scholarly journals Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-α, and JNK

2006 ◽  
Vol 21 (1) ◽  
pp. 95 ◽  
Author(s):  
Bark-Lynn Lew ◽  
Yunhi Cho ◽  
Jungmin Kim ◽  
Woo-Young Sim ◽  
Nack-In Kim
Keyword(s):  
Cell Signaling ◽  
Signaling Molecules

Analysis of Amphotericin B-Induced Cell Signaling with Chemical Inhibitors of Signaling Molecules

2006 ◽  
Vol 50 (4) ◽  
pp. 337-347 ◽  
Author(s):  
Kenichiro Matsuo ◽  
Hitoshi Hotokezaka ◽  
Naoya Ohara ◽  
Yuji Fujimura ◽  
Atsutoshi Yoshimura ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Amphotericin B ◽  
Signaling Molecules ◽  
Chemical Inhibitors

Stem Cell Signaling Molecules and Pathways

2017 ◽  
pp. 33-43
Author(s):  
Mirjana Pavlović ◽  
Ksenija Radotić
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Signaling Molecules

Cell signaling molecules as drug targets in lung cancer: an overview

2011 ◽  
Vol 17 (4) ◽  
pp. 286-291 ◽  
Author(s):  
Tapan K Mukherjee ◽  
Karan Paul ◽  
Srirupa Mukhopadhyay
Keyword(s):  
Lung Cancer ◽  
Cell Signaling ◽  
Drug Targets ◽  
Signaling Molecules

scholarly journals Reaction of Acylated Homoserine Lactone Bacterial Signaling Molecules with Oxidized Halogen Antimicrobials

2001 ◽  
Vol 67 (7) ◽  
pp. 3174-3179 ◽  
Author(s):  
S. A. Borchardt ◽  
E. J. Allain ◽  
J. J. Michels ◽  
G. W. Stearns ◽  
R. F. Kelly ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Marine Alga ◽  
Defense Mechanism ◽  
Microbial Control ◽  
Homoserine Lactone ◽  
Signaling Molecules ◽  
Chromobacterium Violaceum ◽  
Homoserine Lactones ◽  
Acylated Homoserine Lactone ◽  
Acylated Homoserine Lactones

ABSTRACT Oxidized halogen antimicrobials, such as hypochlorous and hypobromous acids, have been used extensively for microbial control in industrial systems. Recent discoveries have shown that acylated homoserine lactone cell-to-cell signaling molecules are important for biofilm formation in Pseudomonas aeruginosa, suggesting that biofouling can be controlled by interfering with bacterial cell-to-cell communication. This study was conducted to investigate the potential for oxidized halogens to react with acylated homoserine lactone-based signaling molecules. Acylated homoserine lactones containing a 3-oxo group were found to rapidly react with oxidized halogens, while acylated homoserine lactones lacking the 3-oxo functionality did not react. The Chromobacterium violaceum CV026 bioassay was used to determine the effects of such reactions on acylated homoserine lactone activity. The results demonstrated that 3-oxo acyl homoserine lactone activity was rapidly lost upon exposure to oxidized halogens; however, acylated homoserine lactones lacking the 3-oxo group retained activity. Experiments with the marine alga Laminaria digitata demonstrated that natural haloperoxidase systems are capable of mediating the deactivation of acylated homoserine lactones. This may illustrate a natural defense mechanism to prevent biofouling on the surface of this marine alga. The Chromobacterium violaceum activity assay illustrates that reactions between 3-oxo acylated homoserine lactone molecules and oxidized halogens do occur despite the presence of biofilm components at much greater concentrations. This work suggests that oxidized halogens may control biofilm not only via a cidal mechanism, but also by possibly interfering with 3-oxo acylated homoserine lactone-based cell signaling.

CS6-5 A new class of cell signaling molecules derived from aminoacyl-tRNA synthetases

Cytokine ◽  
2010 ◽  
Vol 52 (1-2) ◽  
pp. 73
Author(s):  
Xiang-Lei Yang ◽  
Quansheng Zhou ◽  
Mili Kapoor ◽  
Min Guo ◽  
Rajesh Belani ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Signaling Molecules ◽  
Trna Synthetases ◽  
New Class ◽  
Aminoacyl Trna Synthetases

scholarly journals The role of cell signaling molecules in the pathogenesis of glomerulonephritis in children

2021 ◽  
Vol 64 (2) ◽  
pp. 37-41
Author(s):  
Angela Ciuntu ◽  
Keyword(s):  
Nephrotic Syndrome ◽  
Cell Signaling ◽  
Clinical Manifestations ◽  
Signaling Molecules ◽  
Control Group ◽  
Healthy Children ◽  
Steroid Resistant ◽  
Steroid Resistant Nephrotic Syndrome ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive

Background: Cytokines are functional class of tiny proteins and glycoprotein and fundamentally they are monomers that function as soluble mediators in an autocrine or paracrine manner. Cytokines are produced by a number of cell types, predominantly leukocytes, and their targets implicate both immune and non-immune cells. Material and methods: This study was performed on 75 children with glomerulonephritis (GN), aged from 2 up to 17 years. There were 20 children with steroid-sensitive nephrotic syndrome (SSNS), 15 children with steroid-resistant nephrotic syndrome (SRNS), 20 children with chronic glomerulonephritis (CGN) nephrotic form and 20 children with CGN mixed form. This study was performed on patients experiencing disease relapse and clinical remission. The control group consisted of 20 healthy children. Results: The results of this study demonstrated increased levels of cell signaling molecules (IL-8, TNF-α, MCP-1, MIP-1α) in the urine during clinical manifestations, valuable result due to their major role in the immunopathogenic mechanism of proteinuria in nephrotic syndrome. Conclusions: Determination of urinary concentrations of cellular signaling molecules may be useful as a predictive non-invasive method for estimating disease activity, monitoring disease progression, differentiating steroid-sensitive nephrotic syndrome from steroid-resistant nephrotic syndrome, and assessing the effectiveness of treatment in children with different variants of GN

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