Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography

Bromazepam emulates the inhibitory effect of the neurotransmitter gamma-aminobutyric acid (GABA) and can lead to impaired visuomotor performance. However, few studies have evaluated its effects on cortical coupling in target shooting activities. The present study aimed to analyze the acute effects of bromazepam administration in a target shooting task and the EEG theta rhythm coherence between frontal, temporal, and motor cortical areas in four shooting preparation periods. Thus, a double blind, crossover study was conducted with 30 subjects under two conditions: bromazepam (6mg) and placebo, with electroencephalographic analysis to simultaneously study the theta rhythm coherence in frontal, temporal, and motor cortex in a target shooting task; and the possible interferences of bromazepam administration. Subjects in the bromazepam group showed lower performance on the task compared to placebo (p=0.001). In addition, our analysis showed decreased coherence between regions in the same hemisphere, increased theta rhythm coherence in interhemispheric regions in frontal, temporal and motor cortex at different intervals in the preparation preceding the shooting (p=0.001). The use of bromazepam may influence task execution, possibly due to neurochemical modulation, during decision making, developing shooting preparation strategies, as well as interfering with the flow of information at the level of attention during task execution.

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Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double‐blind, crossover study

Physiological Reports ◽

10.14814/phy2.15018 ◽

2021 ◽

Vol 9 (17) ◽

Author(s):

Benjamin De Becker ◽

Emeline Hupkens ◽

Laurence Dewachter ◽

Catherine Coremans ◽

Cédric Delporte ◽

...

Keyword(s):

Oxidative Stress ◽

Arterial Stiffness ◽

Crossover Study ◽

Acute Effects ◽

Double Blind ◽

Blind Crossover Study ◽

Double Blind Crossover Study

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The Plaque Inhibitory Effect of Aloe Vera Mouthrinse in A Four Day De Novo Plaque Formation Model- A Randomized, Double Blind Crossover Study

IOSR Journal of Dental and Medical Sciences ◽

10.9790/0853-1508099297 ◽

2016 ◽

Vol 15 (08) ◽

pp. 92-97

Author(s):

Dr Anika Daing ◽

Dr Madhuri Alankar Sawai ◽

Dr Ashu Bhardwaj ◽

Dr Zeba Jafri ◽

Dr Nishat Sultan

Keyword(s):

Crossover Study ◽

De Novo ◽

Aloe Vera ◽

Inhibitory Effect ◽

Plaque Formation ◽

Formation Model ◽

Double Blind ◽

Blind Crossover Study ◽

Double Blind Crossover Study

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Particle Depletion Does Not Remediate Acute Effects of Traffic-related Air Pollution and Allergen. A Randomized, Double-Blind Crossover Study

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/rccm.201809-1657oc ◽

2019 ◽

Vol 200 (5) ◽

pp. 565-574 ◽

Cited By ~ 21

Author(s):

Denise J. Wooding ◽

Min Hyung Ryu ◽

Anke Hüls ◽

Andrew D. Lee ◽

David T. S. Lin ◽

...

Keyword(s):

Air Pollution ◽

Crossover Study ◽

Acute Effects ◽

Double Blind ◽

Blind Crossover Study ◽

Double Blind Crossover Study

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Pharmacokinetics and Tolerability of Factor XIII Concentrates Prepared from Human Placenta or Plasma: a Crossover Randomised Study

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649787 ◽

1995 ◽

Vol 74 (02) ◽

pp. 622-625 ◽

Cited By ~ 29

Author(s):

H H Brackmann ◽

R Egbring ◽

A Ferster ◽

P Fondu ◽

J M Girardel ◽

...

Keyword(s):

Factor Xiii ◽

Bleeding Events ◽

Serious Adverse Events ◽

Double Blind ◽

Randomised Study ◽

The Mean ◽

Blind Crossover Study ◽

Double Blind Crossover Study ◽

Fxiii Activity ◽

Observation Period

SummaryThe pharmacokinetics and tolerability of factor XIII (FXIII) from plasma were compared with those of FXIII from placenta in a randomised, double-blind, crossover study involving 13 patients with congenital FXIII deficiency. Both FXIII activity and FXIII antigen were monitored. No difference was seen in the mean half-lives of the two preparations (9.3 days and 9.1 days for plasma and placenta FXIII activity, respectively). Response was similar for both preparations, but was slightly greater for FXIII from plasma.Similar results were found for recovery (65% vs 60%). The area under the data completed by extrapolation was significantly higher for FXIII from plasma. No differences between preparations in terms of efficacy or tolerability were observed. It can be concluded that treatment with FXIII concentrate from plasma is as efficient as with FXIII concentrate from placenta in terms of recovery and half-life. Both preparations were equivalent in terms of safety during the observation period. With the administration of monthly injections of approximately 30 U/kg serious bleeding events were prevented and no other serious adverse events occurred.

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Inhibition of Spontaneous Platelet Aggregation by Sulfinpyrazone

Thrombosis and Haemostasis ◽

10.1055/s-0038-1666900 ◽

1979 ◽

Vol 42 (02) ◽

pp. 621-625 ◽

Cited By ~ 1

Author(s):

G G Nenci ◽

G Agnelli ◽

M Berrettini ◽

P Parise ◽

E Ballatori

Keyword(s):

Platelet Aggregation ◽

Crossover Study ◽

Double Blind ◽

Platelet Aggregability ◽

Initiation Of Therapy ◽

Spontaneous Platelet Aggregation ◽

Blind Crossover Study ◽

Double Blind Crossover Study

SummaryIn a randomized double-blind crossover study in 16 patients with enhanced in vitro spontaneous platelet aggregation, sulfinpyrazone proved to be effective in normalizing platelet aggregability within 4 days after initiation of therapy.

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