scholarly journals KORELASI KADAR HEMOGLOBIN DENGAN LAJU FILTRASI GLOMERULUS PADA PASIEN GAGAL GINJAL KRONIK STADIUM 3 DAN 4

2021 ◽  
Vol 7 (3) ◽  
pp. 489-494
Author(s):  
Siska Monika Faridz ◽  
Syuhada Syuhada ◽  
Akhmad Kheru
Keyword(s):  
Renal Failure ◽  
Glomerular Filtration Rate ◽  
Chronic Renal Failure ◽  
Glomerular Filtration ◽  
Kidney Failure ◽  
Filtration Rate ◽  
Pearson Correlation ◽  
Strong Relationship ◽  
Chronic Kidney Failure ◽  
P Value

Background Chronic kidney disease was one of the 18 causes of death in 2010. Anemia is a complication of CKD that often occurs even earlier than other complications. Renal dysfunction results in reduced creatinine filtration ability and an increase in serum creatinine.Purpose of this study was to determine the correlation between hemoglobin levels and glomerular filtration rate in patients with stage 3 and 4 chronic kidney failure at Abdul Moeloek Hospital in Bandar Lampung in 2020.Methods  This type of research is quantitative with retrospective analytical methods. The research was conducted at the Medical Records section of the Abdul Moeloek Hospital Bandar Lampung from December 2020 to completion. The number of samples as many as 36 people using the person correlation statistical test. Result Based on the results of the Pearson correlation analysis between hemoglobin levels and glomerular filtration rate in patients with stage 3 and 4 chronic kidney failure at Abdul Moeloek Hospital, Bandar Lampung, 2020 shows a relationship with r (correlation coefficient) of, 688. This data shows that there is a positive relationship between hemoglobin levels and glomerular filtration rate in patients with stage 3 and 4 chronic renal failure at Abdul Moeloek Hospital, Bandar Lampung in 2020, the relationship is categorized as a strong relationship (0.61-0.80). . The P-value = 0,000 indicates a significant relationship between hemoglobin levels and glomerular filtration rate in patients with stage 3 and 4 chronic renal failure at Abdul Moeloek Hospital Bandar Lampung in 2020. Conclusion There is a correlation between hemoglobin levels and glomerular filtration rate in patients with stage chronic renal failure. 3 and 4 at Abdul Moeloek Hospital in Bandar Lampung in 2020Suggestions for the Community The community is expected to seek information regarding the prevention of kidney failure and then start living a healthy lifestyle to avoid kidney failure. For patients with kidney failure, they should regularly check themselves to the nearest health facility and check creatinine and hemoglobin levels. Keywords: Chronic renal failure, Creatinine, Hemoglobin, Glumerular Filtration Rate ABSTRAK Latar Belakang Penyakit ginjal kronik salah satu penyebab kematian ke-18 pada tahun 2010. Anemia merupakan salah satu komplikasi PGK yang sering terjadi bahkan terjadi lebih awal dari komplikasi lainnya. Disfungsi ginjal mengakibatkan kemampuan filtrasi kreatinin akan berkurang dan akan terjadi peningkatan pada kreatinin serum.Tujuan penelitian ini untuk mengetahui korelasi antara kadar hemoglobin dengan laju filtrasi glomerulus pada pasien gagal ginjal kronik stadium 3 dan 4 di Rumah Sakit Abdul Moeloek Bandar Lampung Tahun 2020.Metode Jenis penelitian ini adalah kuantitatif dengan metode analitik retrospektif. Penelitian dilakukan di bagian Rekam Medik Rumah Sakit Abdul Moeloek Bandar Lampung pada bulan Desember 2020 hingga selesai. jumlah sampel sebanyak 36 orang menggunakan uji statistic korelasi person. Berdasarkan hasil analisi korelasi Pearson antara kadar hemoglobin dengan laju filtrasi glomerulus pada pasien gagal ginjal kronik stadium 3 dan 4 di Rumah Sakit Abdul Moeloek Bandar Lampung Tahun 2020 menunjukan adanya hubungan dengan r (koefisien korelasi) sebesar ,688.Hasil Data ini menunjukan bahwa terdapat hubungan positif antara kadar hemoglobin dengan laju filtrasi glomerulus pada pasien gagal ginjal kronik stadium 3 dan 4 di Rumah Sakit Abdul Moeloek Bandar Lampung Tahun 2020 hubunganya dikategorikan sebagai hubungan yang kuat (strong) (0,61-0,80). Nilai P-value = 0,000 menunjukan hubungan signifikan antara kadar hemoglobin dengan laju filtrasi glomerulus pada pasien gagal ginjal kronik stadium 3 dan 4 di Rumah Sakit Abdul Moeloek Bandar Lampung Tahun 2020.Kesimpulan Terdapat korelasi antara kadar hemoglobin dengan laju filtrasi glomerulus pada pasien gagal ginjal kronik stadium 3 dan 4 di Rumah Sakit Abdul Moeloek Bandar Lampung Tahun 2020.Saran Bagi Masyarakat Masyarakat diharapkan mencari informasi terkait penegahan penyakit gagal ginjal kemudian mulai menjalani gaya hidup sehat agar terhindar dari penyakit gagal ginjal. Bagi penderita gagal ginjal agar rutin memeriksanakn diri ke fasilitas kesehatan terdekat dan memeriksakan kadar kreatinin serta hemoglobin. Kata Kunci : Gagal ginjal kronik, Kreatinin, Hemoglobin, Laju Filtrasi Glumerulus

