Pleiotropic effects of omega-3 polyunsaturated fatty acids in complex treatment of patients with comorbidity of chronic pancreatitis and stable coronary artery disease

Polyunsaturated fatty acids (PUFAs) of the class omega-3 are the substances that have a polytropic effect on different processes in the human body. The aim is to study the effectiveness of course treatment with omega-3 PUFAs for correction of lipid, prooxidative-antioxidant disorders and imbalance in the kallikrein-kinin system (KKS) in patients with a comorbidity of chronic pancreatitis (CP) and stable coronary artery disease (SCAD). The study included 90 patients with CP combined with SCAD who were divided into two groups (depending on the treatment program): I group (45 patients) received standard protocol treatment (SPT); group II (45 patients) additionally to SPT received omega-3 PUMAs (Omacor) 2 capsules (2000 mg) during one month. It has been shown that the addition of omega-3 PUMAs to the treatment of patients with comorbidity of CP and SCAD is more conducive to improving the lipid and prooxidant-antioxidant states and KKS indices than the standard basic therapy.