Fluorescein Angiographic Findings and Recurrence of Human Leukocyte Antigen-B27-Associated Anterior Uveitis

Purpose: To evaluate the associations of fluorescein angiographic findings with recurrence of human leukocyte antigen (HLA)-B27-associated anterior uveitis.Methods: Medical records of 56 eyes of 56 patients with first-onset, treatment-naive HLA-B27-associated anterior uveitis who performed fluorescein angiography was analyzed. We recorded the fluorescein angiographic findings of optic disc and peripheral vascular leakage and anterior chamber inflammation at the first visit. The 1-year recurrences and times to the first recurrences and the associations between them were investigated.Results: Fluorescein angiography revealed optic disc leakage in 23 patients (41.1%) and peripheral vascular leakage in 36 (64.3%). We found no significant association between the anterior chamber inflammation grade and either optic disc (p = 0.841) or peripheral vascular (p = 0.775) leakage. The 1-year recurrence rate in the optic disc leakage-positive group was significantly higher than in the leakage-negative group (14 patients, 60.9% vs. 11 patients, 33.3%) (p = 0.041), but peripheral vascular leakage status did not significantly affect the recurrence rate (19 leakage-positive patients, 52.8% vs. 8 leakage-negative patients, 40.0%) (p = 0.602). The time to first recurrence was not significantly associated with age (p = 0.772), anterior chamber inflammation (p = 0.841), optic disc leakage (p = 0.108), or systemic corticosteroid use (p = 0.321).Conclusions: We sought correlations between angiographic leakage in patients with HLA-B27-associated anterior uveitis, and the 1-year recurrence rate and the time to first recurrence. Careful follow-up for at least 1 year after initial diagnosis is essential to monitor possible recurrence in patients with optic disc leakage.

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Peripheral Vascular Leakage in Uveitis: Clinical and Angiographic Findings

Ophthalmology ◽

10.1016/j.ophtha.2015.01.011 ◽

2015 ◽

Vol 122 (6) ◽

pp. 1269-1270 ◽

Cited By ~ 12

Author(s):

John P. Campbell ◽

Robert M. Beardsley ◽

Neal V. Palejwala ◽

Justin T. Baynham ◽

Wonchon Lin ◽

...

Keyword(s):

Vascular Leakage ◽

Peripheral Vascular ◽

Angiographic Findings

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Association of Killer Cell Immunoglobulin-like Receptor and Human Leukocyte antigen-C Genotype with HLA-B27 Associated Acute Anterior Uveitis and Idiopathic Acute Anterior Uveitis in a Chinese Han Population

Ocular Immunology and Inflammation ◽

10.1080/09273948.2020.1808228 ◽

2020 ◽

pp. 1-6

Author(s):

Yun-Xia Liu ◽

Nan Guo ◽

Ming-Hua Xu ◽

Gui-Fang Ren

Keyword(s):

Human Leukocyte Antigen ◽

Anterior Uveitis ◽

Killer Cell ◽

Human Leukocyte ◽

Chinese Han Population ◽

Hla B27 ◽

Acute Anterior Uveitis ◽

Chinese Han ◽

Han Population ◽

Leukocyte Antigen

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Recent Developments in HLA B27 Anterior Uveitis

Frontiers in Immunology ◽

10.3389/fimmu.2020.608134 ◽

2021 ◽

Vol 11 ◽

Author(s):

Denis Wakefield ◽

Daniel Clarke ◽

Peter McCluskey

Keyword(s):

Anterior Uveitis ◽

Association Studies ◽

Immunosuppressive Treatment ◽

Human Leukocyte ◽

Hla B27 ◽

Research Attention ◽

Large Gene ◽

Bowel Diseases ◽

Recent Developments

There has been steady progress in understanding the pathogenesis, clinical features, and effective treatment of acute anterior uveitis (AU) over the past 5 years. Large gene wide association studies have confirmed that AU is a polygenic disease, with overlaps with the seronegative arthropathies and inflammatory bowel diseases, associations that have been repeatedly confirmed in clinical studies. The role of the microbiome in AU has received increased research attention, with recent evidence indicating that human leukocyte antigen B27 (HLA B27) may influence the composition of the gut microbiome in experimental animals. Extensive clinical investigations have confirmed the typical features of acute AU (AAU) and its response to topical, regional and systemic immunosuppressive treatment. Increased understanding of the role of cytokines has resulted in studies confirming the value of anti-cytokine therapy [anti–tumor necrosis factor (anti-TNF) and interleukin 6 (IL-6) therapy] in severe and recurrent cases of AAU, particularly in subjects with an associated spondyloarthopathy (SpA) and in juvenile idiopathic arthritis (JIA)–associated AAU.

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CFH I62V as a Putative Genetic Marker for Posner-Schlossman Syndrome

Frontiers in Immunology ◽

10.3389/fimmu.2021.608723 ◽

2021 ◽

Vol 12 ◽

Author(s):

Ming Ming Yang ◽

Hong Yan Sun ◽

Ting Meng ◽

Shan Hu Qiu ◽

Qi Qiao Zeng ◽

...

Keyword(s):

Intraocular Pressure ◽

Genetic Association ◽

Association Analysis ◽

Anterior Uveitis ◽

Genetic Background ◽

Interaction Analysis ◽

Human Leukocyte ◽

Hla B27 ◽

Complement Pathway ◽

Increased Risk

Objective: Posner-Schlossman syndrome (PSS), also known as glaucomatocyclitic crisis, is an ocular condition characterized by recurrent attacks of anterior uveitis and raised intraocular pressure. Previous studies by our team and others have identified the genetic association of complement pathway genes with uveitis and glaucoma. This study aimed to investigate the complement genes in PSS patients with the view of elucidating the genetic background of the disease.Methods: A total of 331 subjects (56 PSS patients and 275 controls) were recruited for this study. We selected 27 variants in six complement pathway genes (SERPING1, C2, CFB, CFH, C3, and C5) and detected them using TaqMan single nucleotide polymorphism (SNP) Genotyping Assays. Univariate SNP association analysis, haplotype-based association analysis, gene-gene interaction analysis among complement genes, and genotype-phenotype correlation analysis were performed.Results: Among the 27 variants of six complement pathway genes, the functional variant I62V (rs800292) at the CFH gene was found to be significantly associated with PSS; there was a significant increase in the frequency of A allele and AA homozygosity in PSS patients than in controls (P = 1.79 × 10−4; odds ratio (OR) 2.18, 95% CI: 1.44–3.29; P = 4.65 × 10−4; OR 3.66, 95% CI: 1.70–7.85, respectively). The additive effect of CFH-rs800292 and SERPING1-rs3824988 was identified with an OR of 12.50 (95% CI: 2.16–72.28). Genotype-phenotype analysis indicated that the rs800292 AA genotype was associated with a higher intraocular pressure and higher frequency of recurrence. Unlike a high proportion of human leukocyte antigen (HLA)-B27 positivity in anterior uveitis, only 3 in 56 (5.36%) PSS patients were HLA-B27 positive. In addition, one haplotype block (GC) in the SERPING1 gene showed a nominal association with PSS with an increased risk of 2.04 (P = 0.01; 95% CI: 1.18–3.53), but the P-value could not withstand the Bonferroni correction (Pcorr > 0.05).Conclusion: This study revealed a genetic association of a CFH variant with PSS as well as its clinical parameters, implying that the alternative complement pathway might play an important role in the pathogenesis of PSS. Further studies to enrich the understanding of the genetic background of PSS and the role of the complement system in ocular inflammation are warranted.

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