The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease

Background and objectives: Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors such as hypertension, diabetes, dyslipidemia, obesity, and hyperuricemia. We aim to investigate the relationship between uric acid and NAFLD in a non-obese and young population. Materials and Methods: This study was performed in January 2010–2019 with a group of 367 (225 patients in the NAFLD group and 142 in the control group) patients with liver biopsy-proven NAFLD or no NAFLD. Patients with NAFLD were classified according to the percentage of steatosis as follows, group I had 1–20% and group II >20%. Demographic, clinical, and laboratory (biochemical parameters) features were collected retrospectively. Results: The mean body mass index (BMI) and age of the patients were 26.41 ± 3.42 and 32.27 ± 8.85, respectively. The BMI, homeostatic model of assessment (HOMA-IR), and uric acid (UA) values of the NAFLD group were found to be significantly higher than those of the controls. A positive correlation was found between the NAFLD stage and UA. The following factors were independently associated with NAFLD: BMI, HOMA-IR, and UA. In addition, the cut-off value of UA was 4.75 mg/dl with a sensitivity of 45.8% and a specificity of 80.3%. Conclusions: UA is a simple, non-invasive, cheap, and useful marker that may be used to predict steatosis in patients with NAFLD.

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Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study

Frontiers in Endocrinology ◽

10.3389/fendo.2021.657856 ◽

2021 ◽

Vol 12 ◽

Author(s):

Qian Zhang ◽

Xiaoqian Ma ◽

Jie Xing ◽

Haiyun Shi ◽

Runkuan Yang ◽

...

Keyword(s):

Uric Acid ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Serum Uric Acid ◽

Mediation Analysis ◽

Fatty Liver Disease ◽

Total Population ◽

Nonalcoholic Fatty Liver ◽

Essential Components

ObjectiveObesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid (SUA) and obesity are essential components of metabolic syndrome (MetS), it is uncertain whether the incidence of NAFLD results from serum uric acid, obesity, or other potential factors based on previous studies.Patients and methodsThis study enrolled 16,839 participants with no history of alcohol consumption and no fatty liver disease in 2010. All participants completed a survey which included health and lifestyle questionnaires, and underwent physical examination, ultrasonography, and laboratory examinations of blood samples. After the four-year follow up, 5,104 (30.31%) participants were diagnosed with NAFLD. The associations between SUA, BMI or obesity, and incident NAFLD were assessed by multivariate linear regression, logistic regression analysis, and mediation analysis, respectively.ResultsBy adjusting demographic and serum characteristics, linear correlation coefficients between obesity and SUA were 20.26 [95% confidence interval (CI)]: 15.74, 24.77), 13.31 (95% CI: 6.63, 19.99) and 22.21 (95% CI: 16.41, 28.02) in the total population, and in the female and male groups, respectively. The odds ratios were 2.49 (95% CI: 1.61, 3.87) in the total population, 5.71 (95% CI: 2.25, 14.45) in the female group and 1.99 (95% CI: 1.15, 3.45) in the male group for the correlation between obesity and incident NAFLD. The mediation analysis showed that SUA contributed to 10.03%, 0.58%, and 12.54% of obesity-related NAFLD development in the total population, females and males, respectively.ConclusionThe findings showed mediation linkages of both obesity and SUA with the incident NAFLD. The role of SUA as a mediator constitutes clinical significance that should be recognized and considered.

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Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men

Metabolism ◽

10.1016/j.metabol.2010.08.005 ◽

2011 ◽

Vol 60 (6) ◽

pp. 860-866 ◽

Cited By ~ 54

Author(s):

Seungho Ryu ◽

Yoosoo Chang ◽

Soo-Geun Kim ◽

Juhee Cho ◽

Eliseo Guallar

Keyword(s):

Uric Acid ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Serum Uric Acid ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver

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Association of the Serum Uric Acid-to-Creatinine Ratio with Nonalcoholic Fatty Liver Disease Diagnosed by Computed Tomography

Metabolic Syndrome and Related Disorders ◽

10.1089/met.2020.0086 ◽

2020 ◽

Author(s):

