scholarly journals Effects of Curcuma Longa and Galega Orientalis Herbal Remedies on Homeostatic Renal Functions in Rats with Diabetes Mellitus and Acute Renal Failure

2019 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Functional State ◽  
Curcuma Longa ◽  
Hypoglycemic Effect ◽  
Herbal Remedies ◽  
Water Loading ◽  
Renal Functions ◽  
Galega Orientalis

Aim: To study the effects of phytopreparations Curcuma longa and Galega orientalis on homeostatic renal functions in rats with diabetes mellitus (DM) and acute renal failure (ARF) models. Materials and methods: The experiments were performed in 2 series on male Wistar rats (n = 60) with a model of diabetes mellitus (the 1-st one) and acute renal failure (the 2-nd one). In both series, the animals were divided into 3 groups: rats of the 1-st group were kept on standard feed, the rats of the other groups were got additionally to the feed turmeric (the 2-nd group) or galega (the 3-d group) (2% of feed weight). On the 3-d day of the experiment, the study of diuretic and ionuretic renal functions on an empty stomach and after water loading was performed. The concentration of ions in urine and plasma was determined by flame photometry; osmotic concentration of biological fluids - by cryoscopy; blood biochemical parameters– by colorimetric method. Results: In diabetic against both at the background and following water loading polyuria compared to the control animals was observed. Intake of Curcuma longa resulted in a slight decrease of polyuria, but an increase in the Na+ and K+ concentration in the urine. It has been shown that turmeric and galega have a hypoglycemic effect and contribute to the normalization of plasma homeostatic parameters by improving the functional state of the kidneys. This effect was most pronounced following turmeric intake. In rats with acute renal failure both phytopreparations did not cause the changes in renal functions. Conclusion: Phytopreparations of turmeric and galega in diabetes have a hypoglycemic effect, contribute to the normalization of plasma homeostatic parameters and improve the functional state of the kidneys. In acute renal failure, these herbal remedies have almost no effect on osmotic and ion-regulating responses.

Effect of Curcuma longa and Galega orientalis on renal function in rats with experimental diabetes mellitus and acute renal failure

2019 ◽  
pp. 88-95
Author(s):  
Р.И. Айзман ◽  
А.П. Козлова ◽  
Е.И. Гордеева ◽  
М.С. Головин ◽  
Г.А. Корощенко ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Experimental Diabetes ◽  
Curcuma Longa ◽  
Diabetic Rats ◽  
Standard Diet ◽  
Experimental Diabetes Mellitus ◽  
Galega Orientalis

