Novel effects of Prefoldin Pathway on Intestinal Homeostasis via Dietary Restriction in Drosophila melanogaster

2016 ◽  
Author(s):  
Jesse Simmons
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Intestinal Homeostasis

scholarly journals Testing evolutionary explanations for the lifespan benefit of dietary restriction in fruit flies ( Drosophila melanogaster )

Evolution ◽  
2020 ◽  
Author(s):  
Eevi Savola ◽  
Clara Montgomery ◽  
Fergal M. Waldron ◽  
Katy M. Monteith ◽  
Pedro Vale ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Fruit Flies ◽  
Evolutionary Explanations

scholarly journals Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74681 ◽  
Author(s):  
Athanasios Metaxakis ◽  
Linda Partridge
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction

scholarly journals Monoassociation withLactobacillus plantarumDisrupts Intestinal Homeostasis in AdultDrosophila melanogaster

mBio ◽  
2018 ◽  
Vol 9 (4) ◽  
Author(s):  
David Fast ◽  
Aashna Duggal ◽  
Edan Foley
Keyword(s):  
Drosophila Melanogaster ◽  
Stem Cell ◽  
Simple Model ◽  
Life Span ◽  
Lactobacillus Plantarum ◽  
Adult Longevity ◽  
Intestinal Homeostasis ◽  
Content Type ◽  
Cell Divisions ◽  
Stem Cell Divisions

ABSTRACTAdultDrosophila melanogasterraised in the absence of symbiotic bacteria have fewer intestinal stem cell divisions and a longer life span than their conventionally reared counterparts. However, we do not know if increased stem cell divisions are essential for symbiont-dependent regulation of longevity. To determine if individual symbionts cause aging-dependent death inDrosophila, we examined the impacts of common symbionts on host longevity. We found that monoassociation of adultDrosophilawithLactobacillus plantarum, a widely reported fly symbiont and member of the probioticLactobacillusgenus, curtails adult longevity relative to germfree counterparts. The effects ofLactobacillus plantarumon life span were independent of intestinal aging. Instead, we found that association withLactobacillus plantarumcauses an extensive intestinal pathology within the host, characterized by loss of stem cells, impaired epithelial renewal, and a gradual erosion of epithelial ultrastructure. Our study uncovers an unknown aspect ofLactobacillus plantarum-Drosophilainteractions and establishes a simple model to characterize symbiont-dependent disruption of intestinal homeostasis.IMPORTANCEUnder homeostatic conditions, gut bacteria provide molecular signals that support the organization and function of the host intestine. Sudden shifts in the composition or distribution of gut bacterial communities impact host receipt of bacterial cues and disrupt tightly regulated homeostatic networks. We used theDrosophila melanogastermodel to determine the effects of prominent fly symbionts on host longevity and intestinal homeostasis. We found that monoassociation withLactobacillus plantarumleads to a loss of intestinal progenitor cells, impaired epithelial renewal, and disruption of gut architecture as flies age. These observations uncover a novel phenotype caused by monoassociation of a germfree host with a common symbiont and establish a simple model to characterize symbiont-dependent loss of intestinal homeostasis.

Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity

2004 ◽  
Vol 39 (7) ◽  
pp. 1011-1019 ◽  
Author(s):  
William Mair ◽  
Carla M Sgrò ◽  
Alice P Johnson ◽  
Tracey Chapman ◽  
Linda Partridge
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Lifespan Extension ◽  
Ovarian Activity

scholarly journals Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster

2012 ◽  
Vol 16 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Subhash D. Katewa ◽  
Fabio Demontis ◽  
Marysia Kolipinski ◽  
Alan Hubbard ◽  
Matthew S. Gill ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Dietary Restriction ◽  
Acid Metabolism ◽  
Critical Role

Dietary Restriction and Aging in Drosophila Melanogaster

2010 ◽  
pp. 79-95
Author(s):  
Luc Poirier ◽  
Rafael de Cabo ◽  
Sige Zou
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction

scholarly journals Optimization of Dietary Restriction Protocols in Drosophila

2007 ◽  
Vol 62 (10) ◽  
pp. 1071-1081 ◽  
Author(s):  
Timothy M. Bass ◽  
Richard C. Grandison ◽  
Richard Wong ◽  
Pedro Martinez ◽  
Linda Partridge ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Adverse Effects ◽  
Life Span ◽  
Dietary Restriction ◽  
Food Composition ◽  
Model Organisms ◽  
Nutritional Content ◽  
Evolutionarily Conserved ◽  
Interspecific Comparisons

Abstract Dietary restriction (DR) extends life span in many organisms, through unknown mechanisms that may or may not be evolutionarily conserved. Because different laboratories use different diets and techniques for implementing DR, the outcomes may not be strictly comparable. This complicates intra- and interspecific comparisons of the mechanisms of DR and is therefore central to the use of model organisms to research this topic. Drosophila melanogaster is an important model for the study of DR, but the nutritional content of its diet is typically poorly defined. We have compared fly diets composed of different yeasts for their effect on life span and fecundity. We found that only one diet was appropriate for DR experiments, indicating that much of the published work on fly “DR” may have included adverse effects of food composition. We propose procedures to ensure that diets are suitable for the study of DR in Drosophila.

scholarly journals Effect of a Standardised Dietary Restriction Protocol on Multiple Laboratory Strains of Drosophila melanogaster

PLoS ONE ◽  
2009 ◽  
Vol 4 (1) ◽  
pp. e4067 ◽  
Author(s):  
Richard C. Grandison ◽  
Richard Wong ◽  
Timothy M. Bass ◽  
Linda Partridge ◽  
Matthew D. W. Piper
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction
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