Stem Cell Signaling Molecules and Pathways

2017 ◽  
pp. 33-43
Author(s):  
Mirjana Pavlović ◽  
Ksenija Radotić
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Signaling Molecules

Molecular Switch of AhR in Repression or Activation of Stem Cell Signaling

2017 ◽  
Vol 12 (1) ◽  
pp. 28-33
Author(s):  
Yingqiu Xie ◽  
Xiuqing Zhang ◽  
Tomiris Atazhanova ◽  
Bindong Song ◽  
Qing Yang
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Molecular Switch

Conserved and Differentiated Functions of CIK Receptor Kinases in Modulating Stem Cell Signaling in Arabidopsis

2021 ◽  
Author(s):  
Yafen Zhu ◽  
Chong Hu ◽  
Yanwei Cui ◽  
Li Zeng ◽  
Sunjingnan Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Receptor Kinases

scholarly journals Cell Signaling by Urokinase-type Plasminogen Activator Receptor Induces Stem Cell–like Properties in Breast Cancer Cells

2010 ◽  
Vol 70 (21) ◽  
pp. 8948-8958 ◽  
Author(s):  
Minji Jo ◽  
Boryana M. Eastman ◽  
Drue L. Webb ◽  
Konstantin Stoletov ◽  
Richard Klemke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cell Signaling ◽  
Cancer Cells ◽  
Plasminogen Activator ◽  
Breast Cancer Cells ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Plasminogen Activator Receptor

Abstract 416: Pluripotent Stem Cell Signaling in Pediatric Heart Failure Patients

2016 ◽  
Vol 119 (suppl_1) ◽  
Author(s):  
Kathleen C Woulfe ◽  
Phillip Tatman ◽  
Anis Karimpour-Fard ◽  
Xuan Jiang ◽  
Karin Nunley ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cell ◽  
Cell Signaling ◽  
Dilated Cardiomyopathy ◽  
Pediatric Patients ◽  
Disease Process ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Cytokine Signaling ◽  
Common Indication ◽  
Pediatric Heart Failure

Pediatric heart failure is a heterogeneous disease process with congenital heart disease being the most common indication for heart transplantation in infants, and dilated cardiomyopathy (DCM) the most common indication in older children. Due to limitations of studying pediatric populations, there is no specific therapy for children with DCM. Importantly, the application of proven adult therapies to pediatric patients with DCM has resulted in no substantial improvement in survival over the past three decades. Therefore, there is a clear need for new approaches to better understand this disease process. In this study, we investigated global cardiac transcriptome and circulating serum proteome changes in pediatric patients with idiopathic dilated cardiomyopathy (IDC) and non-failing controls. Changes were identified in cytokine signaling, signal transduction, and transcription in pediatric IDC patients when compared to non-failing controls. Interestingly, these changes closely resemble the induction of stem cell pluripotency and signaling in resting stem cell populations. Importantly, the transcriptome changes are age-specific and were not observed in adult IDC patients. In addition, the protein profile in serum from pediatric IDC patients identified several factors related to inflammation, and treatment of cardiomyocyte-derived induced pluripotent stem cells (iPSC) with pediatric IDC serum recapitulated pathologic changes in gene expression, including expression of genes altered in the failing pediatric heart. These findings suggest that pathologic changes in cardiomyocytes may be triggered by circulating factors present in the serum resulting in pluripotent and stem cell signaling. These results provide several novel targets for future research and therapeutic intervention.

Analysis of Amphotericin B-Induced Cell Signaling with Chemical Inhibitors of Signaling Molecules

2006 ◽  
Vol 50 (4) ◽  
pp. 337-347 ◽  
Author(s):  
Kenichiro Matsuo ◽  
Hitoshi Hotokezaka ◽  
Naoya Ohara ◽  
Yuji Fujimura ◽  
Atsutoshi Yoshimura ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Amphotericin B ◽  
Signaling Molecules ◽  
Chemical Inhibitors

scholarly journals Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-α, and JNK

2006 ◽  
Vol 21 (1) ◽  
pp. 95 ◽  
Author(s):  
Bark-Lynn Lew ◽  
Yunhi Cho ◽  
Jungmin Kim ◽  
Woo-Young Sim ◽  
Nack-In Kim
Keyword(s):  
Cell Signaling ◽  
Signaling Molecules

scholarly journals A Synthetic Triterpenoid CDDO-Im Inhibits Tumorsphere Formation by Regulating Stem Cell Signaling Pathways in Triple-Negative Breast Cancer

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107616 ◽  
Author(s):  
Jae Young So ◽  
Janice J. Lin ◽  
Joseph Wahler ◽  
Karen T. Liby ◽  
Michael B. Sporn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cell Signaling Pathways
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