scholarly journals Assessment of Short-term Outcomes of 10 mg Daily Amitriptyline Therapy in Globus Pharyngeus Patients

KYAMC Journal ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 75-77
Author(s):  
Muntasir Mahbub ◽  
Md Mahbubur Rahman
Keyword(s):  
Side Effects ◽  
Low Dose ◽  
Symptomatic Relief ◽  
Subjective Feeling ◽  
Short Term ◽  
Female Ratio ◽  
Globus Pharyngeus ◽  
Upper Gi Endoscopy ◽  
Term Basis ◽  
Per Oral

Background: Globus pharyngeus or feeling of a lump in the throat is a very common complaint in patients visiting the otolaryngology outpatient department. Pharmacotherapy with low dose amitriptyline has a significant effect in relieving the symptoms, although success rate varies among patients. Objectives: Aim for this study was to find out the benefits of low dose amitriptyline therapy in the management of Globus pharyngeus on a short term basis. Materials & Methods: This is an observational study conducted from Jan 2019 to Jan 2020. Total 50 patients were included in this study. Inclusion criteria were – subjective feeling of a lump in the throat persisting for more than 2 months, Clinical oral examination and Upper GI endoscopy revealed normal findings, age between 18–60 years of both sexes. All the patients were prescribed with 10mg Amitriptyline per oral at night for 2 months, and patients were followed during the course of treatment to assess relief of symptoms and to evaluate any side effects. Results: In this study male to female ratio was 1:4. Mean age of study group was 42.66 (_ 4.78) years. Symptomatic relief occurred in 37 (74%) patients. Increased somnolence was found in 21 patients (42%) during first 2 weeks of treatment, No improvement occurred in 8 patients (16%), and worsening of symptom occurred in 5 patients (10%). Conclusion: Low dose Amitriptyline is effective in alleviating symptoms of globus pharyngeus in most patients on a short-term basis. Although some minor side effects can occur, these are manageable. KYAMC Journal.2021;12(02): 75-77

Over-The-Counter Appetite Suppressants Containing Phenylpropanolamine Hydrochloride (PPA) and the Young Adult: Usage and Perceived Effectiveness

1983 ◽  
Vol 13 (2) ◽  
pp. 141-152 ◽  
Author(s):  
Lawrence R. Krupka ◽  
Arthur M. Vener
Keyword(s):  
Young Adults ◽  
Young Adult ◽  
Side Effects ◽  
Perceived Effectiveness ◽  
Short Term ◽  
Over The Counter ◽  
Appetite Suppressants ◽  
Phenylpropanolamine Hydrochloride ◽  
Term Basis ◽  
Diet Pills

A survey of 944 young adults regarding their usage and perceived effectiveness of over-the-counter (O-T-C) diet pills containing phenylpropanolamine hydrochloride (PPA) showed that 30.1 percent of the women had consumed these preparations during the year prior to the interview. Women who either perceived themselves as being very overweight and/or desired to lose the most poundage tended to consume more diet pills. About 25 percent of the women who had ingested appetite suppressants reported various side effects. The vast majority of women (86%) believed that the pills were useful only on a very short-term basis, or that they acted as placebos, with little or no anorectic action and/or that they were completely ineffective. Only 3.7 percent of the men had used an O-T-C diet preparation. In a second survey of 425 young adults the potentiality for overdosage was demonstrated by the 47 percent of the women who had used two or more O-T-C preparations (diet pills and/or decongestants) containing PPA in a twenty-four-hour period and the 10 percent who had consumed three or more.

The use of low-dose trazodone in the treatment of painful diabetic neuropathy

1999 ◽  
Vol 89 (9) ◽  
pp. 468-471 ◽  
Author(s):  
RC Wilson
Keyword(s):  
Side Effects ◽  
Diabetic Neuropathy ◽  
Low Dose ◽  
Symptomatic Relief ◽  
Complete Relief ◽  
Diabetic Patients ◽  
Low Doses ◽  
Painful Diabetic Neuropathy ◽  
Effective Treatment Option ◽  
Distal Symmetrical Polyneuropathy

Thirty-one adult diabetic patients with painful distal symmetrical polyneuropathy were treated with low doses of oral trazodone (50 or 100 mg/day). After 2 weeks of therapy, 19 patients (61.3%) experienced symptomatic relief, and 7 (22.6%) experienced complete relief. Although 8 patients (25.8%) discontinued the drug because of side effects, these were relatively minor (dizziness, headache, insomnia). Low-dose trazodone is recommended as an effective treatment option for painful diabetic neuropathy.