Yoo Bin Seo ◽

A Lum Han

Keyword(s):

Computed Tomography ◽

Uric Acid ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Serum Uric Acid ◽

Fatty Liver Disease ◽

Creatinine Ratio ◽

Nonalcoholic Fatty Liver

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Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults

International Journal of Endocrinology ◽

10.1155/2020/5953461 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Ya-Nan Zhang ◽

Qin-Qiu Wang ◽

Yi-Shu Chen ◽

Chao Shen ◽

Cheng-Fu Xu

Keyword(s):

Uric Acid ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Serum Uric Acid ◽

Fatty Liver Disease ◽

Hdl Cholesterol ◽

Chinese Adults ◽

Nonalcoholic Fatty Liver ◽

Cholesterol Ratio

Background/Aim. The risk factors for nonalcoholic fatty liver disease (NAFLD) in lean population have not been fully clarified. This study aimed to explore the association between uric acid to HDL-cholesterol ratio (UHR) and NAFLD in lean Chinese adults. Methods. A cross-sectional study was performed among 6285 lean Chinese adults (body mass index < 24 kg/m2) who took their annual health checkups. NAFLD was diagnosed based on hepatic ultrasound examination, with exclusion of other etiologies. Results. Of 6285 lean participants enrolled, 654 NAFLD cases were diagnosed. The overall NAFLD prevalence was 10.41%, and the prevalence was 15.45% and 7.16% in men and women, respectively. UHR was significantly higher in NAFLD patients than in controls (14.25 ± 5.33% versus 10.09 ± 4.23%, P<0.001). UHR quintiles were positively associated with NAFLD prevalence, which was 1.91% in the first UHR quintile and increased to 3.58%, 7.81%, 14.17%, and 24.54% in the second, third, fourth, and fifth quintile groups, respectively (P<0.001 for trend). Multivariate logistic regression analysis showed that UHR was independently associated with an increased risk of NAFLD (odds ratio: 1.105; 95% CI: 1.076–1.134; P<0.001). Sensitivity analysis showed that UHR remained significantly associated with NAFLD in lean participants with normal range of serum uric acid and HDL-cholesterol levels. Conclusions. UHR was significantly associated with NAFLD and may serve as a novel and reliable marker for NAFLD in lean adults.

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Association between serum uric acid and nonalcoholic fatty liver disease

Journal of the Formosan Medical Association ◽

10.1016/j.jfma.2015.06.007 ◽

2016 ◽

Vol 115 (2) ◽

pp. 136 ◽

Cited By ~ 1

Author(s):

Mehmet Agilli ◽

Fevzi Nuri Aydin

Keyword(s):

Uric Acid ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Serum Uric Acid ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver

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Association between Serum Uric Acid to HDL-cholesterol Ratio and Nonalcoholic Fatty Liver Disease among Chinese Adults

10.21203/rs.3.rs-1025949/v1 ◽

2021 ◽

Author(s):

Hui Zhao ◽

Xia Qiu ◽

Jiajia Cui ◽

Yongye Sun

Keyword(s):

Uric Acid ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Serum Uric Acid ◽

Fatty Liver Disease ◽

Hdl Cholesterol ◽

Response Analysis ◽

Chinese Adults ◽

Nonalcoholic Fatty Liver

Abstract We conducted this case-control study to explore the association of serum uric acid (SUA) to HDL-cholesterol (HDL-C) ratio (UHR) with the risk of nonalcoholic fatty liver disease (NAFLD) in general Chinese adults. A total of 636 patients with NAFLD and 754 controls from affiliated hospital of Qingdao University in China between January to December 2016 were involved. NAFLD was diagnosed by ultrasonography after excluding other etiologies. The multivariable adjusted odds ratio and 95% confidence interval (CI) of NAFLD for the highest versus lowest quartile of UHR was 3.888 (2.324-6.504). In stratified analyses by sex and age, the positive associations between UHR and the risk of NAFLD were statistically significant in each subgroup. In stratified by BMI, the significant positive association was only found in the individuals with BMI≥23.9 kg/m2. Dose-response analysis indicated a linear positive correlation between UHR and NAFLD risk.

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