Immunohistochemical Study on Apoptosis and Cell Proliferation in the Lining Epithelium of Thyroglossal Duct Cysts.

Thyroglossal duct cysts are most common congenital anomalies in thyroid development and are usually presented with midline neck swelling. The co-existence of carcinoma in thyroglossal duct cyst’s is extremely rare. We, herein present a case of primary papillary carcinoma arising from thyroglossal duct cyst in a 45 year old woman. DOI: http://dx.doi.org/10.3126/ajms.v6i1.9305 Asian Journal of Medical Sciences Vol.6(1) 2015 129-131

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Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

International Journal of Molecular Sciences ◽

10.3390/ijms21186516 ◽

2020 ◽

Vol 21 (18) ◽

pp. 6516

Author(s):

Elena E. Pakhomova ◽

Irina O. Smirnova

Keyword(s):

Cell Proliferation ◽

Clinical Efficacy ◽

Comparative Evaluation ◽

Proliferative Activity ◽

Immunohistochemical Study ◽

Platelet Rich Plasma ◽

Androgenetic Alopecia ◽

Hair Morphology ◽

Promising Treatment ◽

Cd34 Expression

Platelet-rich plasma (PRP) therapy has been considered as a promising treatment for androgenetic alopecia (AGA). The aim of the study was comparative evaluation of the clinical efficacy of PRP-therapy, minoxidil, and their combination in the treatment of men with AGA and to evaluate the effects of PRP on the proliferation of hair follicle (HF) cells in skin biopsy. Materials and Methods: The study involved 69 men who were divided into 3 groups who received PRP therapy, minoxidil, and their combination. The clinical efficacy of the therapy was evaluated by the dynamics of morphometric of hairs. To assess cell proliferation antibodies to β-catenin, CD34, Ki67, and to Dkk-1 were used. Results. PRP treatment was more effective than minoxidil therapy (p = 0.005). Complex therapy turned out to be more effective than minoxidil monotherapy (p < 0.0001) and PRP monotherapy (p = 0.007). After applying PRP the absolute and relative values of the β-catenin and CD34 expression area increased; an increase in Ki67+ index was also significant. Conclusions: PRP can be considered as a treatment option for AGA. Combined PRP and minoxidil use seems promising for the treatment of AGA. PRP increase in the proliferative activity of HF cells and improves hair morphology in patients with AGA.

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Thyroglossal duct cysts and obstructive sleep apnoea: three case reports and review of the literature

The Journal of Laryngology & Otology ◽

10.1017/s0022215114001509 ◽

2014 ◽

Vol 128 (8) ◽

pp. 738-741 ◽

Cited By ~ 3

Author(s):

F Safiruddin ◽

D L Mourits ◽

N de Vries

Keyword(s):

Obstructive Sleep Apnoea ◽

Case Reports ◽

Sleep Apnoea ◽

Thyroglossal Duct Cyst ◽

Duct Cyst ◽

Thyroglossal Duct ◽

First Case ◽

Obstructive Sleep ◽

Thyroglossal Duct Cysts

AbstractBackground:Thyroglossal duct cysts and obstructive sleep apnoea are commonly occurring medical conditions which appear to present independently in patients. However, we noted three cases where the thyroglossal duct cysts influenced the development and/or therapy of obstructive sleep apnoea. In this article, these three case studies are presented, as is a study of the association between thyroglossal duct cysts and obstructive sleep apnoea, preceded by a literature review.Case reports:The patient in the first case study underwent hyoidthyroidpexia for obstructive sleep apnoea, which revealed an unexpected thyroglossal duct cyst. The second patient had previously undergone Sistrunk surgery for the removal of a thyroglossal duct cyst and subsequently presented with obstructive sleep apnoea. Finally, the third patient, who had previously undergone Sistrunk surgery, presented with obstructive sleep apnoea and underwent alternative surgery as hyoidthyroidpexia was no longer possible.Conclusion:To our knowledge, the association between thyroglossal duct cysts and obstructive sleep apnoea has not been addressed previously. The results indicate that the relationship is much stronger than previously thought, and further research is required to investigate the extent of the association and possible causal relations.

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Pericoronal Follicles of Asymptomatic Impacted Teeth: A Radiographic, Histomorphologic, and Immunohistochemical Study

International Journal of Dentistry ◽

10.1155/2012/935310 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 6

Author(s):

Laura Villalba ◽

Federico Stolbizer ◽

Fabián Blasco ◽

Néstor Raúl Mauriño ◽

María Julia Piloni ◽

...

