scholarly journals Formulation of fast disintegrating domperidone tablets using Plantago ovata mucilage by 32 full factorial design

2015 ◽  
Vol 4 (8) ◽  
pp. 415-419
Author(s):  
S. M. Shahidulla ◽  
Mohib Khan ◽  
K. N. Jayaveera
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Microcrystalline Cellulose ◽  
Tablet Formulation ◽  
Plantago Ovata ◽  
Short Term ◽  
Term Stability ◽  
Drug Content ◽  
Full Factorial

The present work was carried out to study the disintegrant property of plantago ovata mucilage. The objective of the work was to formulate Fast disintegrating tablets of Domperidon with a view to enhance patient compliances and dissolution rate by direct compression method using 3² full factorial design. Plantago ovata mucilage (2-10% w/w) was used as natural superdisintegrant and microcrystalline cellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 10s); the formulation containing 10% w/w Plantago ovata mucilage and 30%w/w microcrystalline cellulose was found to be promising and tested for in vitro drug release pattern (in 0.1 N HCl), short-term stability (at 40º/75% RH for 3 month) and drug-excipient interaction. Surface response plots are presented to graphically represent the effect of independent variables (concentrations of Plantago ovata mucilage and microcrystalline cellulose) on the in vitro dispersion time. The validity of the generated mathematical model was tested by preparing two extra-design check point formulations. The optimized tablet formulation was compared with conventional commercial tablet formulation for drug release profiles. This formulation showed nearly four-fold faster drug release (t50% 2.85 min) compared to the conventional commercial tablet formulation (t50% 7.85 min). Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).Shahidulla et al., International Current Pharmaceutical Journal, July 2015, 4(8): 415-419

scholarly journals Orodispersible Tablets of Carbamazepine Prepared by Direct Compression Method Using 32 Full Factorial Design

1970 ◽  
Vol 7 (1) ◽  
pp. 1-5
Author(s):  
PV Swamy ◽  
SM Shahidulla ◽  
SB Shirsand ◽  
SN Hiremath ◽  
Md Younus Ali
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Direct Compression ◽  
Compression Method ◽  
Short Term ◽  
Term Stability ◽  
Drug Content ◽  
Orodispersible Tablets ◽  
Full Factorial

Orodispersible tablets of carbamazepine were prepared with a view to enhance patient compliance by direct compression method using 3² full factorial design. Crospovidone (2-10% w/w) was used as superdisintegrant and microcrystallinecellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 10 s); the formulation containing 2% w/w crospovidone and 30%w/w microcrystallinecellulose was found to be promising and tested for in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40º/75 % RH for 3 w) and drug-excipient interaction. This formulation showed four-fold faster drug release (t25%) compared to the conventional commercial tablet formulation. Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).Key words: Orodispersible tablets, carbamazepine, crospovidone, micro crystallinecellulose, 3² full factorial designDOI = 10.3329/dujps.v7i1.1199Dhaka Univ. J. Pharm. Sci. 7(1): 1-5, 2008 (June)

scholarly journals FORMULATION AND EVALUATION OF FAMOTIDINE FAST DISSOLVING TABLETS USING SYNTHETIC SUPERDISINTEGRANTS

2019 ◽  
pp. 17-25
Author(s):  
SARIPILLI RAJESWARI ◽  
M. YERNI KUMARI
Keyword(s):  
Drug Release ◽  
Microcrystalline Cellulose ◽  
Research Work ◽  
Content Uniformity ◽  
Short Term ◽  
In Vitro Drug Release ◽  
Term Stability ◽  
Drug Content ◽  
Release Studies

Objective: The main aim of the present research work was to formulate fast dissolving tablets of famotidine by direct compression method and to evaluate the effect of synthetic super disintegrating agent on drug release pattern. Methods: The fast dissolving tablets were prepared by using crospovidone, croscarmellose sodium, sodium starch glycolate as superdisintegrants (2, 4 and 6 %w/w), mannitol 20 % and microcrystalline cellulose (44, 46 and 48 % w/w) as a directly compressible vehicle. All the prepared tablets were evaluated for hardness, friability, drug content uniformity, weight variation, disintegrating time, wetting time and in vitro drug release studies. Results: All the prepared fast dissolving tablets formulations were within the Pharmacopoeial standards limits. Based on in vitro drug release studies (>90 % within 30 min), the optimised formulations were optimised tested for the short term stability (at 40 ˚C/75% RH for 3 mo) and drug excipient interaction (fourier transform infrared spectroscopy). Conclusion: Hence, formulation prepared with 6 % w/w of crosspovidine and 44 % w/w of microcrystalline cellulose as emerged as the overall best formulation (>90 % within 30 min) compared to marketed product (>70 % within 30 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro drug release (p<0.05).

