Serological response of commercial dairy cattle to inactivated foot-and-mouth disease vaccine (type-O & A) in Nigeria

An observational study was conducted in a peri-urban dairy establishment in Jos South, Plateau State Nigeria to determine immune response of dairy cattle to commercial inactivated foot-and-mouth disease vaccine serotypes (O and A). Thirty seven Friesian cattle aged ?2years old with their crosses (15 selected pre-vaccination and 22 selected 21 days post-vaccination) were investigated for immune response to vaccination with an inactivated trivalent FMD vaccine containing serotypes O, A and SAT 2). Sera collected on day 0 pre-vaccination and 21 days post-vaccination was tested for structural protein antibodies to FMD serotypes O and A using the Solid Phase Competitive ELISA assay. The mean OD value for serum end point titre of FMD serotype O pre-vaccination was 11.64% with 6.67% (95%CI: 0.33 28.73) of the selected cattle being seropositive, at 21 days post-vaccination the mean OD value in selected cattle was 52.83% with 68.18% (95%CI: 46.95 84.89) of the selected cattle seropositive. For the FMD serotype A, 26.67% (95%CI: 9.10 52.53) of the selected cattle were seropositive pre-vaccination with a mean OD value of 29.21% and by 21 days post-vaccination, 72.73% (95%CI: 51.67 88.13) of the selected cattle were seropositive with a mean OD value of 61.70%. Serological response to vaccination improved in most selected cattle by 21 days post-vaccination. This study result has indicated that commercial inactivated FMD vaccines used for the prophylactic control of FMD in commercial dairy farm in Nigeria provoked immune response after a single shot.Asian J. Med. Biol. Res. June 2015, 1(2): 163-168

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The serological response against foot and mouth disease virus elicited by repeated vaccination of dairy cattle

Vaccine ◽

10.1016/j.vaccine.2016.08.054 ◽

2016 ◽

Vol 34 (41) ◽

pp. 4920-4926 ◽

Cited By ~ 2

Author(s):

Ehud Elnekave ◽

Aldo Dekker ◽

Phaedra Eble ◽

Froukje van Hemert-Kluitenberg ◽

Boris Gelman ◽

...

Keyword(s):

Dairy Cattle ◽

Disease Virus ◽

Foot And Mouth Disease ◽

Mouth Disease ◽

Serological Response ◽

Mouth Disease Virus ◽

Foot And Mouth

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A comparative study on the immune response of sheep to foot and mouth disease virus vaccine type Asia-1 prepared with different inactivants and adjuvants

Comparative Immunology Microbiology and Infectious Diseases ◽

10.1016/0147-9571(92)90110-d ◽

1992 ◽

Vol 15 (2) ◽

pp. 117-124 ◽

Cited By ~ 4

Author(s):

S.P. Nair ◽

A.K. Sen

Keyword(s):

Immune Response ◽

Comparative Study ◽

Disease Virus ◽

Virus Vaccine ◽

Foot And Mouth Disease ◽

Mouth Disease ◽

Mouth Disease Virus ◽

Vaccine Type ◽

Foot And Mouth

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Effect of Foot-and-Mouth Disease Vaccination on Acute Phase Immune Response and Anovulation in Hanwoo (Bos taurus coreanae)

Vaccines ◽

10.3390/vaccines9050419 ◽

2021 ◽

Vol 9 (5) ◽

pp. 419

Author(s):

Daehyun Kim ◽

Joonho Moon ◽

Jaejung Ha ◽

Doyoon Kim ◽

Junkoo Yi

Keyword(s):

Immune Response ◽

Artificial Insemination ◽

Bos Taurus ◽

Foot And Mouth Disease ◽

Test Group ◽

Mouth Disease ◽

Control Group ◽

Amyloid A ◽

Mouth Disease Virus ◽

Foot And Mouth

Vaccination against foot-and-mouth disease is the most common method for preventing the spread of the disease; the negative effects include miscarriage, early embryo death, lower milk production, and decreased growth of fattening cattle. Therefore, in this study, we analyze the side effects of vaccination by determining the acute immune response and ovulation rate after vaccinating cows for foot-and-mouth disease. The test axis was synchronized with ovulation using 100 Hanwoo (Bos taurus coreanae) cows from the Gyeongsangbuk-do Livestock Research Institute; only individuals with estrus confirmed by ovarian ultrasound were used for the test. All test axes were artificially inseminated 21 days after the previous estrus date. The control group was administered 0.9% normal saline, the negative control was injected intramuscularly with lipopolysaccharide (LPS; 0.5 µg/kg), and the test group was administered a foot-and-mouth disease virus vaccine (FMDV vaccine; bioaftogen, O and A serotypes, inactivated vaccine) 2, 9, and 16 days before artificial insemination. White blood cells and neutrophils increased significantly 1 day after vaccination, and body temperature in the rumen increased for 16 h after vaccination. Ovulation was detected 1 day after artificial fertilization by ovarian ultrasound. The ovulation rates were as follows: control 89%, LPS 60%, FMDV vaccine (−2 d) 50%, FMDV vaccine (−9 d) 75%, and FMDV vaccine (−16 d) 75%. In particular, the FMDV vaccine (−2 d) test group confirmed that ovulation was delayed for 4 days after artificial insemination. In addition, it was confirmed that it took 9 days after inoculation for the plasma contents of haptoglobin and serum amyloid A to recover to the normal range as the main acute immune response factors. The conception rate of the FMDV vaccine (−2 d) group was 20%, which was significantly lower than that of the other test groups.

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