Ex juvantibus approach for chronic posterior laryngitis: results of short-term pantoprazole therapy

1999 ◽  
Vol 113 (8) ◽  
pp. 734-739 ◽  
Author(s):  
Walter Habermann ◽  
Andreas Eherer ◽  
Franz Lindbichler ◽  
Johann Raith ◽  
Gerhard Friedrich
Keyword(s):  
Side Effects ◽  
Proton Pump ◽  
Case History ◽  
Therapeutic Option ◽  
Short Term ◽  
Globus Pharyngeus ◽  
Symptom Questionnaire ◽  
History Of ◽  
Pharyngeal Reflux

AbstractThe aim of this study was to investigate whether patients with chronic posterior laryngitis and symptoms of gastro-pharyngeal reflux benefit from a six-week therapy with pantoprozole. Twenty-nine out-patients with voice disorders (case history of at least two months) and simultaneous symptoms of gastropharyngeal reflux were recruited for this study. At the entry to the study a symptom questionnaire and a videolaryngo/stroboscopy were completed. The symptom questionnaire and the video-laryngo/stroboscopy were repeated after the six weeks of therapy with pantoprazole 40 mg once a day and again six weeks and three months after this follow-up, during which time the patient was without therapy.Hoarseness, globus pharyngeus, sore throat, heartburn, and coughing were the symptoms which showed a significant (p<0.05) recovery at the follow-ups (mean of hoarseness index: 7.28 to 0.92; mean of globus pharyngeus index: 3.14 to 0.58; mean of heartburn index: 2.86 to 0.5; mean of cough index: 1.72 to 0.25; mean of throat soreness index: 1.72 to 0.15). Laryngoscopy scores of the posterior laryngeal region, the glottic and the supraglottic region showed statistically significant improvement (p<0.05) after the treatment with pantoprazole. The therapeutic effect exceeded the drug administration until the last follow-up (after three months). The medication was tolerated without side-effects in all patients.A primary (ex juvantibus) therapy with proton pump inhibitors seems to be a therapeutic option for patients with long-lasting chronic inflammation of the larynx not responding to common therapy. In this case a six-week course of treatment has been shown to be sufficient.

scholarly journals Zolpidem dependence with frontal lobe syndrome: a case report

2017 ◽  
Vol 6 (12) ◽  
pp. 2936 ◽  
Author(s):  
Udayan Majumder ◽  
Rajesh Das ◽  
Rajkumar Lenin Singh
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Binding Site ◽  
Efficacy And Safety ◽  
Short Term ◽  
Gaba A ◽  
Acid Type ◽  
Benzodiazepine Binding ◽  
Term Basis ◽  
Frontal Lobe Syndrome

Zolpidem is a non-benzodiazepine sedative hypnotic that binds to the benzodiazepine binding site on the gammaaminobutyric acid type A (GABA-A) receptors. It is the most commonly prescribed sleep medication which has been shown to be effective for treating insomnia on a short-term basis with fewer side effects than traditional benzodiazepines, which are feared for their abuse and dependence potential. Many studies have reported efficacy and safety of zolpidem in treatment of insomnia keeping in mind about its low abuse, and dependence capability. We present a case of zolpidem dependence in a 36-year-old male to emphasize that zolpidem also should be judiciously prescribed under supervision so that it does not develop tolerance, abuse and dependence.

