scholarly journals Preparation and Evaluation of Paracetamol Effervescent Tablets under Normal and Exaggerated Storage Conditions

2015 ◽  
Vol 17 (1) ◽  
pp. 75-78
Author(s):  
Rehana Sultana ◽  
Krishna Sarker ◽  
Sakina Sultana
Keyword(s):  
Pharmaceutical Journal ◽  
Storage Conditions ◽  
Bench Mark ◽  
Content Uniformity ◽  
Cool Temperature ◽  
Performance Study ◽  
Long Term Performance ◽  
Term Performance ◽  
Preparation And Evaluation

A single blind study was conducted to prepare and evaluate paracetamol effervescent tablets. Potency, content uniformity, diameter, thickness and crushing strength of the prepared tablets were used as the bench mark parameters for quality assessment. Our results showed that all parameters met official values except for friability. The performance of the tablets in terms of duration of effervescence was investigated under high stresses of humidity as well as at low and high temperatures. The duration of the investigational period lasted for 3 days and results showed an increase in effervescence time in each case. In this study, the normal effervescence time at 111.00±14.22 seconds was changed to 286.13±55.18 seconds, 140.38±21.59 seconds and 158.63±26.14 seconds under high humidity, at refrigeration (representing cool temperature) and at high temperature, respectively. Here, a long term performance study was also conducted under normal storage conditions spanning a period of 60 days. Duration of effervescence on day 1 was 212.54±0.34 seconds, but at the end of 60 days the duration increased to 634.23±0.65 seconds. In the present study the changes in organoleptic properties were also evaluated. Results showed that the properties remained the same over a period of 60 days while the potency of the drug reduced from 99% to 95%. DOI: http://dx.doi.org/10.3329/bpj.v17i1.22320 Bangladesh Pharmaceutical Journal 17(1): 75-78, 2014

Steel bridge long-term performance research technology framework and research progress

2016 ◽  
Vol 20 (1) ◽  
pp. 51-68 ◽  
Author(s):  
Chunsheng Wang ◽  
Lan Duan ◽  
Musai Zhai ◽  
Yuxiao Zhang ◽  
Shichao Wang
Keyword(s):  
Base Material ◽  
Fatigue Performance ◽  
Research Progress ◽  
Steel Bridge ◽  
Performance Study ◽  
Research Technology ◽  
Study Results ◽  
Long Term Performance ◽  
Term Performance

To ensure structural sustainability, it is necessary to conduct steel bridge long-term performance study, including bridge design, evaluation, maintenance, and reinforcement technology. The research on steel bridge long-term performance is introduced in four aspects: (1) fatigue performance experimental study for full-scale orthotropic steel bridge decks in laboratory to study its fatigue failure mechanism, in order to improve fatigue design methodology and find rational reinforcement and maintenance method; (2) conducting steel bridge out-of-plane distortion-induced fatigue performance study, and developing cold reinforcement method; (3) performance study for base material and typical joint under long-term vehicle and environmental effect in aging steel bridges, and safety assessment and maintenance of existing steel bridge; (4) temperature gradient monitoring for steel box girder model to build the temperature design mode. Meantime, in-situ tests and monitoring are conducted for steel bridge long-term performance detection, assessment, and maintenance. The study results in this article build the research framework of steel bridge long-term performance preliminarily, which is the basis for steel bridge sustainable design, maintenance, and cold reinforcement methodology system.

scholarly journals 9975 Shipping Package: Performance of Alternate Materials for Long-Term Storage Application

2010 ◽  
Author(s):  
T. E. Skidmore ◽  
W. L. Daugherty ◽  
E. N. Hoffman
Keyword(s):  
Storage Conditions ◽  
Test Results ◽  
Savannah River ◽  
Long Term Storage ◽  
Additional Testing ◽  
Long Term Performance ◽  
Term Performance ◽  
River Site ◽  
Term Storage

The Model 9975 shipping package specifies the materials of construction for its various components. With the loss of availability of material for two components (cane fiberboard overpack and Viton® GLT O-rings), alternate materials of construction were identified and approved for use for transport (softwood fiberboard and Viton® GLT-S O-rings). The shipping packages are part of a long-term storage configuration at the Savannah River Site (SRS). Therefore, additional testing is in progress to verify satisfactory long-term performance of the alternate materials under storage conditions. The test results to date can be compared to results on the original materials of construction to draw preliminary conclusions on the performance of the replacement materials.

scholarly journals Long Term Performance Study of a Direct Methanol Fuel Cell Fed with Alcohol Blends

Energies ◽  
2013 ◽  
Vol 6 (1) ◽  
pp. 282-293 ◽  
Author(s):  
Teresa Leo ◽  
Miguel Raso ◽  
Emilio Navarro ◽  
Eleuterio Mora
Keyword(s):  
Fuel Cell ◽  
Direct Methanol Fuel Cell ◽  
Performance Study ◽  
Direct Methanol ◽  
Long Term Performance ◽  
Term Performance ◽  
Methanol Fuel Cell

scholarly journals Storage Conditions of Conjugated Reagents Can Impact Results of Immunogenicity Assays

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Robert J. Kubiak ◽  
Nancy Lee ◽  
Yuan Zhu ◽  
William R. Franch ◽  
Sophia V. Levitskaya ◽  
...  
Keyword(s):  
Storage Conditions ◽  
Drug Naïve ◽  
Consistent Performance ◽  
Storage Buffer ◽  
Long Term Performance ◽  
Immunogenicity Assays ◽  
Term Performance ◽  
Phosphate Buffered Saline ◽  
Time Evaluation

Consistent performance of anti-drug antibody (ADA) assays through all stages of clinical development is critical for the assessment of immunogenicity and interpretation of PK, PD, safety, and efficacy. The electrochemiluminescent assays commonly employed for ADA measurement use drug conjugated with ruthenium and biotin to bind ADA in samples. Here we report an association between high nonspecific ADA responses in certain drug-naïve individuals and the storage buffer of the conjugated reagents used in a monoclonal antibody ADA assay. Ruthenylated reagents stored in phosphate-buffered saline (PBS) buffer had increased levels of aggregate and produced variable and high baseline responses in some subjects. Reagents stored in a histidine-sucrose buffer (HSB) had lower aggregate levels and produced low sample responses. In contrast to PBS, conjugated reagents formulated in HSB remained low in aggregate content and in sample response variability after 5 freeze/thaw cycles. A reagent monitoring control (RMC) serum was prepared for the real-time evaluation of conjugated reagent quality. Using appropriate buffers for storage of conjugated reagents together with RMCs capable of monitoring of reagent aggregation status can help ensure consistent, long-term performance of ADA methods.

Fine Particle Mass Monitoring with Low-Cost Sensors: Corrections and Long-Term Performance Evaluation

2019 ◽  
Author(s):  
Carl Malings ◽  
Rebecca Tanzer ◽  
Aliaksei Hauryliuk ◽  
Provat K. Saha ◽  
Allen L. Robinson ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Fine Particle ◽  
Low Cost ◽  
Particle Mass ◽  
Long Term Performance ◽  
Term Performance
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