scholarly journals The Effect of Cast Films of Bovine Mucin and Prosopis Gum Containing a Cicatrin® Powder on Wound Healing

1970 ◽  
Vol 7 (1) ◽  
pp. 7-10 ◽  
Author(s):  
MA Momoh ◽  
MU Adikwu ◽  
SO Eraga
Keyword(s):  
Drug Release ◽  
Content Uniformity ◽  
Short Term ◽  
In Vitro Drug Release ◽  
Term Stability ◽  
Drug Content ◽  
Wetting Time ◽  
Mouth Feel ◽  
Full Factorial

Orodispersible tablets of carbamazepine were prepared with a view to enhance patient compliance by direct compression method using 3² full factorial design. Crospovidone (2-10% w/w) was used as superdisintegrant and microcrystallinecellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 10 s); the formulation containing 2% w/w crospovidone and 30%w/w microcrystallinecellulose was found to be promising and tested for in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40º/75 % RH for 3 w) and drug-excipient interaction. This formulation showed four-fold faster drug release (t25%) compared to the conventional commercial tablet formulation. Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).  Key words: mucin, Prosopis gum, cicatrin, healingDOI = 10.3329/dujps.v7i1.1200Dhaka Univ. J. Pharm. Sci. 7(1): 7-10, 2008 (June)

DESIGN AND EVALUATION OF DOMPERIDONE FAST DISINTEGRATING TABLETS BY WET GRANULATION TECHNIQUES USING PLANTAGO OVATA MUCILAGE

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (06) ◽  
pp. 49-54
Author(s):  
S M Shahidulla ◽  
◽  
Mohib Khan ◽  
K N Jayaveera
Keyword(s):  
Wet Granulation ◽  
Content Uniformity ◽  
Plantago Ovata ◽  
Short Term ◽  
Granulation Process ◽  
Term Stability ◽  
Drug Content ◽  
Starch Paste ◽  
Fast Disintegrating Tablets

In the present study, fast disintegrating tablets of domperidone were prepared to enhance patient compliance by wet granulation method. In the study, fast disintegrating tablets of the drug using, Plantago ovata mucilage and Crospovidone were used as superdisintegrants (2.5 to 10 % w/w) along with starch paste as a binder. The disintegrant was incorporated during the wet granulation process as an extra granular incorporation. The prepared tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (approximately 12 s), the two formulations were tested for in vitro drug release, short term stability (at 40o /75 % RH for 3 months) and drug excipient interaction (IR spectroscopy). Among the two promising formulations, the formulations prepared by using 10% w/w of Plantago ovata mucilage and 32% w/w of starch paste emerged as the overall best formulation (t50 % 2.90 min) compared to conventional commercial tablets formulations (t50% 7.85 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p<0.05).

DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES OF NICERGOLINE FOR BUCCAL DRUG DELIVERY BY USING FACTORIAL DESIGN OF EXPERIMENT (DOE)

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (07) ◽  
pp. 52-57
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Design Of Experiment ◽  
Release Profile ◽  
Drug Release Profile ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Drug Content ◽  
Release Study

The aim of this research was to develop mucoadhesive buccal patches of nicergoline by using Factorial Design of Experiment, in order to provide a sustained release of drug into the systemic circulation. A 33 factorial experimental design was employed for optimization and to study the effect of formulation variables on responses R1 (% swelling index), R2 (% drug content), R3 (mucoadhesion time) and R4 (mucoadhesion strength). In vitro drug release study was performed on the optimized formulations. All the prepared formulations had good mechanical strength, mucoadhesion strength, neutral surface pH and drug content up to 98.17%. In vitro drug release study revealed that F-5 formulation showed promising sustained drug release profile (98.21%) for over 8 h and could be a potential substitute for marketed conventional formulations. The developed formulation (F5) was found to be optimized with considerably good stability and extended drug release profile.

scholarly journals IMPLEMENTATION OF QUALITY BY DESIGN (QBD) APPROACH IN FORMULATION AND DEVELOPMENT OF RITONAVIR PELLETS USING EXTRUSION SPHERONIZATION METHOD

2019 ◽  
pp. 139-146
Author(s):  
SATISH K. MANDLIK ◽  
PAYAL P. AGARWAL ◽  
HARSHAL P. DANDGAVHAL
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Factorial Design ◽  
Quality By Design ◽  
Research Work ◽  
Full Factorial Design ◽  
Extrusion Speed ◽  
Full Factorial ◽  
Extrusion Spheronization

