The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases

2017 ◽  
Author(s):  
Sana Khateeb
Keyword(s):  
Neurodegenerative Diseases ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Activation Pathway ◽  
Glycation End Products ◽  
End Products

scholarly journals In Vitro Methodologies to Study the Role of Advanced Glycation End Products (AGEs) in Neurodegeneration

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 363
Author(s):  
Marialena Chrysanthou ◽  
Ignacio Miro Estruch ◽  
Ivonne M. C. M. Rietjens ◽  
Harry J. Wichers ◽  
Tamara Hoppenbrouwers
Keyword(s):  
Neurodegenerative Diseases ◽  
Advanced Glycation End Products ◽  
In Vitro Models ◽  
Research Field ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Specific Receptors

Advanced glycation end products (AGEs) can be present in food or be endogenously produced in biological systems. Their formation has been associated with chronic neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis. The implication of AGEs in neurodegeneration is related to their ability to bind to AGE-specific receptors and the ability of their precursors to induce the so-called “dicarbonyl stress”, resulting in cross-linking and protein damage. However, the mode of action underlying their role in neurodegeneration remains unclear. While some research has been carried out in observational clinical studies, further in vitro studies may help elucidate these underlying modes of action. This review presents and discusses in vitro methodologies used in research on the potential role of AGEs in neuroinflammation and neurodegeneration. The overview reveals the main concepts linking AGEs to neurodegeneration, the current findings, and the available and advisable in vitro models to study their role. Moreover, the major questions regarding the role of AGEs in neurodegenerative diseases and the challenges and discrepancies in the research field are discussed.

scholarly journals Role of advanced glycation end products in cellular signaling

Redox Biology ◽  
2014 ◽  
Vol 2 ◽  
pp. 411-429 ◽  
Author(s):  
Christiane Ott ◽  
Kathleen Jacobs ◽  
Elisa Haucke ◽  
Anne Navarrete Santos ◽  
Tilman Grune ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Cellular Signaling ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

The role of receptor for advanced glycation end products (RAGE) in neuronal differentiation

2012 ◽  
Vol 90 (6) ◽  
pp. 1136-1147 ◽  
Author(s):  
Joanne Kim ◽  
Carthur K. Wan ◽  
Simon J. O'Carroll ◽  
Shamim B. Shaikh ◽  
Louise F.B. Nicholson
Keyword(s):  
Neuronal Differentiation ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products
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