Genetic susceptibility to type 1 diabetes mellitus in humans

Immune Mediated ◽

Insulin Dependent ◽

Genetically Determined

Type 1 diabetes mellitus (DM 1A) is an autoimmune disease belonging to the most frequent chronic diseases of the childhood and young adults. DM 1A results from immune-mediated destruction of the insulin-producing beta cells of the pancreas. It is a genetically determined disease and many genes or genetic regions were found to be associated with its induction. In addition to the insulin-dependent diabetes mellitus 1 (IDDM1) gene, which marks the HLA region, and IDDM2 which marks the insulin gene, significant associations of DM 1A to other IDMM genes or genetic regions we reported. We shortly review recent achievements in the field, and the state of current knowledge.

Inhibition of Cytokine-Induced β Cell Apoptosis via Laccase and Its Therapeutic Advantages for Insulin-Dependent Diabetes Mellitus, Type 1 Diabetes

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.33.1854 ◽

2010 ◽

Vol 33 (11) ◽

pp. 1854-1860 ◽

Cited By ~ 6

Author(s):

Seong Soo Joo ◽

Do Ik Lee ◽

Kwang Woo Hwang

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Cell Apoptosis ◽

Diabetes Mellitus Type 1 ◽

Insulin Dependent Diabetes ◽

Β Cell ◽

Insulin Dependent

Insulin-Dependent Diabetes Mellitus, Myasthenia Gravis, Pernicious Anaemia, Autoimmune Thyroiditis and Autoimmune Adrenalitis in a Single Patient

Scottish Medical Journal ◽

10.1177/003693308803300112 ◽

1988 ◽

Vol 33 (1) ◽

pp. 213-214 ◽

Cited By ~ 2

Author(s):

S. T. Green ◽

J. P. Ng ◽

D. Chan-Lam

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Myasthenia Gravis ◽

Type 1 Diabetes Mellitus ◽

Pernicious Anaemia ◽

Autoimmune Conditions

Two classical autoimmune polyendocrine deficiency syndromes with heritable tendencies are described, Type 1 diabetes mellitus being associated with the Type 2 polyendocrine deficiency syndrome (Schmidt's syndrome). A man with Type 1 diabetes mellitus is described who developed an unusual combination of five autoimmune conditions (myasthenia gravis, Addisonian pernicious anaemia, adrenalitis and thyroiditis) which did not fit into the Type 1 or Type 2 classical polyendocrine deficiency syndromes. This suggests that the autoantibody, biochemical and haematological screening of affected individuals and their relatives should be extended to anticipate a wider range of potential autoimmune conditions.

Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)

American Journal of Clinical Nutrition ◽

10.3945/ajcn.110.000711 ◽

2011 ◽

Vol 94 (suppl_6) ◽

pp. 1814S-1820S ◽

Cited By ~ 38

Author(s):

◽

Mikael Knip ◽

Suvi M Virtanen ◽

Dorothy Becker ◽

John Dupré ◽

...

Keyword(s):

Diabetes Mellitus ◽

At Risk ◽

Type 1 Diabetes ◽

Insulin Dependent Diabetes ◽

Early Feeding ◽

Insulin Dependent

Pathological changes in the pancreas of fulminant type 1 diabetes and slowly progressive insulin-dependent diabetes mellitus (SPIDDM): innate immunity in fulminant type 1 diabetes and SPIDDM

Diabetes/Metabolism Research and Reviews ◽

10.1002/dmrr.1237 ◽

2011 ◽

Vol 27 (8) ◽

pp. 965-970 ◽

Cited By ~ 16

Author(s):

Tetsuro Kobayashi ◽

Yoriko Nishida ◽

Shoichiro Tanaka ◽

Kaoru Aida

Keyword(s):

Diabetes Mellitus ◽

Innate Immunity ◽

Type 1 Diabetes ◽

Pathological Changes ◽

Fulminant Type 1 Diabetes ◽

Insulin Dependent ◽

Fulminant Type

Analysis of the quality of primary health pare rendered to patients with type 1 diabetes mellitus

Problems of Endocrinology ◽

10.14341/probl12005 ◽

1994 ◽

Vol 40 (3) ◽

pp. 19-22 ◽

Cited By ~ 1

Author(s):

M. B. Antsiferov ◽

E. G. Starostina ◽

G. R. Galstyan ◽

I. I. Dedov

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Primary Health ◽

Long Duration ◽

Insulin Dependent ◽

Medical Recommendations

A prospective follow-up of a random sample of patients with insulin-dependent diabetes mellitus revealed a marked decompensation of carbohydrate metabolism in 98% of the examinees, a high incidence of diabetic ketoacidosis, a long duration of temporary invalidity, and poor adherence of patients to medical recommendations. Assessment of primary health care rendered to patients with type 1 diabetes at district outpatient clinics of Moscow demonstrated its poor efficacy and a necessity to improve the level of specialized diabetologic care.