scholarly journals Histopathologic Pattern of Gastric Cancer in Bangladesh

1970 ◽  
Vol 5 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Sk Md Jaynul Islam ◽  
Syed Mokarram Ali ◽  
Salahuddin Ahmed ◽  
Quazi Dil Afroz ◽  
Rubaiyat Chowdhury ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Hodgkin’S Lymphoma ◽  
Malignant Neoplasm ◽  
Endoscopic Biopsy ◽  
Gastric Biopsy ◽  
Hodgkin's Lymphoma ◽  
Female Ratio ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
The Mean

Incidence of gastric carcinoma as well as other gastric malignancies is increasing day by day in the whole world as well as in Bangladesh. Prevalence of Helicobacter pylori in this country is an important contributing factor in this increasing trend of gastric malignancies. A study was carried out at the Department of Histopathology, Delta Hospital Limited, Dhaka to find out patterns of gastric malignancies in Bangladesh. All endoscopic gastric biopsy received during the stipulated period from January to December 2007, irrespective of age, sex and clinical suspicion, samples were included in the study. During the period total 1543 gastric biopsy samples were received, which were 7.95% of all the received (19410) samples. The endoscopic gastric biopsy samples were received from almost all the geographic locations of Bangladesh. Among those 5 (0.3%) samples were discarded from the study due to superficial inadequate biopsy. Out of 1538 cases 636 (41.35%) cases were malignant neoplasm of stomach, 493 (32.05%) were chronic active gastritis, 150 (9.75%) were chronic gastritis with intestinal metaplasia, 208 (13.52%) were chronic peptic ulcer, 48 (3.12%) were gastric polyp and 11 (0.72%) others. Among 636 gastric malignancies 625 (98.27%) were gastric adenocarcinoma and 11 (1.73%) were non Hodgkin's lymphoma. Most 357 (57.12%) of the gastric adenocarcinomas were poorly differentiated, 80 (12.8%) were well differentiated and 84 (13.44%) were moderately differentiated. Out of 625 cases, 104 (16.64%) cases were mucin secreting adenocarcinoma. Out of 11 Non Hodgkin's Lymphoma cases 10 were male and 01 was female. For adenocarcinoma male and female ratio was 2.36:1. Among the gastric carcinoma group the youngest person affected was of 16 year and the oldest person was of 100 year with the mean age 43.14 year. Among the Non Hodgkin's lymphoma group the mean age was 45 year with the range from 22 year to 65 year. Among the gastric malignancies, 275 (44%) cases were from Chittagong division, 188 (30.08%) from Dhaka division, 108 (17.28%) from Rajshahi division, 58 (9.28%) from Khulna division and others from Sylhet and Barisal division. It reflects very high incidence of gastric malignancies in comparison to other pathological changes in gastric endoscopic biopsy. It also reflects that between 16 year to 100 year no age is immune to the disease. Key Words: Histopathologic pattern, Gastric carcinoma.   doi: 10.3329/jafmc.v5i1.2846 JAFMC Bangladesh. Vol 5, No 1 (June) 2009 pp.21-24

Pyothorax-Associated Lymphoma: A Review of 106 Cases

2002 ◽  
Vol 20 (20) ◽  
pp. 4255-4260 ◽  
Author(s):  
Shin-ichi Nakatsuka ◽  
Masayuki Yao ◽  
Yoshihiko Hoshida ◽  
Satoru Yamamoto ◽  
Keiji Iuchi ◽  
...  
Keyword(s):  
B Cell ◽  
Hodgkin’S Lymphoma ◽  
Pleural Cavity ◽  
Hodgkin's Lymphoma ◽  
Cell Phenotype ◽  
Female Ratio ◽  
Non Hodgkin’S Lymphoma ◽  
Chronic Inflammatory Condition ◽  
Non Hodgkin's Lymphoma ◽  
History Of

PURPOSE: Pyothorax-associated lymphoma (PAL) is a non-Hodgkin’s lymphoma developing in the pleural cavity after a long-standing history of pyothorax. Full details of PAL are provided here.PATIENTS AND METHODS: Clinical and pathologic findings were reviewed in 106 patients with PAL collected through a nationwide survey in Japan.RESULTS: Age of the patients with PAL was 46 to 82 years (median, 64 years), with a male/female ratio of 12.3:1. All patients had a 20- to 64-year (median, 37-year) history of pyothorax resulting from artificial pneumothorax for treatment of pulmonary tuberculosis (80%) or tuberculous pleuritis (17%). The most common symptoms on admission were chest and/or back pain (57%) and fever (43%). Laboratory data showed that the serum neuron-specific enolase level was occasionally elevated (3.55 to 168.7 ng/mL; median, 18.65 ng/mL), suggesting a possible diagnosis of small-cell lung cancer. Histologically, PAL usually showed a diffuse proliferation of large cells of B-cell type (88%). In situ hybridization study showed that PAL in 70% of the patients was Epstein-Barr virus (EBV)-positive. PAL was responsive to chemotherapy, but the overall prognosis was poor, with a 5-year survival of 21.6%.CONCLUSION: This study established the distinct nature of PAL as a disease entity. PAL is a non-Hodgkin’s lymphoma of exclusively B-cell phenotype in the pleural cavity of patients with long-standing history of pyothorax, and is strongly associated with EBV infection. Development of PAL is closely related to antecedent chronic inflammatory condition; therefore, PAL should be defined as malignant lymphoma developing in chronic inflammation.