Effect of Proportional Reduction of Sodium Intake on the Adaptive Increase in Glomerular Filtration Rate/Nephron and Potassium and Phosphate Excretion in Chronic Renal Failure in the Rat

1975 ◽  
Vol 49 (3) ◽  
pp. 193-200 ◽  
Author(s):  
C. H. Espinel
Keyword(s):  
Renal Failure ◽  
Glomerular Filtration Rate ◽  
Chronic Renal Failure ◽  
Glomerular Filtration ◽  
Sodium Excretion ◽  
Filtration Rate ◽  
Sodium Intake ◽  
Dietary Sodium ◽  
Control Group ◽  
Phosphate Excretion

1. The influence of dietary sodium intake on the glomerular filtration rate (GFR/nephron) and potassium and phosphate excretion was examined at three stages of progressive chronic renal failure produced in rats by sequential partial nephrectomies. 2. The adaptive increased sodium excretion per nephron in the control group receiving a constant sodium intake did not occur in the experimental group that had a gradual reduction of dietary sodium in direct proportion to the fall in GFR. 3. Despite the difference in sodium excretion, the increase in GFR/nephron, the daily variation in the amount of potassium and phosphate excreted, the increase in potassium and phosphate excretion per unit nephron, and the plasma potassium and phosphate concentrations were the same in the two groups. 4. The concept of ‘autonomous adaptation’ in chronic renal failure is presented.

scholarly journals Coping Mechanisms and Stress Adaptation in Chronic Kidney Failure Patients Underwent Hemodialysis Therapy in RSUD Waled Kabupaten Cirebon

2020 ◽  
Vol 7 (2) ◽  
pp. 27-31
Author(s):  
Bambang Adi Purnomo ◽  
Yani Kamasturyani ◽  
Cecep Wahyudin
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Failure ◽  
Chronic Kidney Failure ◽  
Coping Mechanisms ◽  
Rank Test ◽  
Stress Adaptation ◽  
P Value ◽  
Cross Sectional ◽  
Spearman Rank