Цель - исследование влияния куркумы длинной и галеги восточной на осмо- и ионорегулирующую функции почек крыс при аллоксан-индуцированном сахарном диабете и острой почечной недостаточности в эксперименте. Методика. Эксперименты выполнены на самцах крыс Wistar (n=70) с моделью сахарного диабета (1-я серия) и острой почечной недостаточности (2-я серия). В обеих сериях животные были поделены на 3 группы: крыс 1-й группы содержали на стандартном корме, крысам остальных групп в корм добавляли куркуму (2-я группа) или галегу (3-я группа) (2% от массы корма). На 7-е сут эксперимента проводили исследование диуретической и ионоуретической функций почек натощак и после 5% водной нагрузки. Концентрацию ионов в моче и плазме определяли методом пламенной фотометрии; осмотическую концентрацию биологических жидкостей - методом криоскопии; биохимические показатели крови - колориметрическим методом. Результаты. У животных с сахарным диабетом фоновый диурез, а также экскреция натрия и калия были статистически значимо выше, чем у контрольных животных. При острой почечной недостаточности наблюдался более низкий уровень диуреза и ионоуреза, особенно после водной нагрузки. Прием куркумы и галеги вызывал улучшение осмо- и ионорегулирующей функции почек у крыс с сахарным диабетом, и практически не влиял на эти функции почек при острой почечной недостаточности. Заключение. При сахарном диабете оба фитопрепарата вызывали понижение концентрации глюкозы, креатинина, мочевины и улучшение ионно-осмотических показателей плазмы крови, при этом эффект куркумы был выражен отчетливее. При острой почечной недостаточности эти фитопрепараты не давали описанного эффекта. Aim. To study effects of the phytomedicines, Curcuma longa and Galega orientalis, on osmosis- and ion-regulating renal functions in rats with experimental diabetes mellitus (DM) and acute renal failure (ARF). Methods. Experiments were performed in two series on Wistar male rats (n=70) with modeled diabetes mellitus (series 1) and acute renal failure (series 2). In each series, the animals were divided into 3 groups, 1) rats of group 1 receiving a standard diet; 2) rats of groups 2 and 3 receiving a standard diet supplemented with turmeric or galega (2% of food weight), respectively. On the 7th day of the experiment, the diuretic and ionuretic renal function was studied in fasting state and after 5% water loading. Concentrations of ions in urine and plasma were determined by flame photometry; osmotic concentrations of biological fluids were measured by cryoscopy; blood biochemical parameters were measured by colorimetry. Results. In diabetic rats, background diuresis and sodium and potassium excretion were significantly higher than in the control animals. In rats with acute renal failure, diuresis and ionuresis were significantly lower, particularly after the water loading. Turmeric and galega supplementation improved the osmotic and ion-regulating renal function in diabetic rats and left practically unchanged these functions in rats with acute renal failure. Conclusion. In rats with diabetes mellitus, both herbal remedies reduced concentrations of glucose, creatinine, and urea and improved ion-osmotic parameters of blood plasma with a more pronounced effect of turmeric. In acute renal failure, these phytomedicines did not produce the described effects.

Uroangiographic Contrast Media-Induced Nephropathy: Correlations between Their Physicochemical Properties and Renal Damage

2005 ◽  
Vol 72 (4) ◽  
pp. 446-456
Author(s):  
C. Alberti ◽  
M. Piovano ◽  
A. Tizzani
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Chronic Renal Failure ◽  
Contrast Media ◽  
Renal Damage ◽  
Contrast Material ◽  
Vasoactive Mediators ◽  
Adequate Hydration ◽  
Hospital Acquired

Contrast media-induced nephropathy (CN) is an important cause of hospital-acquired acute renal failure. Patients with both diabetes mellitus and renal impairment are at high risk. CN pathophysiology involves activation of the tubulo-glomerular feedback and vasoactive mediators such as renin-angiotensin 2, endothelin, adenosine, ADH, etc. The risk of CN can be minimized by the use of non-ionic, low or isoosmolar, contrast material, adequate hydration and prophylactic pharmacological measures. In patients with chronic renal failure who are undergoing arteriography (e.g. coronary angiography and angioplasty), periprocedural hemofiltration appears effective in preventing further renal damage due to contrast agents.

Hepatitis A-Induced Diabetes Mellitus, Acute Renal Failure, and Liver Failure

1999 ◽  
Vol 317 (6) ◽  
pp. 419 ◽  
Author(s):  
David L. Vesely ◽  
Roger W. Dilley ◽  
William C. Duckworth ◽  
Frederick F. Paustian
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Liver Failure ◽  
Hepatitis A

scholarly journals Effect of Lipin as a basis of liposomal Lipoflavon on the functional state of kidneys in rats under a model of pathology

2014 ◽  
Vol 18 (3 (71)) ◽  
Author(s):  
O. M. Horoshko
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Functional State ◽  
Equivalent Dose ◽  
Single Application ◽  
The Impact

The impact of Lipin as part of Lipoflavon on renal function in animals under conditions of glycerol model of nephropathy was analysed. As a result, it was determined that after a single application, Lipoflavon can improve the renal function under conditions of acute renal failure. At the same time Lipin in equivalent dose of that in Lipoflavon does not influence the renal function.

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