scholarly journals FORMULATION AND EVALUATION OF FAMOTIDINE FAST DISSOLVING TABLETS USING SYNTHETIC SUPERDISINTEGRANTS

2019 ◽  
pp. 17-25
Author(s):  
SARIPILLI RAJESWARI ◽  
M. YERNI KUMARI
Keyword(s):  
Drug Release ◽  
Microcrystalline Cellulose ◽  
Research Work ◽  
Content Uniformity ◽  
Short Term ◽  
In Vitro Drug Release ◽  
Term Stability ◽  
Drug Content ◽  
Release Studies

Objective: The main aim of the present research work was to formulate fast dissolving tablets of famotidine by direct compression method and to evaluate the effect of synthetic super disintegrating agent on drug release pattern. Methods: The fast dissolving tablets were prepared by using crospovidone, croscarmellose sodium, sodium starch glycolate as superdisintegrants (2, 4 and 6 %w/w), mannitol 20 % and microcrystalline cellulose (44, 46 and 48 % w/w) as a directly compressible vehicle. All the prepared tablets were evaluated for hardness, friability, drug content uniformity, weight variation, disintegrating time, wetting time and in vitro drug release studies. Results: All the prepared fast dissolving tablets formulations were within the Pharmacopoeial standards limits. Based on in vitro drug release studies (>90 % within 30 min), the optimised formulations were optimised tested for the short term stability (at 40 ˚C/75% RH for 3 mo) and drug excipient interaction (fourier transform infrared spectroscopy). Conclusion: Hence, formulation prepared with 6 % w/w of crosspovidine and 44 % w/w of microcrystalline cellulose as emerged as the overall best formulation (>90 % within 30 min) compared to marketed product (>70 % within 30 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro drug release (p<0.05).

scholarly journals The Effect of Cast Films of Bovine Mucin and Prosopis Gum Containing a Cicatrin® Powder on Wound Healing

1970 ◽  
Vol 7 (1) ◽  
pp. 7-10 ◽  
Author(s):  
MA Momoh ◽  
MU Adikwu ◽  
SO Eraga
Keyword(s):  
Drug Release ◽  
Content Uniformity ◽  
Short Term ◽  
In Vitro Drug Release ◽  
Term Stability ◽  
Drug Content ◽  
Wetting Time ◽  
Mouth Feel ◽  
Full Factorial

Orodispersible tablets of carbamazepine were prepared with a view to enhance patient compliance by direct compression method using 3² full factorial design. Crospovidone (2-10% w/w) was used as superdisintegrant and microcrystallinecellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 10 s); the formulation containing 2% w/w crospovidone and 30%w/w microcrystallinecellulose was found to be promising and tested for in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40º/75 % RH for 3 w) and drug-excipient interaction. This formulation showed four-fold faster drug release (t25%) compared to the conventional commercial tablet formulation. Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).  Key words: mucin, Prosopis gum, cicatrin, healingDOI = 10.3329/dujps.v7i1.1200Dhaka Univ. J. Pharm. Sci. 7(1): 7-10, 2008 (June)

scholarly journals Formulation of fast disintegrating domperidone tablets using Plantago ovata mucilage by 32 full factorial design

2015 ◽  
Vol 4 (8) ◽  
pp. 415-419
Author(s):  
S. M. Shahidulla ◽  
Mohib Khan ◽  
K. N. Jayaveera
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Microcrystalline Cellulose ◽  
Tablet Formulation ◽  
Plantago Ovata ◽  
Short Term ◽  
Term Stability ◽  
Drug Content ◽  
Full Factorial

The present work was carried out to study the disintegrant property of plantago ovata mucilage. The objective of the work was to formulate Fast disintegrating tablets of Domperidon with a view to enhance patient compliances and dissolution rate by direct compression method using 3² full factorial design. Plantago ovata mucilage (2-10% w/w) was used as natural superdisintegrant and microcrystalline cellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 10s); the formulation containing 10% w/w Plantago ovata mucilage and 30%w/w microcrystalline cellulose was found to be promising and tested for in vitro drug release pattern (in 0.1 N HCl), short-term stability (at 40º/75% RH for 3 month) and drug-excipient interaction. Surface response plots are presented to graphically represent the effect of independent variables (concentrations of Plantago ovata mucilage and microcrystalline cellulose) on the in vitro dispersion time. The validity of the generated mathematical model was tested by preparing two extra-design check point formulations. The optimized tablet formulation was compared with conventional commercial tablet formulation for drug release profiles. This formulation showed nearly four-fold faster drug release (t50% 2.85 min) compared to the conventional commercial tablet formulation (t50% 7.85 min). Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).Shahidulla et al., International Current Pharmaceutical Journal, July 2015, 4(8): 415-419

scholarly journals Formulation and characterization of a novel pH-triggered in-situ gelling ocular system containing Gatifloxacin