Chronic renal failure is a disease that results in a progressive and gradual decline in renal function that requires hemodialysis therapy. In Indonesia, there were 198,575 patients chronic kidney failure in 2018. The number of undergoing hemodialysis therapy is 132,142 patients. The hemodialysis routine causes tension, anxiety, stress and depression in patient. The purpose of this study was to determine the relationship between coping mechanisms and stress adaptation in chronic renal failure patients undergoing hemodialysis therapy ant Waled Hospital. The method of this research was descriptive correlational with a cross sectional approach. This research used purposive sampling technique amounted to 79 respondents. The instrument of this research was a questionnaire Jaloweic Coping Scale (JCS) and stress adaptation questionnaire. Data analysis used the spearman rank test. Place of research at Waled Hospital, Cirebon Regency during July 2020.  The result showed that most respondents had an adaptive category as many as 55 adaptation showed the results of most respondents had an adaptive category as many as 55 respondents with a percentage (69.6%). The spearman rank test showed p value <α and r<1, which means that there was a moderate an positive relationship between coping mechanisms and stress adaptation (p value=0,000 < α=0.05 and r=0.593). The is a relationship between coping mechanisms and stress adaptation in chronic renal failure patients undergoing hemodialysis therapy. The better coping mechanism is carries out, the adaptive stress that arises will be adaptive so that the patient can adjust and be able to cope with the stress he is experiencing.

Renal Tubular Protein Degradation of Radiolabelled Aprotinin (Trasylol) in Patients with Chronic Renal Failure

1993 ◽  
Vol 85 (6) ◽  
pp. 733-736 ◽  
Author(s):  
R. Rustom ◽  
J. S. Grime ◽  
P. Maltby ◽  
H. R. Stockdale ◽  
M. J. Jackson ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Chronic Renal Failure ◽  
Glomerular Filtration ◽  
Normal Renal Function ◽  
Filtration Rate ◽  
Renal Uptake ◽  
The Mean ◽  
Renal Tubular

1. The new method developed to measure renal tubular degradation of small filtered proteins in patients with normal renal function, using radio-labelled aprotinin (Trasylol) (R. Rustom, J. S. Grime, P. Maltby, H. R. Stockdale, M. Critchley, J. M. Bone. Clin Sci 1992; 83, 289–94), was evaluated in patients with chronic renal failure. 2. Aprotinin was labelled with either 99mTc (40 MBq) or 131I (0.1 MBq), and injected intravenously in nine patients, with different renal pathologies. 51Cr-EDTA clearance (corrected for height and weight) was 40 + 5.4 (range 11.2-81) ml min−1 1.73 m−2. Activity in plasma and urine was measured over 24–48 h, and chromatography on Sephadex-G-25-M was used to separate labelled aprotinin from free 99mTcO4− or 131I−. Renal uptake was measured for 99mTc-labelled aprotinin only. 3. The volume of distribution was 20.2 + 2.3 litres. Chromatography showed all plasma activity as undegraded aprotinin, and urine activity only as the free labels (99mTcO4− or 131I−). 4. As in patients with normal renal function, activity in the kidney appeared promptly, with 5.7 + 2.5% of the dose detected even at 5 min. Activity rose rapidly to 9.4 + 1.6% of dose after 1.5 h, then more slowly to 15.0 + 0.5% of dose at 4.5 h, and even more slowly thereafter, reaching 24.1 + 2.8% of dose at 24 h. Extra-renal uptake was again insignificant, and both 99mTcO4− and 131I− appeared promptly in the urine, with similar and uniform rates of excretion over 24 h. 5. Both tubular uptake at 24 h and the rate of tubular metabolism over 24 h were lower than in the patients with normal renal function studied previously, but only the rate of tubular metabolism was directly related to the glomerular filtration rate (r = 0.75, P <0.02). 6. Correction for the reduced glomerular filtration rate yielded values for both tubular uptake (0.67 + 0.14 versus 0.32 + 0.03% of dose/ml of glomerular filtration rate, P <0.005), and tubular metabolism (0.033 + 0.07 versus 0.015 + 0.001% of dose h−1 ml−1 of glomerular filtration rate, P <0.005) that were higher by comparison with those for patients with normal renal function studied previously. 7. Fractional renal degradation of 99mTc-aprotinin (in h−1), derived from the mean rate of urinary excretion of the free isotope over a given interval, divided by the mean cumulative kidney uptake over the same interval, also fell steeply early, and then more slowly to 0.07 + 0.01 h−1 at 14.25 h (between 4.5 and 24 h). 8. It is concluded that the method described previously is also suitable in patients with chronic renal failure, allowing further research into renal disease progression.

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