A Comparison of the Electrophysiological and Anatomic Characteristics of Pacing Different Branches of the Left Bundle Conduction System

Introduction: Left bundle branch pacing (LBBP) is a rapidly growing conduction system pacing technique. However, little is known regarding the electrophysiological characteristics of different types of LBBP. We aimed to evaluate the electrophysiological characteristics and anatomic lead location with pacing different branches of the left bundle branch.Methods: Consecutive bradycardia patients with successful LBBP were enrolled and classified into groups according to the paced electrocardiogram and the lead location. Electrocardiogram, pacing properties, vectorcardiogram, and lead tip location were analyzed.Results: Ninety-one patients were enrolled, including 48 with the left bundle trunk pacing (LBTP) and 43 with the left bundle fascicular pacing (LBFP). The paced QRS duration in the LBTP group was significantly shorter than that in the LBFP group (108.1 ± 9.9 vs. 112.9 ± 11.2 ms, p = 0.03), with a more rightward QRS transition zone (p = 0.01). The paced QRS area in the LBTP group was similar to that during intrinsic rhythm (35.1 ± 15.8 vs. 34.7 ± 16.6 μVs, p = 0.98), whereas in the LBFP group, the paced QRS area was significantly larger compared to intrinsic rhythm (43.4 ± 15.8 vs. 35.7 ± 18.0 μVs, p = 0.01). The lead tip site for LBTP was located in a small fan-shaped area with the tricuspid valve annulus summit as the origin, whereas fascicular pacing sites were more likely in a larger and more distal area.Conclusions: Pacing the proximal left bundle main trunk produced better electrical synchrony compared with pacing the distal left bundle fascicles. A visualization technique can facilitate achieving LBTP.

Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging

Perivascular fibroblasts (PVFs) are recognized for their pro-fibrotic role in many central nervous system disorders. Like mural cells, PVFs surround blood vessels and express Pdgfrβ. However, these shared attributes hinder the ability to distinguish PVFs from mural cells. We used in vivo two-photon imaging and transgenic mice with PVF-targeting promoters (Col1a1 or Col1a2) to compare the structure and distribution of PVFs and mural cells in cerebral cortex of healthy, adult mice. We show that PVFs localize to all cortical penetrating arterioles and their offshoots (arteriole-capillary transition zone), as well as the main trunk of only larger ascending venules. However, the capillary zone is devoid of PVF coverage. PVFs display short-range mobility along the vessel wall and exhibit distinct structural features (flattened somata and thin ruffled processes) not seen with smooth muscle cells or pericytes. These findings clarify that PVFs and mural cells are distinct cell types coexisting in a similar perivascular niche.

Prevalence and patterns of coronary artery anomalies in 28,800 adult patients undergoing angiography in a large tertiary care centre in India

Coronary artery anomalies (CAAs) are a diverse group of disorders with varied clinical presentation and pathophysiological mechanisms. A majority of these anomalies are asymptomatic and often an incidental finding on coronary angiogram or autopsy. This retrospective study included 28,800 patients who underwent coronary angiography from 2016 to 2020. The coronary angiograms were reviewed by two independent reviewers and CAAs were documented. CAAs were classified into (a) anomalies of coronary artery connection, (b) anomalies of intrinsic coronary arterial anatomy and (c) anomalies of myocardial/coronary artery interaction as proposed by the European Society of Cardiology. Of the 28,800 coronary angiograms, CAAs were present in 4.12% with anomalies in the left coronary artery (LCA) being most common. Anomalies of coronary artery connection were most common (48.48%) followed by anomalies of myocardial/coronary artery interaction (34.49%) and anomalies of intrinsic coronary artery anatomy (17.03%). Among anomalies of coronary artery connection, absent left main trunk or split LCA with separate origins of left anterior descending coronary artery and left circumflex coronary artery from the left coronary sinus of Valsalva (22.59%) was most common. An intramural course or “myocardial bridge” had an incidence of 1.16% while incidence of coronary artery fistulae (CAF) was 0.115%.

Aplastic or twig-like middle cerebral artery and cardiogenic cerebral embolism mimicking moyamoya disease with RNF213 polymorphism: A case report

Progressive stenosis and occlusion of the bilateral internal carotid artery terminals and circle of Willis are typical features of Moyamoya disease. However, aplastic or twig-like middle cerebral artery (Ap/T-MCA)—wherein the unilateral main trunk of the middle cerebral artery (MCA) is not depicted, and a plexiform arterial network is formed—is similar to the findings of Moyamoya disease. Here, we describe a 78-year-old man who presented with mild right paralysis and aphasia. Magnetic resonance angiography (MRA) at admission did not show the bilateral MCAs. The findings were similar to those of Moyamoya disease, and his symptoms worsened after hospitalization. Endovascular treatment was performed, and the left MCA was completely recanalized. Later, paroxysmal atrial fibrillation was detected, and we finally determined that left MCA occlusion had occurred due to embolism. The right MCA was completely occluded at its origin, indicating an Ap/T-MCA. Embolic occlusion of the unilateral MCA and contralateral Ap/T-MCA made this case resemble Moyamoya disease in the acute stage. Even when chronic occlusion is suspected on MRA in acute cerebral infarction, endovascular treatment should be considered. Additionally, a heterotypic R4810K polymorphism was later found in the RNF213 gene. To our knowledge, this is the second report of Ap/T-MCA with the RNF213 gene polymorphism; however, their association remains unclear and requires further analyses.

Left Valsalva aneurysm as acute ischemia of the left main trunk: a case report

A 79-year-old woman was brought to the emergency room for chest pain. Acute coronary syndrome was suspected and coronary angiography revealed an aneurysm-like contrast accumulation in the sinus of Valsalva. Computed tomography revealed an aneurysm of the left Valsalva compressing the left coronary artery, which required surgical treatment.