1970 ◽  
Vol 1 (3) ◽  
pp. 43-49 ◽  
Author(s):  
Jovita Kanoujia ◽  
Kanchan Sonker ◽  
Manisha Pandey ◽  
Koshy M Kymonil ◽  
Shubhini A Saraf
Keyword(s):  
Drug Release ◽  
Research Work ◽  
Gelling Agent ◽  
In Vitro Drug Release ◽  
Drug Content ◽  
Carbopol 940 ◽  
In Situ Gelling ◽  
Gel Transition

The present research work deals with the formulation and evaluation of in-situ gelling system based on sol-to-gel transition for ophthalmic delivery of an antibacterial agent gatifloxacin, to overcome the problems of poor bioavailability and therapeutic response exhibited by conventional formulations based a sol-to-gel transition in the cul-de-sac upon instillation. Carbopol 940 was used as the gelling agent in combination with HPMC and HPMC K15M which acted as a viscosity enhancing agent. The prepared formulations were evaluated for pH, clarity, drug content, gelling capacity, bioadhesive strength and in-vitro drug release. In-vitro drug release data of optimized formulation (F12) was treated according to Zero, First, Korsmeyer Peppas and Higuchi kinetics to access the mechanism of drug release. The clarity, pH, viscosity and drug content of the developed formulations were found in range 6.0-6.8, 10-570cps, 82-98% respectively. The gel provided sustained drug release over an 8 hour period. The developed formulation can be used as an in-situ gelling vehicle to enhance ocular bioavailability and the reduction in the frequency of instillation thereby resulting in better patient compliance. Key Words: In-situ gelation; Gatifloxacin; Carbopol 940; HPMC K15M. DOI: http://dx.doi.org/10.3329/icpj.v1i3.9661 International Current Pharmaceutical Journal 2012, 1(3): 43-49

DESIGN AND EVALUATION OF DOMPERIDONE FAST DISINTEGRATING TABLETS BY WET GRANULATION TECHNIQUES USING PLANTAGO OVATA MUCILAGE

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (06) ◽  
pp. 49-54
Author(s):  
S M Shahidulla ◽  
◽  
Mohib Khan ◽  
K N Jayaveera
Keyword(s):  
Wet Granulation ◽  
Content Uniformity ◽  
Plantago Ovata ◽  
Short Term ◽  
Granulation Process ◽  
Term Stability ◽  
Drug Content ◽  
Starch Paste ◽  
Fast Disintegrating Tablets

In the present study, fast disintegrating tablets of domperidone were prepared to enhance patient compliance by wet granulation method. In the study, fast disintegrating tablets of the drug using, Plantago ovata mucilage and Crospovidone were used as superdisintegrants (2.5 to 10 % w/w) along with starch paste as a binder. The disintegrant was incorporated during the wet granulation process as an extra granular incorporation. The prepared tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (approximately 12 s), the two formulations were tested for in vitro drug release, short term stability (at 40o /75 % RH for 3 months) and drug excipient interaction (IR spectroscopy). Among the two promising formulations, the formulations prepared by using 10% w/w of Plantago ovata mucilage and 32% w/w of starch paste emerged as the overall best formulation (t50 % 2.90 min) compared to conventional commercial tablets formulations (t50% 7.85 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p<0.05).

Preparation and Characterization of Gastroretentive Floating Microspheres of Ofloxacin Hydrochloride

2010 ◽  
Vol 3 (1) ◽  
pp. 819-823
Author(s):  
Mona Semalty ◽  
Shikha Yadav ◽  
Ajay Semalty
Keyword(s):  
Gastrointestinal Tract ◽  
Drug Release ◽  
Poly Vinyl Alcohol ◽  
Content Uniformity ◽  
In Vitro Drug Release ◽  
Therapeutic Uses ◽  
Diffusion Technique ◽  
Release Studies

As Ofloxacin is preferably absorbed from the upper part of the gastrointestinal tract and is readily soluble in the acidic environment of the stomach, the floating microspheres of ofloxacin were formulated to develop gastroretentive formulation. These floating microspheres release the drug in the stomach and upper gastrointestinal tract and thereby improve the bioavailability. In the present study, six formulations of ofloxacin hydrochloride were prepared as floating microspheres by solvent diffusion technique using polymers such as ethyl cellulose, polyvinyl pyrrolidone K-90 and poly vinyl alcohol in different ratios. The prepared microspheres were evaluated for different physicochemical tests such as particle size, percent drug entrapment, drug content uniformity, SEM, buoyancy test, and in vitro drug release studies. The results of all the physicochemical tests of all formulations were found to be satisfactory. In vitro floatability studies revealed that most of the microspheres (52.5% to 95.5%) were floatable. The in vitro drug release was found to be in the range of 39.64 to 93.64 % at the end of 6 hours. It is concluded that these floating microspheres can be selected for the development of gastroretentive drug delivery system of ofloxacin hydrochloride for potential therapeutic uses.

