 patients, 69%), mitral valve regurgitation (43 patients, 40%), aortic valve stenosis (37 patients, 35%) and aortic regurgitation (28 patients, 26%), respectively. The mean age at diagnosis of severe TR was 74 ± 10 years and 75 were female (70%). Among those patients, 32 patients (30%) had a tricuspid annuloplasty (TAP) with the first left-sided valve surgery. Ninety-five patients (88%) had atrial fibrillation (AF), 75 patients (70%) were diagnosed as rheumatic heart disease, 64 patients (60%) had pulmonary artery hypertension (PH) and 28 patients (26%) had a permanent pacemaker or ICD implantation. There were only 12 patients who had severe TR without AF. Eight of 12 patients without AF had PH, and permanent pacemakers were implanted in remaining 4 patients. Conclusions Almost all patients with severe TR after left-sided valve surgery present with AF and prevalence of rheumatic heart disease were about 70 percent. These two factors may be one of the important risk factors for severe TR after left-sided valve surgery.

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Clinical study of appropriate length artificial chordae tendineae implantation in Mitral Valve Replacement for rheumatic heart disease

10.22541/au.160067357.76919539 ◽

2020 ◽

Author(s):

Zulei Zhang ◽

Fajia Hu ◽

Wei Yang ◽

Yi Gong ◽

Chao Lu ◽

...

Keyword(s):

Heart Disease ◽

Clinical Study ◽

Mitral Valve ◽

Rheumatic Heart Disease ◽

Valve Replacement ◽

Mitral Valve Replacement ◽

Chordae Tendineae ◽

Artificial Chordae ◽

Rheumatic Heart

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Aortic and Mitral Valve Stenosis with Regurgitation: Not Due to Rheumatic Heart Disease

Echocardiography ◽

10.1111/j.1540-8175.2010.01253.x ◽

2010 ◽

Vol 28 (2) ◽

pp. E24-E27 ◽

Cited By ~ 4

Author(s):

Christopher J. Talluto ◽

Norman H. Silverman

Keyword(s):

Heart Disease ◽

Mitral Valve ◽

Rheumatic Heart Disease ◽

Mitral Valve Stenosis ◽

Rheumatic Heart

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Randomised controlled trial into the role of ramipril in fibrosis reduction in rheumatic heart disease: the RamiRHeD trial protocol

BMJ Open ◽

10.1136/bmjopen-2020-048016 ◽

2021 ◽

Vol 11 (9) ◽

pp. e048016

Author(s):

Ade Meidian Ambari ◽

Budhi Setianto ◽

Anwar Santoso ◽

Basuni Radi ◽

Bambang Dwiputra ◽

...

Keyword(s):

Heart Disease ◽

Mitral Valve ◽

Chronic Inflammation ◽

Rheumatic Heart Disease ◽

Transforming Growth Factor ◽

Controlled Trial ◽

Mitral Valve Stenosis ◽

Valve Tissue ◽

Cardiovascular Morbidity And Mortality ◽

Rheumatic Heart

IntroductionRheumatic heart disease (RHD) is a major burden in developing countries and accounts for 80% of all people living with the disease, where it causes most cardiovascular morbidity and mortality in children and young adults. Chronic inflammation and fibrosis of heart valve tissue due to chronic inflammation in RHD will cause calcification and thickening of the impacted heart valves, especially the mitral valve. This fibrogenesis is enhanced by the production of angiotensin II by increased transforming growth factor β expression and later by the binding of interleukin-33, which is known to have antihypertrophic and antifibrotic effects, to soluble sST2. sST2 binding to this non-natural ligand worsens fibrosis. Therefore, we hypothesise that ACE inhibitors (ACEIs) would improve rheumatic mitral valve stenosis.Methods and analysisThis is a single-centre, double-blind, placebo-controlled, randomised clinical trial with a pre–post test design. Patients with rheumatic mitral stenosis and valve dysfunction will be planned for cardiac valve replacement operation and will be given ramipril 5 mg or placebo for a minimum of 12 weeks before the surgery. The expression of ST2 in the mitral valve is considered to be representative of cardiac fibrosis. Mitral valve tissue will be stained by immunohistochemistry to ST2. Plasma ST2 will be measured by ELISA. This study is conducted in the Department of Cardiology and Vascular Medicine, Universitas Indonesia, National Cardiac Center Harapan Kita Hospital, Jakarta, Indonesia, starting on 27 June 2019.Ethics and disseminationThe performance and dissemination of this study were approved by the ethics committee of National Cardiovascular Center Harapan Kita with ethical code LB.02.01/VII/286/KEP.009/2018.Trial registration numberNCT03991910.

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Pattern of rheumatic heart disease in Western Rajasthan- an echocardiographic study: a single centre experience

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20193940 ◽

2019 ◽

Vol 7 (9) ◽

pp. 3522

Author(s):

Rohit Mathur ◽

Palsingh Yadav ◽

Sanjeev Sanghvi ◽

Anil Baroopal ◽

Swati Mahajan

Keyword(s):

Heart Disease ◽

Mitral Valve ◽

Rheumatic Fever ◽

Rheumatic Heart Disease ◽

Heart Valve Disease ◽

Single Centre ◽

Medical College ◽

Echocardiographic Study ◽

Single Centre Experience ◽

Rheumatic Heart

Background: Rheumatic heart disease (RHD) is a common form of heart valve disease associated with episodes of rheumatic fever. Despite the developments achieved in the field of cardiology, the consequences of acute rheumatic fever remain significantly high in developing countries like India. Objectives of current study aims to evaluate the pattern of valvular involvement in patients of RHD in Western Rajasthan assessed by echocardiography.Methods: This is an observational study conducted at the department of Cardiology, Dr. S. N. Medical College, Jodhpur, India between September 2015 and February 2019. The study includes analysis of echocardiograms of RHD patients performed during this period.Results: Total 502 echocardiograms of RHD patients between 4 and 75 years of age with mean age of 35.6 ±11.6 years in which the most common age group was 21-40 years. There were 191 (38.04%) males, and 311 (61.95%) females. Mitral valve was most commonly involved in which mitral stenosis (MS) was seen in 345 (68.72%) and mitral regurgitation (MR) was seen in 350(69.72%) patients. Aortic stenosis (AS) was seen in 61 (12.15%) and aortic regurgitation (AR) was found in 224 (44.62%) cases. Organic tricuspid valve (TV) disease was seen in 18 (3.58%). In combined valvular involvement MS+MR was seen in 234 (46.61%) cases; followed by MR+AR in 171 (34.06%); MS+AR in 161 (32.07%); AS+AR in 62 (12.35%); MR+AS in 46 (9.16%) and MS+AS in 42 (8.36%) subjects.Conclusion: The echocardiographic pattern of RHD patients of Western Rajasthan shows a predominant involvement of mitral valve, followed by aortic and tricuspid valves. Further amongst multi-valvular involvement the sequence was predominantly MS+MR followed by MR+AR, MS+AR, AS+AR, MR+AS, and MS+AS.

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