Keyword(s):

Cell Proliferation ◽

Immunohistochemical Study ◽

Squamous Metaplasia ◽

Ki 67 ◽

Impacted Teeth ◽

Positive Expression ◽

Dentigerous Cysts ◽

Proliferation And Apoptosis ◽

Enamel Epithelium ◽

Reduced Enamel Epithelium

Objective. To associate radiographic and histopathological features of pericoronal follicles (PFs) of asymptomatic impacted teeth and evaluate cell proliferation and apoptosis in the epithelium.Study Design. Epithelium and mesenchyme of radiographically normal (NPF≤2.5 mm) and hyperplastic (HPF 2.6 to 5 mm) PF (n=140) were studied histologically. Cell proliferation (PI) and epithelial apoptosis were evaluated by Ki-67 and bcl-2 expression in 14 NPFs and 10 dentigerous cysts (DCs).Results. Radiographically, 127 were NPFs and 13 were HPFs; 87.8% of total PFs exhibited epithelium on the surface. Reduced enamel epithelium was observed in 78 (61.4%) NPFs and 6 (46.2%) HPFs, squamous metaplasia in 17 (13.4%) NPFs and 4 (30.8%) HPFs, and cystic epithelium in 15 (11.8%) NPFs and 3 (23%) HPFs. Mean PI was1.97±1.25and7.97±1.74in the epithelial component of NPF and DC, respectively; bcl-2 positive expression was observed in 9 (64.3%) NPFs and 7 (70%) DCs.Conclusion. The scant epithelial remnant proliferation could imply low risk for development of odontogenic pathologies in the absence of an additional stimulus.

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Prevalence of Thyroglossal Duct Cyst Carcinoma in Adults Having Surgery for Thyroglossal Duct Cysts

Thyroid ◽

10.1089/thy.2012-0182 ◽

2012 ◽

pp. 120724095458008

Author(s):

Giacomo Sturniolo ◽

Mariacarla Moleti ◽

Maria Antonia Violi ◽

Beatrice Di Bella ◽

Silvia Presti ◽

...

Keyword(s):

Thyroglossal Duct Cyst ◽

Duct Cyst ◽

Thyroglossal Duct ◽

Thyroglossal Duct Cysts

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A familial pattern of thyroglossal duct cysts

JAMA ◽

10.1001/jama.244.15.1714 ◽

1980 ◽

Vol 244 (15) ◽

pp. 1714-1714 ◽

Cited By ~ 1

Author(s):

J. S. Millikan

Keyword(s):

Thyroglossal Duct ◽

Thyroglossal Duct Cysts ◽

Familial Pattern

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Thyroglossal duct cyst anterior to the sternum: a novel presentation of a common lesion

BMJ Case Reports ◽

10.1136/bcr-2020-236515 ◽

2020 ◽

Vol 13 (11) ◽

pp. e236515

Author(s):

Jordan Whitney Rawl ◽

Nicholas Armando Rossi ◽

Matthew G Yantis ◽

Wasyl Szeremeta

Keyword(s):

Hyoid Bone ◽

Neck Mass ◽

Thyroglossal Duct Cyst ◽

Tongue Protrusion ◽

Duct Cyst ◽

Thyroglossal Duct ◽

Neck Masses ◽

Close Proximity ◽

Sistrunk Procedure ◽

Thyroglossal Duct Cysts

Thyroglossal duct cysts (TDCs) arise in roughly 7% of the general population and are typically diagnosed in childhood within the first decade of life. Typically, patients present with a painless, midline neck mass in close proximity to the hyoid bone which classically elevates with deglutition and tongue protrusion. We present a case of TDC found anterior to the sternum, a major deviation from the classical understanding of this lesion. The patient was treated successfully with modified Sistrunk procedure. This case underscores the need for clinicians to maintain a wide differential while working up paediatric patients presenting with neck masses. Furthermore, we emphasise that TDC must always be considered in cases of midline paediatric neck masses, even when found in unusual locations such as presented here.

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Simultaneous occurrence of a thyroglossal duct cyst and a lingual thyroid in the absence of an orthotopic thyroid gland

The Journal of Laryngology & Otology ◽

10.1017/s0022215111002970 ◽

2011 ◽

Vol 126 (2) ◽

pp. 217-220 ◽

Cited By ~ 3

Author(s):

J Madana ◽

R Kalaiarasi ◽

D Yolmo ◽

S Gopalakrishnan

Keyword(s):

Thyroid Gland ◽

English Language ◽

Thyroid Tissue ◽

Clinical Findings ◽

Thyroglossal Duct Cyst ◽

Simultaneous Occurrence ◽

Lingual Thyroid ◽

Duct Cyst ◽

Thyroglossal Duct ◽

Thyroglossal Duct Cysts

AbstractObjective:We report an extremely rare case of the simultaneous occurrence of a thyroglossal duct cyst and a lingual thyroid in the absence of an orthotopic thyroid gland, in a seven-year-old girl from South India.Method:Case report and a review of the English language literature on the subject.Results:The patient presented with a mass on the tongue that had been present for three years, and an anterior neck swelling that had been present for two years. Examination revealed a midline, pinkish, firm mass present on the posterior one-third of the tongue. The neck showed a midline cystic swelling in the infrahyoid position. Radiological imaging confirmed the clinical findings, revealing the absence of her thyroid gland in the normal location. Sistrunk's procedure was performed leaving behind a lingual thyroid. At 13-month follow up, the patient was euthyroid with no recurrence.Conclusion:To our knowledge the association of a lingual thyroid and a thyroglossal cyst has only been reported once in the literature. The presence of a lingual thyroid in the absence of a normally located thyroid gland or functioning thyroid tissue along the thyroglossal tract, confirmed by radionuclide and computed tomography imaging, may indicate the failure of the normal descent of the thyroid gland during embryonic development. This probable absence of the descent of the thyroid raises questions regarding the origin of thyroglossal duct cysts.

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