Biodegradable Amphiphilic Tri-Block Copolymeric Nanoparticles for Controlled MTB Drug Delivery

2012 ◽  
Vol 584 ◽  
pp. 460-464 ◽  
Author(s):  
M Gajendiran ◽  
S. Balasubramanian
Keyword(s):  
Drug Release ◽  
Drug Loading ◽  
Powder Xrd ◽  
Burst Release ◽  
In Vitro Drug Release ◽  
Drug Content ◽  
Loading Efficiency ◽  
Release Studies ◽  
Drug Loading Efficiency

. A series of biodegradable amphiphilic tri-block copolymers (PLGA–PEG–PLGA) have been derived from the diblock copolymer poly (lactic–co–glycolic acid (PLGA)) and polyethylene glycol (PEG). The mycobacterium tuberculosis (MTB) drug pyrazinamide (PZA) loaded polymer nanoparticles (NPs) have been prepared by probe-sonication followed by w/o/w double emulsification technique. The copolymers have been characterized by FTIR and 1HNMR spectroscopic techniques, TG-DTA analysis, GPC analysis and powder XRD pattern. The MTB drug loaded polymeric NPs have been characterized by FESEM, powder XRD, HRTEM and XPS analysis. The drug loading efficiency, drug content and in vitro drug release studies have been carried out by spectrophotometry. The drug loading efficiency and drug content of triblock copolymeric NPs were higher than these of diblock copolymeric microparticles (MPs). The in vitro drug release studies indicate that the NPs exhibit initial burst release followed by controlled release of PZA for longer durations. The drug release kinetics mechanism has been evaluated by zero order, first order, Korsemeyer-Peppas (KP) and Higuchi models.

scholarly journals Hibiscus sabdariffa Mucilage as a Disintegrant in Formulating Fast Dissolving Tablets

2017 ◽  
Vol 15 (2) ◽  
pp. 143-149
Author(s):  
SB Shirsand ◽  
Shivanand ◽  
Shailashri ◽  
GG Keshavshetti ◽  
V Jonathan
Keyword(s):  
Drug Release ◽  
Hibiscus Sabdariffa ◽  
Compression Method ◽  
In Vitro Drug Release ◽  
Basella Alba ◽  
Drug Content ◽  
Release Studies ◽  
Wetting Time ◽  
Mouth Feel

The aim of the present work was to prepare and evaluate fast dissolving tablets of nebivolol with a view to enhance patient compliance and minimize the side effects. In this study, fast dissolving tablets of nebivolol were formulated by direct compression method using mucilages of tapioca seeds (Manihot esculenta), basella climb (Basella alba), red sorrel (Hibiscus sabdariffa) as natural disintegrants and crosspovidone as a synthetic superdisintegrant in different ratios with directly compressible mannitol (Pearlitol SD 200) as a diluent to enhance the mouth feel. The prepared formulations were evaluated for hardness, friability, drug content, in vitro dispersion time, wetting time, water absorption ratio, in vitro drug release, stability and excipients interaction. Among all the formulations, the formulation (FHD3) containing 8% w/w mucilage of Hibiscus sabdariffa was the overall best formulation (t50% 1.7 min) based on in vitro drug release studies. Stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p<0.05). From the above studies, it can be concluded that fast dissolving tablets of nebivolol can be prepared using different mucilages as natural disintegrants for faster dispersion and disintegration in the mouth.Dhaka Univ. J. Pharm. Sci. 15(2): 143-149, 2016 (December)

scholarly journals FORMULATION DESIGN AND CHARACTERIZATION OF ROPINIROLE HYDROCHORIDE MICROSPHERE FOR INTRANASAL DELIVERY

2017 ◽  
Vol 10 (7) ◽  
pp. 195
Author(s):  
Shubhrajit Mantry ◽  
Anna Balaji
Keyword(s):  
Drug Release ◽  
Guar Gum ◽  
Liquid Paraffin ◽  
Research Work ◽  
Physicochemical Characterization ◽  
In Vitro Drug Release ◽  
Nasal Irritation ◽  
Release Studies

