scholarly journals Hypofractionated Radiotherapy for Post-Operative Breast Cancer Patients at Delta Hospital - an Evaluation of Clinical Experience

2015 ◽  
Vol 3 (1) ◽  
pp. 4-8 ◽  
Author(s):  
Parvin Akhter Banu ◽  
Naheed Rukhsana ◽  
MA Jabber ◽  
Motiur Rahman ◽  
Sadiq R Malik
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Ductal Carcinoma ◽  
Therapy Group ◽  
Breast Conservation ◽  
Skin Toxicity ◽  
Hypofractionated Radiotherapy ◽  
Breast Cancer Patients ◽  
Acute Skin Toxicity

Background: As hypofractionated radiotherapy for post-operative breast cancer patients safe, effective and more convenient, it might be beneficial for patients of developing countries like ours. Objective: This study was done to evaluate the safety and efficacy of hypofractionated whole breast radiation therapy in patients who underwent breast conserving surgery and hypofractionated radiation therapy in patients who underwent mastectomy and axillary clearance. Materials and method: This cross sectional study was conducted in Delta Hospital Ltd, Dhaka, Bangladesh, including 50 postoperative patients, (12 patients in Breast Conservation Therapy group and 38 in Post Mastectomy Radiation Therapy group), with invasive ductal carcinoma of breast treated with this hypofractionated radiotherapy protocol during the last 1.5 year. The patients were treated with 3DCRT, LINAC, 6 MV photon and appropriate electron energy. Results: Minimal post treatment acute morbidity was observed. Forty seven patients (94%) had grade-I acute skin toxicity and only 3 patients (6%) developed grade-II acute skin toxicity. Conclusion: Hypofractionated radiotherapy is as safe and effective as conventional fractionated radiotherapy and superior in terms of convenience. DOI: http://dx.doi.org/10.3329/dmcj.v3i1.22232 Delta Med Col J. Jan 2015; 3(1): 04-08

Management of octogenarians with female breast cancer in a rural oncology program.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e16513-e16513
Author(s):  
Mir Asif Alikhan ◽  
Dianne L Limesand ◽  
Mark Schmelzel ◽  
Thomas McGlone ◽  
David Powers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Stage Iii ◽  
Adjuvant Radiation ◽  
Breast Cancer Patients ◽  
Co Morbidity ◽  
Her 2

e16513 Background: Despite the fact that chronological age alone does not determine tolerance to cancer treatment, there is a general perception that elderly cancer patients do not receive standard treatment. We sought to review breast cancer patients above 80 years in our practice. Methods: Retrospective analysis was performed ofall women with breast cancer over the age of 80 either at the time of diagnosis or at the time of relapse since July 2005 till July 2011. Results: There were total of 492 breast cancer patients seen during the study period, 207 below 65, 213 between 66-79 and 70 above 80. 59 women met the study criteria. The median age was 86 (81to 99 years). 47 had activities of independent living, 8 were in an assisted living facility and 4 in nursing homes. Median Charlson Co morbidity Index was 2 (0-5). Pathological types: DCIS 2, Invasive ductal carcinoma 50, invasive lobular carcinoma 6 and 1 had apocrine carcinoma. 50 had ER+, PR+ and Her-, 2 patients had triple negative disease and 4 Her+. 2 patients had stage 0, 22 stage I, 23 Stage II, 7 stage III and 5 stage IV. All patients stage 0-III had surgical management, 39 had breast conservative surgery with sentinel node biopsy and 15 had mastectomy. Out of 28 patients referred for adjuvant radiation therapy 17 received it. 49 patients received hormone treatment (39 aromatase inhibitors- AIs and 14 tamoxifen) Chemotherapy was offered but refused by two stage III patients. 2 Her + patients received and tolerated well trastuzumab based chemotherapy. After a median follow up of 48 months (8-120 months) there was 1 local recurrence, 1 distant relapse and 14 deaths ( 11 from other causes 3 from breast cancer). Conclusions: In ourpractice, a majority of octogenarians and nonagenarians live independently and have minimal co morbidities and tolerate standard surgical and hormonal treatment. Although radiation therapy would be considered optional in this group of women, it was offered based on predicted longevity. Mortality form other causes was higher than that from breast cancer ( 18% vs 5%).

Perceived stress to predict for acute radiation-induced skin toxicity: The mind-body connection.

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 62-62
Author(s):  
Bree Ruppert Eaton ◽  
Tian Liu ◽  
Xiaofeng Yang ◽  
Donna Mister ◽  
Yize Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Perceived Stress ◽  
Univariate Analysis ◽  
High Stress ◽  
Skin Toxicity ◽  
Skin Thickness ◽  
Breast Volume ◽  
Breast Cancer Patients ◽  
Acute Skin Toxicity