Objective: Ritonavir is an antiretroviral drug used for HIV-AIDS treatment. The purpose of this research work was to implement the quality by design (QbD) approach in formulation of ritonavir sustained-release pellets by industrially applied extrusion spheronization technique. Methods: Pellets were prepared by extrusion spheronization method and evaluated for their physicochemical properties. Initially, on the basis of prior knowledge Quality Target Product Profile (QTTP) element was identified and further Critical Quality Attributes (CQA) elements were defined. Risk assessment (RA) was done by two tools as failure mode and effect analysis (FMEA) and fishbone diagram (Ishikawa plot). Placket Burman design was implemented as a screening design using seven high-risk factors (spheronization speed, spheronization time, extrusion speed, drying method, PVP K 30, cross povidone, and solvent). Optimization study was done by 23 full factorial design with three critical factors as (spheronization speed, extrusion speed and PVP K 30). The in vitro drug release was studied in both gastric and intestinal fluids for 12 h using USP Ι apparatus. Control space was established for the sustained release pellets. Results: Among all batches obtained in 23 full factorial design, batch R7 was found to be effective with carr’s index value of 5.281, percentage yield of 69.6%, time required to release 50% drug was 8 h and percent drug release after 12 h was found 83.132 %, R7 batch was selected as optimized batch. Statistical analysis showed model terms were significant. Conclusion: We can conclude that; sustained-release pellets of ritonavir were successfully designed using QbD approach.

scholarly journals Enhancement of Solubility of Lamotrigine by Solid Dispersion and Development of Orally Disintegrating Tablets Using 32 Full Factorial Design

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Jatinderpal Singh ◽  
Rajeev Garg ◽  
Ghanshyam Das Gupta
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Solid Dispersion ◽  
Disintegration Time ◽  
Drug Release Study ◽  
Orally Disintegrating Tablets ◽  
Wetting Time ◽  
Release Study ◽  
Full Factorial

Present investigation deals with the preparation and evaluation of orally disintegrating tablets (ODTs) of lamotrigine using β-cyclodextrin and PVP-K30 as polymers for the preparation of solid dispersion which help in enhancement of aqueous solubility of this BCS CLASS-II drug and sodium starch glycolate (SSG) and crospovidone as a superdisintegrating agent, to reduce disintegration time. The ODTs were prepared by direct compression method. Nine formulations were developed with different ratios of superdisintegrating agents. All the formulations were evaluated for disintegration time, weight variation, hardness, friability, drug content uniformity, wetting time, and in vitro drug release study. In vitro drug release study was performed using United States Pharmacopoeia (USP) type 2 dissolution test apparatus employing paddle stirrer at 50 rpm using 900 mL of 0.1 N HCl maintained at 37°C ± 0.5°C as the dissolution medium. On the basis of evaluation parameters formulations were prepared using β-CD 1 : 1 solid dispersion. Then 32 full factorial design was applied using SSG and crospovidone in different ratios suggested by using design expert 8.0.7.1 and optimized formulation was prepared using amount of SSG and crospovidone as suggested by the software. The optimized formulation prepared had disintegrating time of 15 s, wetting time of 24 s, and % friability of 0.55.

scholarly journals DESIGN, DEVELOPMENT & CHARACTERIZATION OF FAST DISSOLVING TABLET OF CARVEDILOL

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Ankit Sharma ◽  
Mayank Bansal
Keyword(s):  
Drug Release ◽  
Solid Dispersion ◽  
Microcrystalline Cellulose ◽  
Research Work ◽  
Magnesium Stearate ◽  
Design Development ◽  
Drug Content ◽  
Rapid Release ◽  
Blocking Activity