Collagen Type IV as Independent Prognostic Factor for Non-Hodgkin’s Lymphoma.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4708-4708
Author(s):  
Liljana Hadzi-Pecova ◽  
Gordana Petrusevska ◽  
Irina Panovska ◽  
Svetlana Stankovic ◽  
Aleksandar Stojanovik
Keyword(s):  
Basement Membrane ◽  
Hodgkin’S Lymphoma ◽  
Collagen Type ◽  
International Prognostic Index ◽  
Hodgkin's Lymphoma ◽  
Collagen Type Iv ◽  
Female Ratio ◽  
Type Iv ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Abstract Many attempts have been made recently to improve the prognostic systems for non-Hodgkin’s lymphoma (NHL). There are no available data in the literature regarding the influence of intactness of the basement membrane of the blood vessels on the prognosis of NHL, when compared with the clinical characteristics of the disease. On the other hand, it is known that the integrity of the basement membrane is marker for the aggressiveness of the malignant disorders. In order to analyze the association of the expression patterns of collagen type IV on the prognosis of the patients with NHL we have conducted a retrospective study. We have evaluated 136 patients diagnosed and treated as NHL in the last ten years at the Clinic of Hematology, Medical Faculty -Skopje. All 136 patients with representative tumor tissues were diagnosed with NHL according to the REAL classification (71 patients were diagnosed as diffuse large cell lymphoma, 28 as follicular lymphoma, 24 as small lymphocytic lymphoma and 14 as marginal zone lymphoma). Median age of the patients was 49 years, with male: female ratio 1.5:1.0. The application of international prognostic index (IPI) identified four risk groups with predicted five-years survival rates of 87%, 82%, 18% and 0%, with statistical significance (p< 0.001). Using immunoperoxidase staining we have analyzed the collagen type IV expressing patterns in our group of patients, and defined three tumor invasive grades: high tumor invasive grade as total lack of immunoreactivity for collagen type IV (68 patients), medium-presented as discontinuous expression (56 patients) and low-as a continuous linear expression (14 patients). The 5 year overall survival rate was significantly lower (p<0.01) in patients with high invasive grade than in patients with medium or low invasive grade (54% vs. 78% and 100%). Further, in multivariate analysis collagen type IV expression appeared as an independent survival-predicting factor together with the parameters of the IPI. Our results indicated that the expression of a collagen type IV immunoreactivity could predict the outcome of patients with NHL. However, further studies are needed to define the role of collagen type IV in the future prognostic systems for NHL.

scholarly journals An unusual case of gastric carcinoma with synchronous non-Hodgkin's lymphoma

1998 ◽  
Vol 39 (5) ◽  
pp. 463 ◽  
Author(s):  
Sung Ha Park ◽  
Sun Young Rha ◽  
Dae Keun Shim ◽  
Hyun Jung Rho ◽  
Nae Choon Yoo ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Hodgkin’S Lymphoma ◽  
Unusual Case ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Antiphospholipid Antibodies: Prevalence, Clinical Significance and Correlation to Cytokine Levels in Acute Myeloid Leukemia and Non-Hodgkin’s Lymphoma

1993 ◽  
Vol 70 (04) ◽  
pp. 568-572 ◽  
Author(s):  
Roberto Stasi ◽  
Elisa Stipa ◽  
Mario Masi ◽  
Felicia Oliva ◽  
Alessandro Sciarra ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Clinical Significance ◽  
Antiphospholipid Antibodies ◽  
Myeloid Leukemia ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Tnf Alpha ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Acute Myeloid

SummaryThis study was designed to explore the prevalence and clinical significance of elevated antiphospholipid antibodies (APA) titres in patients affected by acute myeloid leukemia (AML) and highgrade non-Hodgkin’s lymphoma (NHL). We also analyzed possible correlations with circulating levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and the soluble form of the receptor for interleukin-2 (sIL-2r). Nineteen patients with de novo AML and 14 patients with newly-diagnosed NHL were investigated. Tests for APA included the measurement of anticardiolipin antibodies (ACA) with a solid-phase immunoassay, and the detection of the lupus-like anticoagulant (LA) activity. Five patients with AML (26.3%) and 5 patients with NHL (35.7%) presented elevated APA at diagnosis, as compared to 3 of 174 persons of the control group (p <0.0001). APA titres became normal in all patients responding to treatment, whereas nonresponders retained elevated levels. In addition, 6 patients (4 with AML and 2 with NHL), who had normal APA at diagnosis and were either refractory to treatment or in relapse, subsequently developed LA and/or ACA positivity. At presentation, the mean levels of IgG- and IgM-ACA in patients were not significantly different from Controls, and concordance between ACA and LA results reached just 30%. With regard to the clinical course, we were not able to detect any statistically significant difference between patients with normal and elevated APA. Pretreatment concentrations of IL-6 and TNF-alpha in AML, and sIL-2r in NHL were found significantly elevated compared to Controls (p = 0.003, p = 0.009 and p = 0.024 respectively). In addition, the levels of these cytokines correlated with IgG-ACA at the different times of laboratory investigations. These results demonstrate that APA may have a role as markers of disease activity and progression in some haematological malignancies.

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