scholarly journals Reproductive risk factors and breast cancer: a case control study from rural India

2015 ◽  
Vol 14 (3) ◽  
pp. 258-264 ◽  
Author(s):  
Vaishali R Mohite ◽  
Asha K Pratinidhi ◽  
Rajsinh Vishwasrao Mohite
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Feeding ◽  
Menopausal Status ◽  
Hormonal Contraceptives ◽  
Reproductive Risk ◽  
History Of ◽  
Reproductive Risk Factors ◽  
Post Menopausal ◽  
Strength Of Association

Background: Breast cancer is the most common type of cancer in women and is influenced by reproductive factors perceived by women worldwide.Aims: To identify the reproductive risk factors of breast cancer in newly diagnosed cases and to find out the strength of association of the risk factors with the breast cancer. Material and Methods: A hospital based case-control study was conducted in Satara district, India during year 2009 to 2011 among newly diagnosed cases of breast cancer and matched controls. A total of 434 participants including 217 cases and 217 controls were enrolled by purposive sampling technique from selected hospitals of study area. The information was collected by employing pre-tested questionnaire by utilizing interview method. Statistical Analysis used: Descriptive statistics, Odds ratio and Chi-square test was used to find out strength of association and statistical significant difference. Results: Highest proportion [31.80%] breast cancer cases was in age group 40-49 years with lowest age of 25 years at diagnosis of the disease. A very high proportion of both cases [88.02%] and controls [67.28%] were Hindu by religion and were from rural residence. Maximum proportion of breast cancer cases were housewives [63.59%], literate [71.42%] and from upper economic class [56.68%]. The proportions of cases were higher as compared to the controls with respect to risk factors like unmarried status, nulliparity, history of abortion, post menopausal status, absence of breast feeding and the history of exposure to hormonal contraceptives. The risk of getting breast cancer as indicated by Odds ratio was 8 times higher in unmarried women, 2.8 times in nulliparous women, 2.4 times with post menopausal status, 10.4 times with absence of breast feeding, 1.5 times with exposure to hormonal contraceptives and 4.5 times with history of ovarian disease respectively. Conclusion: The reproductive risk factors such as unmarried status of women, nulliparity, menopause, absence of breast feeding, history of ovarian disease and use of contraceptives were strongly associated with breast cancer.Bangladesh Journal of Medical Science Vol.14(3) 2015 p.258-264

scholarly journals Determinants of p14/ARF methylation in healthy females: association with reproductive and non-reproductive risk factors of breast cancer

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Ghada M. Ezzat ◽  
Mahmoud H. El-Shoeiby
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Family History ◽  
Cancer Risk Factors ◽  
Reproductive Risk ◽  
Specific Pcr ◽  
History Of ◽  
Reproductive Risk Factors ◽  
The Impact ◽  
Healthy Females

Abstract Background DNA methylation is associated with the risk factors of breast cancer. However, the impact of the reproductive and non-reproductive risk factors of breast cancer on p14/ARF methylation is not well known. Therefore, we investigated the relationships between p14/ARF methylation percentage and risk factors of breast cancer including age, family history, obesity, and reproductive risk factors in 120 breast cancer-free subjects; 60 women with a first-degree family history of breast cancer and 60 age-matched women with no family history of breast cancer. Extracted DNA from the whole blood was bisulfite-treated by EZ DNA modification kit. Quantitative methylation of p14/ARF was analyzed by methylation-specific PCR then methylation percentage of p14/ARF was calculated. Results P14/ARF methylation percentage was not related to any of the risk factors of breast cancer except age. Our study showed that p14/ARF methylation percentage was significantly higher in females with age ≥ 40 years than in females with age <  40 years (p=0.029). Also, a positive significant correlation between the p14/ARF methylation percentage and age was detected (r = 0.285, p = 0.014). Furthermore, univariate regression analysis showed that the age is independently associated with high p14/ARF methylation percentage (β = 1. 46, p = 0.029). Conclusion Among healthy females, the age is strongly linked to the peripheral p14/ARF methylation percentage. The present study suggests that p14/ARF methylation is not associated with other breast cancer risk factors. These results need oncoming research on a large cohort to define the interactions between p14/ARF methylation and the risk factors of breast cancer.