Fast dissolving tablets are developed as an alternative to tablet, capsule and syrup for the paediatric and geriatric patient suffering from disease who feels difficulty in swallowing the oral solid dosage form. Carvedilol is practically insoluble in water, slightly soluble in an alcohol, practically insoluble in dilute acids. Carvedilol is a non-cardioselective beta blocker. It has vasodilating properties, which are attributed mainly to its blocking activity at alpha1 receptors; at higher doses calcium-channel blocking activity may contribute. Carvedilol competitively blocks receptors. The elimination half-life is about 6 to 10 hours. The main objective of this research work was to formulate and evaluate fast dissolving tablet of carvedilol using excipients like Croscarmellose sodium, Crospovidone, Microcrystalline Cellulose,   magnesium stearate, PVP etc.  Formulation of fast dissolving tablets of Carvedilol by direct compression method using different types of polymer in different percentages. The tablets with drug were also evaluated for uniformity of drug content, in-vitro drug release and stability studies. The drug content in the fast dissolving tablets was found to be uniform and with low correlation of variation. The tablets prepared with solid dispersion in combination with super disintegrate showed better release profile as compared to only incorporation of super disintegrates.  The tablets prepared by effervescent and pore forming technology provides satisfactory drug release. The release of drug followed first order kinetics and mechanism of drug release was found to be diffusion controlled. The stability data at different temperature and humidity showed no significant degradation of Carvedilol and shelf life found to be more than 520 days. Fast dissolving tablets prepared by the Ac – Di – Sol in 4% concentration are promising for rapid release of Carvedilol.  Incorporation of solid dispersion (PEG 4000 : CARVEDILOL) (4:1)  into Ac – Di – Sol in 2 % concentration enhanced the release rate of Carvedilol and thus therapeutic levels of the drug could be achieved through fast dissolving tablets. Tablets prepared by effervescent and pore forming technologies are also very promising for stable and rapid release of Carvedilol. Keywords: Carvedilol, FDDS, solid dispersion, tablets, Sodium, Crospovidone, Microcrystalline Cellulose,   magnesium stearate, PVP.

Formulation and Evaluation of Mucoadhesive Buccal Tablets of Anti-Diabetic Drug using 23 Factorial Design

2021 ◽  
pp. 261-266
Author(s):  
P. Nagaveni ◽  
Sirisha. S ◽  
C. Appa Rao
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Xanthan Gum ◽  
Ex Vivo ◽  
Research Work ◽  
Content Uniformity ◽  
Weight Variation ◽  
Buccal Tablets ◽  
Full Factorial

The aim of the present study involved the formulation and evaluation of mucoadhesive buccal tablets of anti-diabetic drug gliclazide, Mucoadhesive buccal tablets of Gliclazide are prepared by direct compression method In this present investigational research work the mucoadhesive buccal tablets of gliclazide is prepared separately employing 23 randomized full factorial design by using xanthan gum, carbopol-934, HPMC-E15LV, In this experimental model, target is to determine how the t90% of drug release and mucoadhesive characters can be affected by adjusting three parameters, concentration of polymers xanthan gum, HPMC-E15LV, carbopol-934, of the mucoadhesive buccal tablets. 2 3 full factorial studies were designed to determine the interaction of three independent variables at two levels (low and high level concentration) The tablets were tested for weight variation, hardness, surface pH, drug content uniformity, swelling index, mucoadhesion strength and in-vitro drug release study, Ex- vivo mucoadhesion time. From the drug release studies it was found that formulation H4 containing has good drug release when compared to other formulations.

Design and In vivo Evaluation of Palonosetron HCl Mouth Dissolving Films in the Management of Chemotherapy-Induced Vomiting

2017 ◽  
Vol 10 (6) ◽  
pp. 3929-3936
Author(s):  
Y. Srinivasa Rao ◽  
K. Adinarayana Reddy
Keyword(s):  
Drug Release ◽  
Patient Compliance ◽  
Onset Of Action ◽  
In Vivo Evaluation ◽  
Disintegration Time ◽  
In Vitro Drug Release ◽  
Surface Ph ◽  
Drug Content

Fast dissolving oral delivery systems are solid dosage forms, which disintegrate or dissolve within 1 minute in the mouth without drinking water or chewing. Mouth dissolving film (MDF) is a better alternate to oral disintegrating tablets due to its novelty, ease of use and the consequent patient compliance. The purpose of this work was to develop mouth dissolving oral films of palonosetron HCl, an antiemetic drug especially used in the prevention and treatment of chemotherapy-induced nausea and vomiting. In the present work, the films were prepared by using solvent casting method with various polymers HPMC E3, E5 & E15 as a film base synthetic polymer, propylene glycol as a plasticizer and maltodextrin and other polymers. Films were found to be satisfactory when evaluated for thickness, in vitro drug release, folding endurance, drug content and disintegration time. The surface pH of all the films was found to be neutral. The in vitro drug release of optimized formulation F29 was found to be 99.55 ± 6.3 7% in 7 min. The optimized formulation F29 also showed satisfactory surface pH, drug content (99.38 ± 0.08 %), disintegration time of 8 seconds and good stability. FTIR data revealed that no interaction takes place between the drug and polymers used in the optimized formulation. In vitro and in vivo evaluation of the films confirmed their potential as an innovative dosage form to improve delivery and quick onset of action of Palonosetron Hydrochloride. Therefore, the mouth dissolving film of palonosetron is potentially useful for the treatment of emesis disease where quick onset of action is desired, also improved patient compliance.

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