scholarly journals Determining the molecular-weight and interfacial properties of chitosan built nanohydrogel for controlled drug delivery applications

2019 ◽  
Vol 9 (6) ◽  
pp. 4452-4457 ◽  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Aqueous Medium ◽  
Diblock Copolymers ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Interfacial Properties ◽  
Radical Copolymerization ◽  
Free Radical Copolymerization ◽  
Drug Delivery Applications

Recent development in polymeric nanohydrogel demands surface modification, interfacial properties and determination of molecular weight for effective drug loading and release studies. Therefore, chitosan built nanohydrogel were synthesized via free radical copolymerization and functionalized with hydrophilic ligands to act as amphiphilic diblock copolymers in aqueous medium. The investigated properties like porosity (61- 73 %) , cross-linking density (20.38- 25.22), critical micelle concentration (CMC≈ 0.41- 0.62 g/L), thermodynamic of adsorption followed by micellization, and the molecular weight of chitosan built nanohydrogel (Mw ≈11.59- 13.05 x 105 (g/mol, determined by applying Debye plot) have been investigated as a new tool to understand the art and chemical identity of hydrogel at air- water interface in aqueous medium regarding controlled drug delivery applications.

Development and optimization of methotrexate-loaded lipid-polymer hybrid nanoparticles for controlled drug delivery applications

2017 ◽  
Vol 533 (1) ◽  
pp. 156-168 ◽  
Author(s):  
Nayab Tahir ◽  
Asadullah Madni ◽  
Vimalkumar Balasubramanian ◽  
Mubashar Rehman ◽  
Alexandra Correia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Drug Delivery Applications

Stimuli-responsive poly(ionic liquid) nanoparticles for controlled drug delivery

2020 ◽  
Vol 8 (35) ◽  
pp. 7994-8001 ◽  
Author(s):  
Beibei Lu ◽  
Gaoxin Zhou ◽  
Fan Xiao ◽  
Qianjun He ◽  
Jiaheng Zhang
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Spherical Nanoparticles ◽  
High Drug ◽  
Good Ability ◽  
Poly Ionic Liquid ◽  
High Drug Loading

A novel poly(ionic liquid) (PIL)-based block copolymer, which can self-assemble into spherical nanoparticles, high drug loading content, and good ability to inhibit tumors. Therefore, this copolymer shows great potential for drug delivery. 

scholarly journals Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 195 ◽  
Author(s):  
Catalina Paula Spatarelu ◽  
Anita-Laura (Radu) Chiriac ◽  
Bogdan Cursaru ◽  
Tanta-Verona Iordache ◽  
Ana-Mihaela Gavrila ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Natural Zeolite ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Preparation Conditions ◽  
Transmission Electron ◽  
Poly Ethylene

This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

Interfacial properties of POPC/GDO liquid crystalline nanoparticles deposited on anionic and cationic silica surfaces

2016 ◽  
Vol 18 (38) ◽  
pp. 26630-26642 ◽  
Author(s):  
Debby P. Chang ◽  
Aleksandra P. Dabkowska ◽  
Richard A. Campbell ◽  
Maria Wadsäter ◽  
Justas Barauskas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liquid Crystalline ◽  
Interfacial Properties ◽  
High Potential ◽  
Silica Surfaces ◽  
Drug Molecules ◽  
Hydrophilic Drug ◽  
Liquid Crystalline Nanoparticles ◽  
Drug Delivery Applications

Reversed lipid liquid crystalline nanoparticles (LCNPs) of the cubic micellar (I2) phase have high potential in drug delivery applications due to their ability to encapsulate both hydrophobic and hydrophilic drug molecules.

Sign in / Sign up

Export Citation Format

Share Document