Effects of extra virgin olive oil and pecan nuts on plasma fatty acids in patients with stable coronary artery disease

Nutrition ◽  
2021 ◽  
pp. 111411
Author(s):  
Aline Ramos de Araújo ◽  
Geni Rodrigues Sampaio ◽  
Lucas Ribeiro da Silva ◽  
Vera Lúcia Portal ◽  
Melissa Medeiros Markoski ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Olive Oil ◽  
Stable Coronary Artery Disease ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Plasma Fatty Acids ◽  
Artery Disease

scholarly journals Pleiotropic effects of omega-3 polyunsaturated fatty acids in complex treatment of patients with comorbidity of chronic pancreatitis and stable coronary artery disease

2018 ◽  
Vol 39 (1) ◽  
pp. 22-27
Author(s):  
L. S. Babinets ◽  
N. A. Melnyk
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Chronic Pancreatitis ◽  
Coronary Artery ◽  
Polyunsaturated Fatty Acids ◽  
Stable Coronary Artery Disease ◽  
Omega 3 ◽  
Kinin System ◽  
Artery Disease ◽  
Kallikrein Kinin System

Polyunsaturated fatty acids (PUFAs) of the class omega-3 are the substances that have a polytropic effect on different processes in the human body. The aim is to study the effectiveness of course treatment with omega-3 PUFAs for correction of lipid, prooxidative-antioxidant disorders and imbalance in the kallikrein-kinin system (KKS) in patients with a comorbidity of chronic pancreatitis (CP) and stable coronary artery disease (SCAD). The study included 90 patients with CP combined with SCAD who were divided into two groups (depending on the treatment program): I group (45 patients) received standard protocol treatment (SPT); group II (45 patients) additionally to SPT received omega-3 PUMAs (Omacor) 2 capsules (2000 mg) during one month. It has been shown that the addition of omega-3 PUMAs to the treatment of patients with comorbidity of CP and SCAD is more conducive to improving the lipid and prooxidant-antioxidant states and KKS indices than the standard basic therapy.

scholarly journals Impact of free fatty acids on prognosis in coronary artery disease patients under different glucose metabolism status

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Jing-Lu Jin ◽  
Ye-Xuan Cao ◽  
Hui-Hui Liu ◽  
Hui-Wen Zhang ◽  
Yuan-Lin Guo ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Coronary Artery ◽  
Glucose Metabolism ◽  
Free Fatty Acids ◽  
Cox Model ◽  
Stable Coronary Artery Disease ◽  
P Value ◽  
Significant Difference ◽  
Artery Disease

Abstract Background The aim of the present study is to examine the effects of free fatty acids (FFAs) on major cardiovascular events (MACEs) in patients with stable coronary artery disease (CAD) and different glucose metabolism status. Methods In this study, we consecutively enrolled 5443 patients from March 2011 to May 2015. Patients were categorized according to both status of glucose metabolism status [diabetes mellitus (DM), pre-diabetes (Pre-DM), normal glycaemia regulation (NGR)] and FFAs levels. All subjects were followed up for the occurrence of the MACEs. Results During a median of 6.7 years’ follow-up, 608 MACEs occurred. A twofold higher FFAs level was independently associated with MACEs after adjusting for confounding factors [Hazard Ratio (HR): 1.242, 95% confidence interval (CI) 1.084–1.424, p value = 0.002]. Adding FFAs to the Cox model increased the C-statistic by 0.015 (0.005–0.027). No significant difference in MACEs was observed between NGR and Pre-DM groups (p > 0.05). When patients were categorized by both status of glucose metabolism and FFAs levels, medium and high FFAs were associated with significantly higher risk of MACEs in Pre-DM [1.736 (1.018–2.959) and 1.779 (1.012–3.126), all p-value < 0.05] and DM [2.017 (1.164–3.494) and 2.795 (1.619–4.824), all p-value < 0.05]. Conclusions The present data indicated that baseline FFAs levels were associated with the prognosis in DM and Pre-DM patients with CAD, suggesting that FFAs may be a valuable predictor in patients with impaired glucose metabolism.

Effects of supplementing a healthy diet with pecan nuts or extra-virgin olive oil on inflammatory profile of patients with stable coronary artery disease: a randomized clinical trial

2021 ◽  
pp. 1-27
Author(s):  
Camila Weschenfelder ◽  
Catarina Bertaso Andreatta Gottschall ◽  
Melissa Medeiros Markoski ◽  
Vera Lúcia Portal ◽  
Alexandre Schaan de Quadros ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Clinical Trial ◽  
Olive Oil ◽  
Inflammatory Markers ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Study Groups ◽  
Healthy Diet ◽  
Inflammatory Profile ◽  
Artery Disease

Abstract The consumption of nuts and extra-virgin olive oil has been associated with suppression of inflammatory pathways that contribute to atherosclerosis, but its role on the modulation of the inflammatory profile in patients with established coronary artery disease (CAD) is unclear. The aim of this study was to evaluate the effects of adding pecan nuts or extra-virgin olive oil to a healthy diet on inflammatory markers in patients with stable CAD. In this randomized clinical trial, 204 patients were enrolled to three study groups: 67 to control group (CG: healthy diet), 68 to pecan nuts group (PNG: 30g/day of pecans + healthy diet) and 69 to extra-virgin olive oil group (OOG: 30ml/day of extra-virgin olive oil + healthy diet). High-sensitivity C-reactive protein (hs-CRP, in mg/L), fibrinogen (mg/dL), interleukins (IL) 2, 4, 6, 10 (pg/mL) and interferon-γ (IFN-γ, in pg/mL), IL-6/IL-10, IL-2/IL-4 and INF-γ/IL-4 ratios were evaluated at baseline and after the follow-up (12 weeks). As main results, after adjustment for sex, statin used and relative body weight variation, there were no differences between groups regarding inflammatory markers at the end of the study. IL-6 levels (primary outcome) were reduced in 12 weeks when compared to baseline in all study groups [CG: difference: −0.593 (SE = 0.159) pg/dL; PNG: difference: −0.335 (SE = 0.143) pg/dL; OOG: IL-6 difference: −0.325 (SE = 0.143) pg/dL]. In conclusion, there was no significant effect of including pecan nuts or extra virgin olive oil to a healthy diet on inflammatory markers in individuals with CAD.

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