scholarly journals Análise da eficácia da combinação do bevacizumabe e irinotecano para o tratamento de tumores gliais

2022 ◽  
Vol 11 (1) ◽  
pp. e37911125135
Author(s):  
Gustavo Soares Gomes Barros Fonseca ◽  
Maria Julia Fonseca Lima Leite ◽  
Ana Clara Nóbrega Costa ◽  
Pietra Possapp Andrade ◽  
Vivianne Maria Laranjeiras Monte Freire ◽  
...  

Os tumores gliais, ou gliomas, são o tipo mais comum de tumor cerebral e de alta incidência, sendo a maioria difusos e propensos à infiltração extensa no parênquima cerebral, causando recorrência do tumor. Os gliomas de alto grau, como os glioblastomas, são altamente angiogênicos e possuem altos níveis de fatores proangiogênicos, como o fator de crescimento endotelial vascular (VEGF), essencial para a neovascularização tumoral. O alvo para inibir o VEGF é o bevacizumabe, um anticorpo monoclonal humanizado, com associação do irinotecano, um inibidor da topoisomerase I. Dessa forma, o objetivo da seguinte revisão é analisar a eficácia da combinação do bevacizumabe e irinotecano para o tratamento de tumores gliais. Trata-se de uma revisão bibliográfica sistemática que utilizou as plataformas PubMed, SciELO e Google Scholar como base de dados para pesquisa de artigos científicos, com recorte temporal entre 2016 e 2021, na língua inglesa. De acordo com o mecanismo de busca, 3 resultados foram encontrados após os critérios de exclusão nas bases de dados PubMed e Google Scholar. Constatou-se, portanto, que a quimioterapia combinada de bevacizumabe e irinotecano é eficaz no tratamento de tumores gliais, ademais, a combinação de ambas as drogas possui maior taxa de sobrevida global do que apenas a terapia isolada do antiangiogênico bevacizumabe.

Author(s):  
D.V. Garbuzenko ◽  
D.V. Belov ◽  
A.A. Fokin ◽  
E.B. Milievskaia
Keyword(s):  

В обзоре рассматриваются современные представления об этиологии, патогенезе, факторах риска, диагностике и лечении острого панкреатита после операций на сердце в условиях искусственного кровообращения. Для поиска научных публикаций применяли базу данных PubMed, поисковую систему Google Scholar, а также при статейные списки литературы. Анализ литературы показал, что одной из причин острого панкреатита после кардиохирургических вмешательств является абдоминальная ишемия. При поздней диагностике и несвоевременно начатом лечении он ассоциируется с неблагоприятным прогнозом и высокой летальностью. Чтобы избежать неблагоприятных последствий, необходимы стратификация их риска и определение индивидуальной лечебной тактики. Разработка алгоритма ведения данной категории пациентов позволит стратифицировать их по группам риска и повысить эффективность лечебных мероприятий.


Mousaion ◽  
2016 ◽  
Vol 33 (3) ◽  
pp. 25-54
Author(s):  
Wanyenda Leonard Chilimo

 There is scant research-based evidence on the development and adoption of open access (OA) and institutional repositories (IRs) in Africa, and in Kenya in particular. This article reports on a study that attempted to fill that gap and provide feedback on the various OA projects and advocacy work currently underway in universities and research institutions in Kenya and in other developing countries. The article presents the findings of a descriptive study that set out to evaluate the current state of IRs in Kenya. Webometric approaches and interviews with IR managers were used to collect the data for the study. The findings showed that Kenya has made some progress in adopting OA with a total of 12 IRs currently listed in the Directory of Open Access Repositories (OpenDOAR) and five mandatory self-archiving policies listed in the Registry of Open Access Repositories Mandatory Archiving Policies (ROARMAP). Most of the IRs are owned by universities where theses and dissertations constitute the majority of the content type followed by journal articles. The results on the usage and impact of materials deposited in Kenyan IRs indicated that the most viewed publications in the repositories also received citations in Google Scholar, thereby signifying their impact and importance. The results also showed that there was a considerable interest in Swahili language publications among users of the repositories in Kenya.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1396-1399
Author(s):  
Disha Bhatero ◽  
Punam Sawarkar ◽  
Gaurav Sawarkar

Covid-19 is an infectious disease caused by novel Coronavirus. The overall prevalence rate of Covid-19 in Worldwide ( 9.94M )& it is (529 K) & (153 K) in India and Maharashtra. This situation can be considered under JanapadodhwansaVyadhi in Ayurveda. The primary purpose of Ayurveda  is the prevention of the disease in healthy individuals and eradication of disease, which are curable. Immunity comes under the Vyadhikshamatva. Further, Covid-19 infection is correlated with Vataj-Kaphaj Jwara. In Ayurveda Rasayana therapy to boost up immunity (Bala  & Vyadhikshamatva). The present study aimed to explore the concept of infectious disease and its prevention through different lifestyles described in Ayurveda. The above need-based information is collected from various Ayurvedicliterature (Laghutrayee, Bruhatryayi) along with numerous research articles from databases, such as PubMed, Google Scholar. All collected data were depicted in narrative form and tabular manner under different heads. Considering the above aspect in the prevention of Covid-19, the role of Ayurveda intervention may be proved more beneficial in Covid-19. Further, adoption of code of conduct may efficiently overcome the current pandemic situation by maintaining good immunity & implementation of Ahar, Vihar Vidhis, Dincharya, and Rutucharya& Sadvritta  for improving disease resistance.


2020 ◽  
Author(s):  
JAYDIP DATTA

CITATION : Citation Analysis ( Article ) Statistical Analysis of Stern Volmer equation Equation Applied on Biomolecules. ( Academia.edu , Google Scholar )


2020 ◽  
Author(s):  
Ainul Husna Hermanda Koto
Keyword(s):  

Cedera merupakan rasa sakit yang ditimbulkan akibat kecelakaan atau trauma, sehingga dapat menimbulkan cacat, luka, serta rusak pada otot atau sendi serta bagian lain dari tubuh. kecelakaan kerja merupakan kecelakaan yang terjadi berhubungan dengan hubungan kerja, termasuk penyakit yang timbul karena hubungan kerja. Oleh karena itu perlu diketahui beberapa faktor risiko penyebab kecelakaan tersebut sehingga dapat dilakukan upaya pencegahan. oleh karena itu perlu diketahui faktor risiko penyebab kecelakaan tersebut sehingga bisa dilakukan upaya pencegahan. Metode : Metoode penelitian yang digunakan yakni literature riview yaitu menganalisis artikel, , jurnal maupun text book, yang telah diterbitkan delapan tahun terakhir yang menggunakan google scholar,google book dan science direct. Tujuan : Pembahasan ini bertujuan agar menciptakan tempat kerja yang aman, sehat, serta bebas dari pencemaran lingkungan, sehingga dapat mengurangi dan atau bebas dari kecelakaan kerja dan penyakit akibat kerja yang pada akhirnya dapat meningkatkan efisiensi serta produktivitas kerja. Hasil : Pengetahuan tentang kesehatan dan keselamatan kerja (K3) yang baik bisa menurunkan angka kecelakaan kerja hingga tercapainya zero accident.


2019 ◽  
Author(s):  
Yogi Sugiarto Maulana
Keyword(s):  

File ini merupakan materi presentasi Workshop Pembuatan Profil Google Scholar (GS) dan Akun SINTA yang dilaksanakan 10 Januari 2019 berlokasi di Auditorium STISIP Bina Putera Banjar


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