Dietary Restriction and Aging in Drosophila Melanogaster

2010 ◽  
pp. 79-95
Author(s):  
Luc Poirier ◽  
Rafael de Cabo ◽  
Sige Zou
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction

scholarly journals Testing evolutionary explanations for the lifespan benefit of dietary restriction in fruit flies ( Drosophila melanogaster )

Evolution ◽  
2020 ◽  
Author(s):  
Eevi Savola ◽  
Clara Montgomery ◽  
Fergal M. Waldron ◽  
Katy M. Monteith ◽  
Pedro Vale ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Fruit Flies ◽  
Evolutionary Explanations

scholarly journals Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74681 ◽  
Author(s):  
Athanasios Metaxakis ◽  
Linda Partridge
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction

Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity

2004 ◽  
Vol 39 (7) ◽  
pp. 1011-1019 ◽  
Author(s):  
William Mair ◽  
Carla M Sgrò ◽  
Alice P Johnson ◽  
Tracey Chapman ◽  
Linda Partridge
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Lifespan Extension ◽  
Ovarian Activity

scholarly journals Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster

2012 ◽  
Vol 16 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Subhash D. Katewa ◽  
Fabio Demontis ◽  
Marysia Kolipinski ◽  
Alan Hubbard ◽  
Matthew S. Gill ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Dietary Restriction ◽  
Acid Metabolism ◽  
Critical Role

scholarly journals Optimization of Dietary Restriction Protocols in Drosophila

2007 ◽  
Vol 62 (10) ◽  
pp. 1071-1081 ◽  
Author(s):  
Timothy M. Bass ◽  
Richard C. Grandison ◽  
Richard Wong ◽  
Pedro Martinez ◽  
Linda Partridge ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Adverse Effects ◽  
Life Span ◽  
Dietary Restriction ◽  
Food Composition ◽  
Model Organisms ◽  
Nutritional Content ◽  
Evolutionarily Conserved ◽  
Interspecific Comparisons

Abstract Dietary restriction (DR) extends life span in many organisms, through unknown mechanisms that may or may not be evolutionarily conserved. Because different laboratories use different diets and techniques for implementing DR, the outcomes may not be strictly comparable. This complicates intra- and interspecific comparisons of the mechanisms of DR and is therefore central to the use of model organisms to research this topic. Drosophila melanogaster is an important model for the study of DR, but the nutritional content of its diet is typically poorly defined. We have compared fly diets composed of different yeasts for their effect on life span and fecundity. We found that only one diet was appropriate for DR experiments, indicating that much of the published work on fly “DR” may have included adverse effects of food composition. We propose procedures to ensure that diets are suitable for the study of DR in Drosophila.

scholarly journals Effect of a Standardised Dietary Restriction Protocol on Multiple Laboratory Strains of Drosophila melanogaster

PLoS ONE ◽  
2009 ◽  
Vol 4 (1) ◽  
pp. e4067 ◽  
Author(s):  
Richard C. Grandison ◽  
Richard Wong ◽  
Timothy M. Bass ◽  
Linda Partridge ◽  
Matthew D. W. Piper
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction

scholarly journals Evolution Under Dietary Restriction Decouples Survival From Fecundity in Drosophila melanogaster Females

2018 ◽  
Vol 74 (10) ◽  
pp. 1542-1548 ◽  
Author(s):  
Felix Zajitschek ◽  
Grigorios Georgolopoulos ◽  
Anna Vourlou ◽  
Maja Ericsson ◽  
Susanne R K Zajitschek ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Life History Theory ◽  
Resource Reallocation ◽  
Life Span Extension ◽  
Somatic Maintenance ◽  
Restriction Diet ◽  
Investment In Reproduction ◽  
The Cost ◽  
Full Factorial

Abstract One of the key tenets of life-history theory is that reproduction and survival are linked and that they trade-off with each other. When dietary resources are limited, reduced reproduction with a concomitant increase in survival is commonly observed. It is often hypothesized that this dietary restriction effect results from strategically reduced investment in reproduction in favor of somatic maintenance to survive starvation periods until resources become plentiful again. We used experimental evolution to test this “waiting-for-the-good-times” hypothesis, which predicts that selection under sustained dietary restriction will favor increased investment in reproduction at the cost of survival because “good-times” never come. We assayed fecundity and survival of female Drosophila melanogaster fruit flies that had evolved for 50 generations on three different diets varying in protein content—low (classic dietary restriction diet), standard, and high—in a full-factorial design. High-diet females evolved overall increased fecundity but showed reduced survival on low and standard diets. Low-diet females evolved reduced survival on low diet without corresponding increase in reproduction. In general, there was little correspondence between the evolution of survival and fecundity across all dietary regimes. Our results contradict the hypothesis that resource reallocation between fecundity and somatic maintenance underpins life span extension under dietary restriction.

scholarly journals Evolution under dietary restriction increases male reproductive performance without survival cost

2016 ◽  
Vol 283 (1825) ◽  
pp. 20152726 ◽  
Author(s):  
Felix Zajitschek ◽  
Susanne R. K. Zajitschek ◽  
Cindy Canton ◽  
Grigorios Georgolopoulos ◽  
Urban Friberg ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Reproductive Success ◽  
Dietary Restriction ◽  
Reproductive Performance ◽  
Experimental Evolution ◽  
Nutrient Intake ◽  
Overlapping Generations ◽  
Tree Of Life ◽  
Wide Range ◽  
Reallocation Of Resources

Dietary restriction (DR), a reduction in nutrient intake without malnutrition, is the most reproducible way to extend lifespan in a wide range of organisms across the tree of life, yet the evolutionary underpinnings of the DR effect on lifespan are still widely debated. The leading theory suggests that this effect is adaptive and results from reallocation of resources from reproduction to somatic maintenance, in order to survive periods of famine in nature. However, such response would cease to be adaptive when DR is chronic and animals are selected to allocate more resources to reproduction. Nevertheless, chronic DR can also increase the strength of selection resulting in the evolution of more robust genotypes. We evolved Drosophila melanogaster fruit flies on ‘DR’, ‘standard’ and ‘high’ adult diets in replicate populations with overlapping generations. After approximately 25 generations of experimental evolution, male ‘DR’ flies had higher fitness than males from ‘standard’ and ‘high’ populations. Strikingly, this increase in reproductive success did not come at a cost to survival. Our results suggest that sustained DR selects for more robust male genotypes that are overall better in converting resources into energy, which they allocate mostly to reproduction.

scholarly journals Dietary restriction affects lifespan but not cognitive aging in Drosophila melanogaster

Aging Cell ◽  
2010 ◽  
Vol 9 (3) ◽  
pp. 327-335 ◽  
Author(s):  
Joep M.S. Burger ◽  
Séverine D. Buechel ◽  
Tadeusz J. Kawecki
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Cognitive Aging
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