Minimally Invasive Approaching in Hip Surgery—An Anatomical Investigation of 20 Specimens

Background and objectives: Based on the preparation of 20 formalin-fixed anatomical cadavers, the feasibility of the anterior, minimally invasive approach to the hip joint was investigated in each side of the body. The hypothesis of the study was that the Lateral Femoral Cutaneous Nerve can be spared under the use of this approach. Materials and Methods: The anterior approach to the hip was performed via an incision of 8 cm. The position of the nerve was noticed in relation to the skin incision, and the distance was measured in millimeters. The nerves main, gluteal and femoral trunk were distinguished and investigated for injury. Results: No injury of the main trunk was noticed. The average distance of the main trunk to the skin incision was 14.9 and 15.05 mm in the medial direction, respectively (p < 0.001). Injury of the gluteal branch has to be considered at an overall rate of 40%. Conclusions: The anterior, minimally invasive approach to the hip joint can be performed without injury of the Lateral Femoral Cutaneous Nerve.

A breeding record of the brown hawk owl (Ninox scutulata) in Assam, India

The brown hawk owl, Ninox scutulata (Raffles, 1822) is a common, medium sized bird of prey on the Indian subcontinent and listed as of least concern. Its distribution range extends up to eastern Siberia, Japan, the Andmans, the Malay Peninsula, the Great and Lesser Sundas, Wallacea, Taiwan, the Philippines and Australia. There are 11 well documented subspecies across this wide distribution. A pair of brown hawk owls was observed nesting on a Dillenia indica tree (Family Dilleniaceae), in Guwahati, Kamrup District, Assam, India. The nest was in a cavity at a height of about 4 m. The tree was about 14 m tall and the main trunk was about 7 m in girth. It had a dense canopy with its large elliptical leaves.

Abstract 1122‐000098: A New Technique to Prevent Ophthalmic Complications Prior to Middle Meningeal Artery Embolization

Introduction : Embolization of the Middle Meningeal Artery (MMA) is a minimally invasive procedure used as an alternative or adjunctive treatment of chronic subdural hematoma (cSDH). The benefits of MMA embolization have been attributed to targeting of the pathophysiology of cSDH which currently favors a process of increasing inflammatory response causing immature and leaky neovascularization. The major dural arteries and hazards associated with their embolization have been thoroughly described in past literature. The unintended embolization of orbital arteries leading to blindness is the most significant hazard associated with MMA embolization. The purpose of this study is to present 5 cases demonstrating the success of our technique in the treatment of cSDH while preventing the possibility of blindness by coiling the anastomotic vessel between MMA and Ophthalmic Artery (OA) branches prior to particle embolization. Methods : After doing an Internal Carotid Artery (ICA) run and ensuring the origination of the OA from the ICA and observing retinal blush, we routinely infused 10–20mcg of Nitroglycerine into the main trunk of MMA through a microcatheter to dilate and better visualize the MMA branches including anastomosis. If the meningeo‐ophthalmic collaterals were visualized during the follow‐up microcatheter run, we coil embolized the proximal segment of those collaterals through the same microcatheter. We then infused 100–300µm particles through the main branches of the MMA supplying the dura. Results : Of the 39 patients who underwent MMA embolization for cSDH, 5 received MMA/OA collateral variants coil embolization followed by successful particle embolization of all MMA branches supplying the dura without complication. Conclusions : In our cSDH patients, the collaterals from MMA to Ophthalmic or Lacrimal branches were safely coil embolized before complete particle embolization of the MMA dural branches. In a few patients these collaterals became obvious after inducing vasodilatation. None of these patients had major complications. This technique may be safer, more effective and cheaper than wedging, gluing or low pressure infusion. Our literature search did not find a similar technique used in this application.

Evaluation of Erosion-Prone Areas in Lamurde River Basin, Nigeria Using Morphometric Prioritization Method

Remote sensing and GIS techniques have been increasingly used in characterization of drainage basin and prioritization of erosion prone watershed. This study uses remote sensing and GIS to characterise drainage basin morphometry and prioritize soil erosion prone sub watershed in the Lamurde watershed in Taraba state Nigeria. The study adopted standard formulae and methods to compute the morphometric parameters. The Lamurde watershed was delineated to fifteen sub-watersheds with each coded as WS1 to WS15. The result of the findings reveals that Lamurde watershed has a dendritic to sub-dendritic drainage pattern with the smaller streams intersecting the main trunk at acute angles. The findings reveal that Lamurde is a ninth order stream with total area of 1,458.66 km2 and a perimeter of 395.93 km. The basin also has 258,493 total number of streams. The main soil types in the Lamurde basin are fluvisol, lithosol, ferric luvisols and humic nitosols. The surface soil texture of the area is mainly loamy type and particle size classes are fine loamy type. Depth of soil varies from shallow to very deep and having parent material derived from sandstones, mudstones and shales. The findings of the study reveals that watershed: WS7, WS8, WS5, WS11, WS15, WS14, WS2 and WS6 in ascending order are very highly vulnerable to soil erosion. Despite inherent limitation in the use of morphometric parameters to prioritize erosion prone sub watersheds, it is most suitable in the present circumstances because of inadequate information and lack of functional measurement station in the basin, since they have more stable and accessible data on which prioritization of the watersheds can be based on. This study contributes to the problem of dearth of information regarding the susceptibility to erosion in the Lamurde River Basin in Taraba State Nigeria. Based on this findings, these sub watersheds should be given higher priority on any soil conservation intervention measures in the study area. This will go a long way to help address the problem of soil erosion in the area.