scholarly journals A Chronopharmacological Study Related to Doxorubicin Based Bone Marrow Suppression

2014 ◽  
Vol 2 (5) ◽  
pp. 197-201
Author(s):  
Vijayalakshmi Subbiah ◽  
K Rajendran ◽  
M Shanthi ◽  
R Parameswari
Keyword(s):  
Bone Marrow ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Bone Marrow Suppression ◽  
Care Hospital ◽  
Therapy Regimen ◽  
Circadian Time ◽  
Standard Doxorubicin ◽  
Time Cycle ◽  
Time Basis

Myelosuppression is the most common toxicity of anti-neoplastic therapy due to inhibition of cell replication in bone marrow. This can be minimized by administering drugs on the basis of circadian time basis. Hence the aim is to study circadian time cycle related bone marrow suppression variation resulting from doxorubicin based cancer chemo therapy regimen. A prospective observational clinical study based on circadian time Cycle was done for a period of six months at a tertiary care hospital. Standard doxorubicin Regimen was given in the dose of 60 mg/m as iv infusion. Each cycle is repeated every 21 Days. Complete hemogram was done on day 0 and day 10 of both day and night cycle. Results were analyzed using students paired t test. It was found that during Night cycle therapy bone marrow suppression was minimal and statistically significant (p<0.001). Chronotherapy is useful in minimizing bone marrow toxicity.DOI: http://dx.doi.org/10.3329/ijpls.v2i5.17627 International Journal of Pharmaceutical and Life Sciences, Volume 2(5) Dec 2013: 197-201

scholarly journals Role of Immunohistochemistry in trephine biopsies of Bone Marrow: A 5-year Retrospective study from a tertiary care hospital

2017 ◽  
Vol 4 (6) ◽  
pp. A727-A731
Author(s):  
Ravi Teja J ◽  
FebeRenjitha Suman ◽  
Lenna Dennis Joseph ◽  
JerushaSamuela Jacob ◽  
Rithika Rajendran ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Retrospective Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

scholarly journals BONE MARROW EVALUATION IN PATIENTS WITH PANCYTOPENIA- A CLINICO-HAEMATOLOGICAL STUDY IN A TERTIARY CARE HOSPITAL IN NORTH INDIA

2019 ◽  
Vol 8 (29) ◽  
pp. 2311-2315
Author(s):  
Neetu Purwar ◽  
Anita Omhare ◽  
Mahendra Singh ◽  
Dev Prakash Shivhare ◽  
Brijendra Nath Tripathi
Keyword(s):  
Bone Marrow ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
North India ◽  
Care Hospital ◽  
Bone Marrow Evaluation ◽  
Haematological Study

scholarly journals Clinicohematological study of spectrum of myeloproliferative neoplasms in a tertiary care hospital

2020 ◽  
Vol 11 (3) ◽  
pp. 3710-3718
Author(s):  
Sonal Gupta ◽  
Sujata R. Kanetkar
Keyword(s):  
Bone Marrow ◽  
High Risk ◽  
Tertiary Care Hospital ◽  
Risk Group ◽  
Myeloproliferative Neoplasms ◽  
Tertiary Care ◽  
Care Hospital ◽  
Trephine Biopsy ◽  
Maximum Serum ◽  
Hasford Score

Myeloproliferative neoplasms (MPNs) are a group of disorders of hematopoietic stem cells which were initially recognised by William Dameshek in 1951. Objectives of the study were to diagnose and classify cases of myeloproliferative neoplasms according to 2016 revision of WHO classification of myeloid neoplasms and acute leukaemias, to study various haematological parameters of cases of MPNs (Peripheral smear findings, bone marrow aspirate and trephine biopsy) and their clinical manifestations, to record the cytogenetic/molecular genetic abnormalities of the cases and to categorise CML patients according to Hasford Risk Score as a predictor of prognosis. This study was a prospective study carried out in the Department of Pathology of a tertiary care hospital over two years from June 2016 to September 2018. The study included a total of 41 cases of MPNs. The cases of CMLs were diagnosed on peripheral blood findings, Bone marrow aspiration, Trephine biopsy Serum LDH and uric acid. CML was the most common MPN encountered (37/41; 90.24%) in the present study. Maximum serum LDH elevation was observed in CML cases with a mean value of 1396.6 U/L. Of the 37 CML cases, as per Hasford score, 17 cases were categorised into a low-risk group, 17 cases into an intermediate-risk group and 3 cases into a high-risk group. In the present study of Hasford score in CML cases, it was found that it helps in making a better-informed decision about the adaption of alternative high-risk treatment, and was of value in oncology practice.

scholarly journals Spectrum of hematological diseases diagnosed by bone marrow examination in a tertiary care hospital

2019 ◽  
Vol 6 (2) ◽  
pp. 185-189
Author(s):  
M Atchyuta ◽  
◽  
P Premalatha ◽  
I V Renuka ◽  
P A. V Krishnamashary ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Bone Marrow Examination ◽  
Care Hospital ◽  
Hematological Diseases
Sign in / Sign up

Export Citation Format

Share Document