Abstract 127: Hormonal and reproductive risk factors for fatal breast cancer.

2013 ◽  
Author(s):  
Elizabeth M. Poole ◽  
A. Heather Eliassen ◽  
Susan E. Hankinson ◽  
Bernard A. Rosner ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Reproductive Risk ◽  
Reproductive Risk Factors

Reproductive Risk Factors of Breast Cancer in Erbil

2019 ◽  
Vol 10 (10) ◽  
pp. 1975
Author(s):  
Sherwan Aziz ◽  
Abdulqadir Zangana ◽  
Namir Al-Tawil
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Reproductive Risk ◽  
Reproductive Risk Factors

Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers

1997 ◽  
Vol 123 (5) ◽  
pp. 272-279 ◽  
Author(s):  
Jenny Chang-Claude ◽  
Heiko Becher ◽  
Nancy Eby ◽  
Gunter Bastert ◽  
J&#x000FC;rgen Wahrendorf ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Brca1 Mutation ◽  
Age At Onset ◽  
Reproductive Risk ◽  
Mutation Carriers ◽  
Modifying Effect ◽  
Reproductive Risk Factors

scholarly journals Dysglycemia and a History of Reproductive Risk Factors

Diabetes Care ◽  
2008 ◽  
Vol 31 (8) ◽  
pp. 1635-1638 ◽  
Author(s):  
S. D. McDonald ◽  
S. Yusuf ◽  
P. Sheridan ◽  
S. S. Anand ◽  
H. C. Gerstein ◽  
...  
Keyword(s):  
Risk Factors ◽  
Reproductive Risk ◽  
History Of ◽  
Reproductive Risk Factors

scholarly journals Analisis Faktor Risiko Reproduksi yang Berhubungan dengan Kejadian Kanker Payudara pada Wanita

1970 ◽  
Vol 1 (2) ◽  
Author(s):  
Ardiana A ◽  
Hudayat Wijaya Negara ◽  
Ma'mun Sutisna
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
General Hospital ◽  
Cancer Incidence ◽  
Multivariate Analyses ◽  
Breast Cancer Incidence ◽  
Dominant Factor ◽  
Chi Square ◽  
Reproductive Risk ◽  
Reproductive Risk Factors