Objective: The objective of this research work to design nasal microspheres of ropinirole hydrochloride (HCL) using different mucoadhesive polymers by adopting the suitable technique. To study the influence of formulation and process variables on microsphere formation and release characteristics. To perform the physicochemical characterization of the prepared microspheres. To carry out in vitro drug release studies and to explore the release behavior using various kinetic models.Methods: Experiments were performed with ropinirole HCL as a drug, chitosan, guar gum, carbopol 974P as a polymer. Span 80 and Tween 80 used light liquid paraffin, concentrated hydrochloric acid as solvent.Result: The in vitro drug release studies were conducted for all the formulations, that is, F1-F21 in 250 ml phosphate buffer pH 6.6 for 12 hrs. Among them, F15 showed 82.7±0.23% drug release and F21 showed 81.2% in 12 hrs in a sustained manner.Conclusion: Microspheres were formulated by emulsion solvent evaporation technique using different polymers. Apart from preventing nasal irritation, the microsphere possesses two major advantages over plain solutions, one is a high solubilization capacity for ropinirole HCL that exceeds their aqueous solubility and thus allows a reduction in the application volume. The results of this work indicate that intranasal microsphere of ropinirole may be beneficial for the treatment of Parkinson’s disease.

scholarly journals DESIGN, DEVELOPMENT, AND CHARACTERIZATION OF TOPICAL GEL CONTAINING ITRACONAZOLE - ANTIFUNGAL AGENT

2018 ◽  
Vol 11 ◽  
Author(s):  
Pavithra K
Keyword(s):  
Drug Release ◽  
Fungal Infections ◽  
Gelling Agent ◽  
Compatibility Study ◽  
In Vitro Drug Release ◽  
Topical Gel ◽  
Drug Content ◽  
Release Studies ◽  
Ft Ir

Objective: The main purpose of this study was to develop a topical delivery of itraconazole to reduce the dose of the drug, to improve patient compliance, and to avoid the side effects. Itraconazole is a triazole derivative to treat antifungal and antiprotozoal infections. Methods: Topical gel formulations of itraconazole were prepared using Carbopol 940 as a gelling agent with different concentrations. Four different formulations were prepared and evaluated with respect to color, spreadability, viscosity measurement, determination of pH, drug content, in vitro drug release studies, zeta potential studies, and stability studies. Compatibility study was carried out by Fourier-transform infrared (FT-IR) spectral analysis. Results: FT-IR study revealed that there were no significant interaction between the drug and polymers. All the prepared formulations show acceptable physical properties. The drug content and percentage yield were higher for F1 formulation among all formulation F1 shows better drug release. Stability study of best formulation shows that there was no difference in drug content and in vitro drug release studies. Conclusion: From the above observation results that this formulation may be more encouraging topical substitute for the healing of fungal infections in the skin.

scholarly journals DESIGN, DEVELOPMENT & CHARACTERIZATION OF FAST DISSOLVING TABLET OF CARVEDILOL

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Ankit Sharma ◽  
Mayank Bansal
Keyword(s):  
Drug Release ◽  
Solid Dispersion ◽  
Microcrystalline Cellulose ◽  
Research Work ◽  
Magnesium Stearate ◽  
Design Development ◽  
Drug Content ◽  
Rapid Release ◽  
Blocking Activity

Fast dissolving tablets are developed as an alternative to tablet, capsule and syrup for the paediatric and geriatric patient suffering from disease who feels difficulty in swallowing the oral solid dosage form. Carvedilol is practically insoluble in water, slightly soluble in an alcohol, practically insoluble in dilute acids. Carvedilol is a non-cardioselective beta blocker. It has vasodilating properties, which are attributed mainly to its blocking activity at alpha1 receptors; at higher doses calcium-channel blocking activity may contribute. Carvedilol competitively blocks receptors. The elimination half-life is about 6 to 10 hours. The main objective of this research work was to formulate and evaluate fast dissolving tablet of carvedilol using excipients like Croscarmellose sodium, Crospovidone, Microcrystalline Cellulose,   magnesium stearate, PVP etc.  Formulation of fast dissolving tablets of Carvedilol by direct compression method using different types of polymer in different percentages. The tablets with drug were also evaluated for uniformity of drug content, in-vitro drug release and stability studies. The drug content in the fast dissolving tablets was found to be uniform and with low correlation of variation. The tablets prepared with solid dispersion in combination with super disintegrate showed better release profile as compared to only incorporation of super disintegrates.  The tablets prepared by effervescent and pore forming technology provides satisfactory drug release. The release of drug followed first order kinetics and mechanism of drug release was found to be diffusion controlled. The stability data at different temperature and humidity showed no significant degradation of Carvedilol and shelf life found to be more than 520 days. Fast dissolving tablets prepared by the Ac – Di – Sol in 4% concentration are promising for rapid release of Carvedilol.  Incorporation of solid dispersion (PEG 4000 : CARVEDILOL) (4:1)  into Ac – Di – Sol in 2 % concentration enhanced the release rate of Carvedilol and thus therapeutic levels of the drug could be achieved through fast dissolving tablets. Tablets prepared by effervescent and pore forming technologies are also very promising for stable and rapid release of Carvedilol. Keywords: Carvedilol, FDDS, solid dispersion, tablets, Sodium, Crospovidone, Microcrystalline Cellulose,   magnesium stearate, PVP.

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