scholarly journals Prostate Volume has Prognostic Value Only in Pathologic T2 Radical Prostatectomy Specimens

2011 ◽  
Vol 26 (6) ◽  
pp. 807 ◽  
Author(s):  
In-Chang Cho ◽  
Whi-An Kwon ◽  
Jeong Eun Kim ◽  
Jae Young Joung ◽  
Ho Kyung Seo ◽  
...  
2007 ◽  
Vol 177 (4S) ◽  
pp. 340-340 ◽  
Author(s):  
Hong Gee Sim ◽  
Donatello Telesca ◽  
Stephen H. Culp ◽  
Paul H. Lange ◽  
William J. Ellis ◽  
...  

2013 ◽  
Vol 54 (4) ◽  
pp. 902 ◽  
Author(s):  
Mun Su Chung ◽  
Seung Hwan Lee ◽  
Dong Hoon Lee ◽  
Byung Ha Chung

2013 ◽  
Vol 7 (1-2) ◽  
pp. 93 ◽  
Author(s):  
Stavros Sfoungaristos ◽  
Petros Perimenis

Introduction: Preoperative Gleason score is crucial, in combination with other preoperative parameters, in selecting the appropriate treatment for patients with clinically localized prostate cancer. The aim of the present study is to determine the clinical and pathological variables that can predict differences in Gleason score between biopsy and radical prostatectomy.Methods: We retrospectively analyzed the medical records of 302 patients who had a radical prostatectomy between January 2005 and September 2010. The association between grade changes and preoperative Gleason score, age, prostate volume, prostate-specific antigen (PSA), PSA density, number of biopsy cores, presence of prostatitis and high-grade prostatic intraepithelial neoplasia was analyzed. We also conducted a secondary analysis of the factors that influence upgrading in patients with preoperative Gleason score ≤6 (group 1) and downgrading in patients with Gleason score ≤7 (group 2).Results: No difference in Gleason score was noted in 44.3% of patients, while a downgrade was noted in 13.7% and upgrade in 42.1%. About 2/3 of patients with a Gleason score of ≤6 upgraded after radical prostatectomy. PSA density (p = 0.008) and prostate volume (p = 0.032) were significantly correlated with upgrade. No significant predictors were found for patients with Gleason score ≤7 who downgraded postoperatively.Conclusion: Smaller prostate volume and higher values of PSA density are predictors for upgrade in patients with biopsy Gleason score ≤6 and this should be considered when deferred treatment modalities are planned.


2014 ◽  
Vol 8 (7-8) ◽  
pp. 476
Author(s):  
Olivier P. Heimrath ◽  
Zuzana Kos ◽  
Eric C. Belanger ◽  
Ilias Cagiannos ◽  
Chris Morash ◽  
...  

Introduction: We review a subset of men who had discordant prostate biopsy sums and were treated with radical prostatectomy.Methods: Consecutive patients treated with radical prostatectomy at The Ottawa Hospital between 2000 and 2012 were reviewed. Those with at least 1 prostate biopsy core of Gleason sum ≥8 and at least 1 prostate biopsy core of Gleason sum ≤7 cancer were included.Results: Of the 764 radical prostatectomies, 661 (87%) were eligible for the study and 35 (5%) met inclusion criteria. Of these, only 16 (46%) had prostatectomy Gleason sum of ≥8. When the highest biopsy core was Gleason sum 8 (n = 24), only 7 (29%) had a prostatectomy Gleason sum ≥8. When the highest biopsy core was Gleason 9 (n = 11), 9 (82%) had a prostatectomy Gleason sum ≥8 (relative risk [RR] 2.8; p = 0.004). Patients with clinical T3 tumours were at higher risk of Gleason sum ≥8 compared to cT1 patients (RR 3.7; p = 0.008). Patient age (p = 0.89), preoperative prostate-specific antigen (p = 0.34), prostate volume (p = 0.86), number of biopsy cores (p = 0.18), and proportion of biopsy cores with cancer (p = 0.96) were not strongly associated with risk of prostatectomy Gleason sum ≥8.Conclusion: These data should be considered when assigning patients into prognostic risk categories based on prostate biopsy information. Further study to verify our findings using larger samples is warranted.


2000 ◽  
Vol 1 (2) ◽  
pp. 110 ◽  
Author(s):  
Sung Bin Park ◽  
Jae Kyun Kim ◽  
Sung Hoon Choi ◽  
Han Na Noh ◽  
Eun Kyung Ji ◽  
...  

2000 ◽  
Vol 38 (5) ◽  
pp. 555-562 ◽  
Author(s):  
Sirpa Aaltomaa ◽  
Pertti Lipponen ◽  
Jouko Viitanen ◽  
Jussi-Pekka Kankkunen ◽  
Martti Ala-Opas ◽  
...  

2005 ◽  
Vol 4 (3) ◽  
pp. 117
Author(s):  
C. Chang ◽  
T. Gianduzzo ◽  
N. Tan ◽  
M. El-Shazly ◽  
D. Moon ◽  
...  

Urology ◽  
2007 ◽  
Vol 70 (4) ◽  
pp. 696-701 ◽  
Author(s):  
Phillip M. Pierorazio ◽  
Michael D. Kinnaman ◽  
Matthew S. Wosnitzer ◽  
Mitchell C. Benson ◽  
James M. McKiernan ◽  
...  

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