Kanker payudara paling banyak ditemui pada perempuan dan merupakan penyebab kematian kedua setelah kanker leher rahim.Penyebab kanker payudara tidak diketahui dengan jelas karena multifaktor. Bukti epidemiologi menunjukkan bahwa terdapat tiga faktor penyebab terjadinya kanker payudara yaitu faktor hormonal, faktor genetik dan faktor lingkungan. Provinsi Sumatera Utara menempati urutan kelima kejadian kanker payudara di antara seluruh provinsi yang ada di Indonesia. Tujuan penelitian ini adalah untuk menganalisis hubungan antara faktor risiko reproduksi dengan kejadian kanker payudara. Jenis penelitian ini adalah kasus kontrol dengan pendekatan retrospektif. Subjek penelitian adalah perempuan penderita kanker payudara yang mendapatkan perawatan dan pengobatan di Rumah Sakit Umum Pemerintah H.Adam Malik dan Rumah Sakit Umum Daerah dr.Pirngadi Medan. Jumlah sampel 100 responden yang terdiri dari 50 kasus dan 50 kontrol. Analisis yang digunakan adalah analisis bivariat menggunakan uji chi-square dan analisis multivariat menggunakan regresi logistik ganda. Hasil penelitian menunjukkan bahwa faktor risiko yang berhubungan dengan kejadian kanker payudara berdasarkan analisis bivariat adalah usia menarche (p=0.001), paritas (p=0.001), usia kehamilan pertama (p=0.001) dan menyusui (p=0.002). Pada analisis multivariat menunjukkan bahwa keempat faktor risiko yang diteliti secara statistik bermakna (p<0.05), yaitu usia menarche (OR=4,41;95%CI: 1,33 ̶14,63), paritas (OR=6,38;95%CI: 1,57–25,90), usia kehamilan pertama (OR=7,91;95%CI; 1,86−33,60) dan menyusui (OR=4,24;95%CI:1,22–14,76). Dapat disimpulkan bahwa faktor risiko reproduksi yang berhubungan dengan kejadian kanker payudara adalah usia menarche<12 tahun, paritas 1–2, usia kehamilan pertama 20–30 tahun dan tidak menyusui. Faktor risiko yang paling dominan dalam penelitian ini adalah usia kehamilan pertama.Kata kunci: Faktor risiko, kanker payudara, reproduksi AbstractBreast cancer is most commonly found in women, and is the second leading cause of death after cervical cancer. Due to its multifactorial nature, the cause of breast cancer is indeterminate. Epidemiological evidence suggests that there are 3 possible factors contributing to the occurrence of breast cancer, namely hormonal, genetic and environmental factors. North Sumatra is the 5th province having the highest breast cancer prevalence among all other provinces in Indonesia. The purpose of this study was to analyze various reproductive risk factors contributing to breast cancer incidence in women. The study was a retrospective case-control. Subjects were women with breast cancer who received care and treatment in H.Adam Malik General Hospital and dr.Pirngadi Medan General Hospital. The sample size was N=100 (n=50 – case group; n=50 – control group). The data were analyzed using bivariate analyses (Chi-square tests) and multivariate analyses (multiple logistic regressions). Bivariate analyses showed that reproductive risk factors associated with breast cancer were menarche period (p=0.001), parity (p=0.001), age of first pregnancy (p=0.001) and breastfeeding (p=0.002). Moreover, multivariate analyses showed statistically significant correlations (p <0.05) between the four reproductive risk factors and breast cancer incidence, including menarche period (OR=4.41, 95% CI: 1.33 ̶ 14.63), parity (OR=6.38, 95% CI : 1.57 ̶ 25.90), age of first pregnancy (OR=7.91, 95% CI: 1.86 to 33.60) and breastfeeding (OR= 4.24, 95% CI: 1.22 ̶ 14.76). In conclusion, the reproductive risks associated with breast cancer incidence in women were the menarche period of <12 years, parity of 1 ̶ 2 times, first pregnancy age of 20 ̶ 30 years old and non-breastfeeding status. In this study, the age of the first pregnancy was found to be the most dominant factor. Key words: Breast cancer, reproductive, risk factor

scholarly journals BREAST CANCER;

2014 ◽  
Vol 21 (06) ◽  
pp. 1128-1132
Author(s):  
Abeer Nisar ◽  
M Naim Siddiqi ◽  
Naveed ur Rehman ◽  
Raza ur Rahman
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Family History ◽  
Menopausal Status ◽  
Positive Family History ◽  
American Woman ◽  
Breast Cancer Patients ◽  
Civil Hospital ◽  
Early Menarche ◽  
History Of

Objective: To assess the risk factors for breast cancer in patients attending oncology OPD of civil hospital Karachi, Pakistan. Introduction: Breast cancer is the single largest cause of death among women1,2. The probability of American woman developing breast cancer in their life is 7 in 11. Studies from subcontinent show that the incidence of breast cancer is increasing, with an estimated 80,000 new cases diagnosed annually. Breast cancer is the second most common type of cancer after lung cancer in Pakistan and ranked first in women. Only 10% women are diagnosed, out of them, 75% women do not get treatment and die within 5 years6. Data from Pakistan about the risk factors or association is not only scanty but also does not comment on the use of fatty diet in breast cancer patients. Method: A cross-sectional descriptive study conducted at Oncology OPD of civil hospital Karachi (CHK) from October 2009 -April 2011. One Hundred and Fifty consecutive patients having histopathalogical diagnosis of breast cancer were assessed for different risk factors that included marital status, parity, age, menopausal status, family history of breast cancer, prolong use of oral contraceptives, breast feeding, , early menarche, trauma to the breast and fatty diet. Result: Mean age of patients was 48 years. Three fourth (73%) of these female were above the age of 40 years. Consumption of fatty diet was found in 62.67% while positive family history of breast cancer was present in 34% of the cases. Early menarche and being nulliparous were not as strong risk factors as in previous studies. Conclusions: Our study has highlighted the need of further exploration in this area that would not only help this population but also enhance our understanding of different risk factors. This will have important implications for the overall management of breast cancer.

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