62 Background: Previous studies have reported that breast cancer patients with high stress levels at diagnosis develop more frequent and severe side effects of chemotherapy treatment. However, the relationship between stress and radiotherapy (RT) related treatment toxicity has not been evaluated. We investigated whether baseline stress is associated with worse acute skin toxicity in women undergoing breast RT. Methods: Between March 2010 and April 2013, 80 post-lumpectomy breast cancer patients were enrolled on a prospective study prior to undergoing definitive whole breast RT (50 Gy plus a 10 Gy boost). Prior to RT (baseline), at week 6 of RT (T2), and 6 weeks post RT (T3), subjects completed the Perceived Stress Scale (PSS) and underwent objective ultrasound measurements of epidermal thickness over the lumpectomy cavity and in all four quadrants of the treated breast. A skin thickness ratio (STRA) was generated by normalizing for measurements taken of the untreated breast. RT-induced skin toxicity was assessed by measuring the change in STRA from baseline to T2 and T3. Results: Mean STRA increased by 23% (SD 27%) and 33% (SD 25%) from baseline to T2 and T3, respectively. Univariate analysis revealed PSS score at baseline (p=.04), body mass index (p=.03), maximum RT dose (Dmax) (p=.02) and whole breast volume (p<.001) were significantly associated with increased changes in STRA during RT. Depression, fatigue, race, chemotherapy, patient age, and tumor stage were not associated with changes in STRA. On multivariate analysis, PSS (p=.05), breast volume (p=.004), and Caucasian race (p=.04) were associated with greater acute changes in STRA from baseline to T2. Breast volume (p=.01), but not PSS, predicted for greater changes in STRA 6 weeks after RT was completed. Conclusions: In women with breast cancer, a high level of perceived stress prior to RT is associated with more severe acute skin toxicity during RT but not after RT is completed. Strategies to reduce stress prior to RT may improve tolerance of treatment.

Common variants of eNOS and XRCC1 genes may predict acute skin toxicity in breast cancer patients receiving radiotherapy after breast conserving surgery

2012 ◽  
Vol 103 (2) ◽  
pp. 199-205 ◽  
Author(s):  
Salvatore Terrazzino ◽  
Pierdaniele La Mattina ◽  
Laura Masini ◽  
Tina Caltavuturo ◽  
Giuseppina Gambaro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Skin Toxicity ◽  
Breast Conserving Surgery ◽  
Common Variants ◽  
Breast Cancer Patients ◽  
Acute Skin Toxicity

Acute skin toxicity in Korean breast cancer patients carryingBRCAmutations

2013 ◽  
Vol 90 (1) ◽  
pp. 90-94 ◽  
Author(s):  
Hyojung Park ◽  
Doo Ho Choi ◽  
Jae Myoung Noh ◽  
Seung Jae Huh ◽  
Won Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Skin Toxicity ◽  
Breast Cancer Patients ◽  
Acute Skin Toxicity

scholarly journals EP-1187: T-lysyal based cream (Repalysyal) in the prevention of acute skin toxicity in breast cancer patients

2016 ◽  
Vol 119 ◽  
pp. S564-S565
Author(s):  
A. Rese ◽  
E. D'Ippolito ◽  
F. Piccolo ◽  
P. Romanelli ◽  
A. Romano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Skin Toxicity ◽  
Breast Cancer Patients ◽  
Acute Skin Toxicity

Impact of Patient Distance to Radiation Therapy on Mastectomy Use in Early-Stage Breast Cancer Patients

2005 ◽  
Vol 23 (28) ◽  
pp. 7074-7080 ◽  
Author(s):  
Anneke T. Schroen ◽  
David R. Brenin ◽  
Maria D. Kelly ◽  
William A. Knaus ◽  
Craig L. Slingluff
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Early Stage ◽  
Breast Conservation ◽  
Early Stage Breast Cancer ◽  
Rural Setting ◽  
Breast Cancer Patients ◽  
Treatment Access ◽  
New Facilities

Purpose Treatment access underlies quality cancer care. We hypothesize that mastectomy rates in a rural state are independently influenced by distance to radiation therapy (XRT) and by changing XRT access through opening new facilities. Patients and Methods Early-stage breast cancer patients diagnosed from 1996 to 2000 were identified in the Virginia state registry. Distance from patient zip code to nearest XRT facility was calculated with geographical software. Distance to XRT facility (≤ 10, > 10 to 25, > 25 to 50, and > 50 miles), American Joint Committee on Cancer tumor stage, age, race, and diagnosis year were evaluated for influencing mastectomy rate. Mastectomy use within 15 miles of five new facilities was assessed before and after opening. Results Among 20,094 patients, 43% underwent mastectomy, 53% underwent lumpectomy, and therapy of 4% of patients is unknown. Twenty-nine percent of patients lived more than 10 miles from XRT facility. Mastectomy increased with distance to XRT facility (43% at ≤ 10 miles, 47% at > 10 to 25 miles, 53% at > 25 to 50 miles, and 58% at > 50 miles; P < .001). Among 11,597 patients with T1 (< 2 cm) tumors, mastectomy also varied by distance (31% at ≤ 10 miles, 36% at > 10 to 25 miles, 41% at > 25 to 50 miles, and 49% at > 50 miles; P < .001). In multivariate analysis, mastectomy use was independently influenced by XRT distance after adjusting for age, race, T stage, and diagnosis year. Over the study period, mastectomy rates declined from 48% to 43% across Virginia, and there were similar declines in a 15-mile area around four new radiation facilities in urban settings. However, mastectomies decreased from 61% to 45% around a new XRT facility in a rural setting. Conclusion Distance to XRT facility significantly impacts mastectomy use. Opportunities for increasing breast-conservation rates through improved XRT access exist.

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