scholarly journals The Role of Nitric Oxide in Stem/Progenitor Cells

2018 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Nitric Oxide ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune System ◽  
Progenitor Cells ◽  
Embryonic Stem ◽  
Clinical Value ◽  
Immune System Diseases ◽  
Function Mechanism

The research on nitric Oxide (NO) and stem cells are the focus in recent years. However, seldom do people conclude the function, mechanism and clinical value of NO in various stem cells including embryonic stem cells (ESCs), endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs) and neural stem cells (NSCs). In the present review, we evaluate the recent studies on NO in different stem cells and display the latest progresses of NO therapy for tumor, cardiovascular, neurologic and immune system diseases by stem cells.

Mesenchymal Stem Cell Derived-Exosomes as Effective Factors in Reducing Cytokine Storm Symptoms of COVID-19

2021 ◽  
Vol 28 ◽  
Author(s):  
Amir Hossein Kheirkhah ◽  
Seyed Hossein Shahcheraghi ◽  
Malihe lotfi ◽  
Marzieh lotfi ◽  
Sanaz Raeisi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune System ◽  
Host Immune System ◽  
Cytokine Storm ◽  
Infection Transmission ◽  
Effective Factors ◽  
Different Types ◽  
Immune System Modulation

: Given that conventional therapies are ineffective for COVID-19, obtained exosomes from stem cells have been proposed as a sustainable and effective treatment. Exosomes are subsets with lengths between 30 and 100 nanometers, and they can be secreted by different cells. Exosomes are containing different types of miRNAs, mRNAs, and different proteins. The role of immune system modulation of exosomes of mesenchymal stem cells has been studied and confirmed in more than one study. Exosome miRNAs detect and reduce cytokines that cause cytokine storms such as IL-7, IL-2, IL-6, etc. These miRNAs include miR-21, miR-24, miR-124, miR-145, etc. The risks associated with treatment with exosomes from different cells are relatively small compared to other treatments because transplanted cells do not stimulate the host immune system and also has reduced infection transmission. Due to the ineffectiveness of existing drugs in reducing inflammation and preventing cytokine storms, the use of immune-boosting systems may be suggested as another way to control cytokine storm.

Embryonic Stem Cells: The Role of Nitric Oxide in Regulating Cell Differentiation, Self-Renewal, and Apoptosis

2011 ◽  
pp. 359-369 ◽  
Author(s):  
Juan R. Tejedo ◽  
Gladys M. Cahuana ◽  
Francisco J. Bedoya ◽  
Rafael Tapia-Limonchi
Keyword(s):  
Nitric Oxide ◽  
Stem Cells ◽  
Cell Differentiation ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Self Renewal

The role of nitric oxide in cardiomyogenesis using embryonic stem cells

2004 ◽  
Vol 23 (2) ◽  
pp. S173
Author(s):  
L.L Shears ◽  
S Kanno ◽  
R.L Kormos ◽  
K.R McCurry ◽  
T.R Billiar
Keyword(s):  
Nitric Oxide ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem

scholarly journals Evolutionarily Conserved Role of Nucleostemin: Controlling Proliferation of Stem/Progenitor Cells during Early Vertebrate Development

2006 ◽  
Vol 26 (24) ◽  
pp. 9291-9301 ◽  
Author(s):  
Chantal Beekman ◽  
Massimo Nichane ◽  
Sarah De Clercq ◽  
Marion Maetens ◽  
Thomas Floss ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Embryonic Stem Cells ◽  
Progenitor Cells ◽  
Control Cell ◽  
Embryonic Stem ◽  
Physiological Role ◽  
Specific Gene

ABSTRACT Nucleostemin (NS) is a putative GTPase expressed preferentially in the nucleoli of neuronal and embryonic stem cells and several cancer cell lines. Transfection and knockdown studies indicated that NS controls the proliferation of these cells by interacting with the p53 tumor suppressor protein and regulating its activity. To assess the physiological role of NS in vivo, we generated a mutant mouse line with a specific gene trap event that inactivates the NS allele. The corresponding NS −/− embryos died around embryonic day 4. Analyses of NS mutant blastocysts indicated that NS is not required to maintain pluripotency, nucleolar integrity, or survival of the embryonic stem cells. However, the homozygous mutant blastocysts failed to enter S phase even in the absence of functional p53. Haploid insufficiency of NS in mouse embryonic fibroblasts leads to decreased cell proliferation. NS also functions in early amphibian development to control cell proliferation of neural progenitor cells. Our results show that NS has a unique ability, derived from an ancestral function, to control the proliferation rate of stem/progenitor cells in vivo independently of p53.

scholarly journals The Vascular Microenvironment and Systemic Sclerosis

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Tracy Frech ◽  
Nathan Hatton ◽  
Boaz Markewitz ◽  
Mary Beth Scholand ◽  
Richard Cawthon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Systemic Sclerosis ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Organ Damage ◽  
Vascular Cell ◽  
Nail Bed ◽  
Vascular Cell Senescence

The role of the vascular microenvironment in the pathogenesis Systemic Sclerosis (SSc) is appreciated clinically as Raynaud's syndrome with capillary nail bed change. This manifestation of vasculopathy is used diagnostically in both limited and diffuse cutaneous subsets of SSc, and is thought to precede fibrosis. The degree of subsequent fibrosis may also be determined by the vascular microenvironment. This paper describes why the vascular microenvironment might determine the degree of end-organ damage that occurs in SSc, with a focus on vascular cell senescence, endothelial progenitor cells (EPC) including multipotential mesenchymal stem cells (MSC), pericytes, and angiogenic monocytes. An explanation of the role of EPC, pericytes, and angiogenic monocytes is important to an understanding of SSc pathogenesis. An evolving understanding of the vascular microenvironment in SSc may allow directed treatment.

scholarly journals Role of Nitric Oxide Signaling in Endothelial Differentiation of Embryonic Stem Cells

2010 ◽  
Vol 19 (10) ◽  
pp. 1617-1626 ◽  
Author(s):  
Ngan F. Huang ◽  
Felix Fleissner ◽  
John Sun ◽  
John P. Cooke
Keyword(s):  
Nitric Oxide ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Endothelial Differentiation ◽  
Nitric Oxide Signaling

scholarly journals Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells

2008 ◽  
Vol 105 (48) ◽  
pp. 18924-18929 ◽  
Author(s):  
K. Mujoo ◽  
V. G. Sharin ◽  
N. S. Bryan ◽  
J. S. Krumenacker ◽  
C. Sloan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Myocardial Cells ◽  
Nitric Oxide Signaling ◽  
Signaling Components
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