Bipolar radiofrequency induced thermotherapy and 1064 nm Nd:Yag laser in endovenous occlusion of insufficient veins: short term follow up results

VASA ◽  
2011 ◽  
Vol 40 (3) ◽  
pp. 235-240 ◽  
Author(s):  
Krnic ◽  
Sucic
Keyword(s):  
Side Effects ◽  
Success Rate ◽  
Nd:Yag Laser ◽  
Main Stem ◽  
Short Term ◽  
Main Trunk ◽  
Bipolar Radiofrequency ◽  
Saphenous Veins ◽  
Skin Redness ◽  
Complete Failure

Background: The aim of this study is to report our results in main stem vein closure using the bipolar radiofrequency induced thermotherapy (RFITT) system and the 1064nm Nd:Yag laser. Patients and methods: 44 incompetent main stem veins (37 great saphenous veins, one lesser saphenous vein, and 6 anterior accessory saphenous veins) in 29 patients were treated using RFITT. 53 incompetent main stem veins (45 great saphenous veins, 4 lesser saphenous veins, and 4 anterior accessory saphenous veins) in 43 patients were treated endovenously with 1064 nm Nd:Yag laser. All patients underwent postoperative duplex scanning within a month after procedure, as well as a short interview regarding postoperative discomfort. Results: In main stem veins treated with RFITT, the success rate within the first month was 86,4 % (38 out of 44 veins). Complete failure rate was 13,6 % (6 out of 44 veins). In 53 main stem veins treated by 1064 nm Nd:Yag laser, the success rate was 100 %, consisting of 98,1 % complete success (52/53 veins), and 1,9 % partial success (1/53 veins). None of the patients treated with RFITT experienced postoperative adverse effects, whereas 13/43 (30,2 %) patients treated with laser had to use oral analgesics after the treatment, and 21/43 (48,8 %) patients reported transient skin changes, such as bruising or skin redness. Conclusions: RFITT system was fairly efficient in the short term for closure of main trunk veins, whereas longer term results are still scarce. Postoperative side effects of RFITT were minimal. 1064nm Nd:Yag laser, according to short term results, proved to be very effective for main stem vein closure. Postoperative side effects related to 1064 nm Nd:Yag endovenous laser treatment proved to be minor, transient, and acceptable.

Short-term, low-dose ACTH therapy in West syndrome

2005 ◽  
Vol 36 (02) ◽  
Author(s):  
G Ramantani ◽  
M Tzitiridou ◽  
C Panteliadis
Keyword(s):  
Low Dose ◽  
West Syndrome ◽  
Short Term ◽  
Acth Therapy

CONTRACEPTION IN DIABETIC PATIENTS

1974 ◽  
Vol 77 (3_Suppl) ◽  
pp. S87-S94 ◽  
Author(s):  
J. Wiese ◽  
M. Osler
Keyword(s):  
Side Effects ◽  
Contraceptive Method ◽  
Low Dose ◽  
Unplanned Pregnancy ◽  
Intrauterine Device ◽  
Diabetic Patients ◽  
Intrauterine Contraception ◽  
Unwanted Pregnancies ◽  
Unreliable Method ◽  
Retrospective Investigation

ABSTRACT A retrospective investigation was made of contraception in diabetic women delivered in our department in 1969 and 1970. Seventy-nine (69 per cent) answered the questionnaires. About one third had found the contraceptive instruction insufficient. A shift from conventional to intrauterine contraception and sterilization was seen, but nearly 25% of the patients were still using conventional methods, mainly the condom. The patients consider this an unreliable method. Thirty-three patients were using intrauterine contraception. Although 10 of them had bleeding irregularities, all were satisfied with the method. Sterilization had been performed on 17 patients, all of whom were fully satisfied and had experienced no side effects. Four of 11 insulin-requiring diabetics, who have used combined oestrogen-progesterone medication have had difficulties in the regulation of the diabetes. Of 24 unwanted pregnancies 12 occurred since the hospitalization in 1969 and 1970. In diabetic women the contraceptive method should either be sterilization, intrauterine device or low dose progestagens, and only in a few cases conventional. A thorough contraceptive instruction as well as a close control of the diabetic women are of importance in order to avoid unplanned pregnancy. The best way to achieve this is by having an out-patient clinic in connection with the obstetrical department to supervise contraception in all diabetic women in the area.

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