Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity

2004 ◽  
Vol 39 (7) ◽  
pp. 1011-1019 ◽  
Author(s):  
William Mair ◽  
Carla M Sgrò ◽  
Alice P Johnson ◽  
Tracey Chapman ◽  
Linda Partridge
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Lifespan Extension ◽  
Ovarian Activity

scholarly journals Testing evolutionary explanations for the lifespan benefit of dietary restriction in Drosophila melanogaster

2020 ◽  
Author(s):  
Eevi Savola ◽  
Clara Montgomery ◽  
Fergal M. Waldron ◽  
Katy Monteith ◽  
Pedro Vale ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Side Effect ◽  
Bacterial Pathogen ◽  
Lifespan Extension ◽  
Trade Off ◽  
Scarce Resources ◽  
Evolutionary Hypothesis ◽  
Laboratory Conditions ◽  
Extended Lifespan

ABSTRACTDietary restriction (DR), limiting calories or specific nutrients, extends lifespan across diverse taxa. This lifespan extension has been explained as diet-mediated changes in the trade-off between lifespan and reproduction, with survival favoured with scarce resources. Another evolutionary hypothesis suggests the selective benefit of the response is the maintenance of reproduction. This hypothesis predicts that lifespan extension is a side effect of benign laboratory conditions, where DR individuals are frailer and unable to deal with additional stressors, and thus lifespan extension should disappear under more stressful conditions. We tested this by rearing outbred female Drosophila melanogaster on 10 different protein:carbohydrate diets. Flies were either infected with a bacterial pathogen (Pseudomonas entomophila), injured or unstressed. We monitored lifespan, fecundity and ageing measures. DR extended lifespan and reduced reproduction irrespective of injury and infection. These results do not support lifespan extension under DR being a side effect of benign laboratory conditions.

scholarly journals The relationship between longevity and diet is genotype dependent and sensitive to desiccation in Drosophila melanogaster

2020 ◽  
Vol 223 (23) ◽  
pp. jeb230185
Author(s):  
Andrew W. McCracken ◽  
Eleanor Buckle ◽  
Mirre J. P. Simons
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Variation ◽  
Dietary Restriction ◽  
Water Availability ◽  
Reaction Norms ◽  
Desiccation Stress ◽  
Lifespan Extension ◽  
Ageing Research ◽  
The Relationship ◽  
Water Supplementation

ABSTRACTDietary restriction (DR) is a key focus in ageing research. Specific conditions and genotypes were recently found to negate lifespan extension by DR, questioning its universal relevance. However, the concept of dietary reaction norms explains why the effects of DR might be obscured in some situations. We tested the importance of dietary reaction norms by measuring longevity and fecundity on five diets in five genotypes, with and without water supplementation in female Drosophila melanogaster (N>25,000). We found substantial genetic variation in the response of lifespan to diet. Flies supplemented with water rescued putative desiccation stress on the richest diets, suggesting that water availability can be an experimental confound. Fecundity declined on these richest diets, but was unaffected by water, and this reduction is thus most likely to be caused by nutritional toxicity. Our results demonstrate empirically that a range of diets need to be considered to conclude an absence of the DR longevity effect.

scholarly journals Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster

Aging Cell ◽  
2009 ◽  
Vol 8 (3) ◽  
pp. 331-338 ◽  
Author(s):  
Ursula Edman ◽  
Ana Maria Garcia ◽  
Rita A. Busuttil ◽  
Dylan Sorensen ◽  
Martha Lundell ◽  
...  
Keyword(s):  
Dna Damage ◽  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Lifespan Extension

scholarly journals Testing evolutionary explanations for the lifespan benefit of dietary restriction in fruit flies ( Drosophila melanogaster )

Evolution ◽  
2020 ◽  
Author(s):  
Eevi Savola ◽  
Clara Montgomery ◽  
Fergal M. Waldron ◽  
Katy M. Monteith ◽  
Pedro Vale ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Dietary Restriction ◽  
Fruit Flies ◽  
Evolutionary Explanations

scholarly journals Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

Aging Cell ◽  
2010 ◽  
Vol 10 (1) ◽  
pp. 39-54 ◽  
Author(s):  
Laurent Mouchiroud ◽  
Laurent Molin ◽  
Prasad Kasturi ◽  
Mohamed N. Triba ◽  
Marc Emmanuel Dumas ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Dietary Restriction ◽  
Metabolic Reprogramming ◽  
Lifespan Extension

scholarly journals Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans

2021 ◽  
Vol 288 (1950) ◽  
Author(s):  
Edward R. Ivimey-Cook ◽  
Kris Sales ◽  
Hanne Carlsson ◽  
Simone Immler ◽  
Tracey Chapman ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Dietary Restriction ◽  
Mortality Risk ◽  
Lifespan Extension ◽  
Dietary Interventions ◽  
Negative Effects ◽  
Trade Offs ◽  
Wide Range ◽  
Broad Variety

Dietary restriction (DR) increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here, we investigated the effect of DR by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in Caenorhabditis elegans . We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P 0 ), it has a wide range of both positive and negative effects on their descendants (F 1 –F 3 ). Remarkably, great-grandparental exposure to TF in early life reduces fitness and increases mortality risk of F 3 descendants to such an extent that TF no longer promotes a lifespan extension. These findings reveal that transgenerational trade-offs accompany the instant benefits of DR, underscoring the need to consider fitness of future generations in pursuit of healthy ageing.

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