scholarly journals Adiponectin as a potential marker of prostate cancer progression: studies in organ-confined and locally advanced prostate cancer

2008 ◽  
pp. 451-458
Author(s):  
D Housa ◽  
Z Vernerová ◽  
J Heráček ◽  
B Procházka ◽  
P Čechák ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Cancer Progression ◽  
Clinical Stage ◽  
Locally Advanced ◽  
Intraepithelial Neoplasia ◽  
Serum Levels ◽  
Prostatic Hyperplasia ◽  
Serum Adiponectin ◽  
Potential Marker

Serum levels of adiponectin were measured in patients with benign prostatic hyperplasia and prostate cancer of pT2 and pT3 stage. Adiponectin ELISA assay, immunohistochemistry, and selected metabolic and biochemical parameters measurement was performed in 25 patients with benign prostatic hyperplasia and 43 with prostate cancer (17 patients with organ-confined and 26 patients with locally advanced disease). Serum adiponectin levels did not differ between prostate benign hyperplasia and cancer clinical stage T2, but was significantly higher in pT3 relative to pT2 group (14.51±4.92 vs. 21.41±8.12, P = 0.003). Tissue immunohistochemistry showed enhanced staining in neoplastic prostate glands and intraepithelial neoplasia relative to benign prostatic hyperplasia without distinction between disease grade and stage. Serum adiponectin levels are higher in locally advanced relative to organ-confined prostate cancer and may thus serve as an auxiliary marker providing further improvement for discrimination between pT2 and pT3 stages.

Corrigendum to “Tissue and serum levels of principal androgens in benign prostatic hyperplasia and prostate cancer” [Steroids 72(4) (2007) 375–380]

Steroids ◽  
2008 ◽  
Vol 73 (1) ◽  
pp. 148 ◽  
Author(s):  
Jiri Heracek ◽  
Richard Hampl ◽  
Martin Hill ◽  
Luboslav Starka ◽  
Jana Sachova ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Serum Levels ◽  
Prostatic Hyperplasia

Serum Levels of Secreted Group IIA Phospholipase A2 in Benign Prostatic Hyperplasia and Prostate Cancer: A Biomarker for Inflammation or Neoplasia?

Inflammation ◽  
2011 ◽  
Vol 35 (3) ◽  
pp. 1113-1118 ◽  
Author(s):  
Mario Menschikowski ◽  
Albert Hagelgans ◽  
Susanne Fuessel ◽  
Olga A. Mareninova ◽  
Volker Neumeister ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Phospholipase A2 ◽  
Serum Levels ◽  
Prostatic Hyperplasia ◽  
Group Iia Phospholipase A2

scholarly journals Correlation of serum free prostate-specific antigen level with histological findings in patients with prostatic disease

1970 ◽  
Vol 8 (2) ◽  
pp. 158-163 ◽  
Author(s):  
M Lakhey ◽  
R Ghimire ◽  
R Shrestha ◽  
AD Bhatta
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Prostatic Hyperplasia ◽  
Free Form ◽  
High Grade ◽  
Prostatic Disease ◽  
Active Inflammation ◽  
The Relationship

Background: Prostate Specifi c Antigen (PSA) has been widely used in the diagnosis and management of patients with prostate cancer. It may be elevated in other prostatic diseases and surgical procedures. PSA exists in two forms, a major bound form (cPSA) and a free form (fPSA). Objectives: The objective of the study was to determine the relationship between serum fPSA levels and histologic findings in biopsy specimens of men with prostatic disease. Material and methods: This study includes 91 patients planned for transurethral resection of prostate (TURP). Blood samples were collected before TURP and tested for fPSA. Histology of the tissue samples collected after TURP were studied and the relationship with fPSA analysed using SPSS 11.5. Results: The median values for benign, premalignant and malignant lesions were 1.8ng/ml, 4.5ng/ml and 13.20ng/ml respectively (p<0.001). Most cases of benign prostatic hyperplasia(BPH) without inflammation had fPSA levels <2ng/ ml, while most with active inflammation had levels >5ng/ml. Low grade prostatic intraepithelial neoplasia (LGPIN) saw levels <5ng/ml while high grade intraepithelial neoplasia (HGPIN) and prostate cancer (PCa) had levels > 5ng/mL (p<0.05). For detection of high grade lesions (HGPIN and PCa), the sensitivity and specificity of fPSA level > 5ng/ml was found to be 88.8% and 90.2% respectively. Conclusions: Serum fPSA is elevated marginally in patients with BPH without inflammation. Active inflammation and high grade lesions are associated with fPSA level more than 5 ng/ml. Key words: Benign prostatic hyperplasia; fPSA; prostate cancer; prostatic intraepithelial neoplasia. DOI: 10.3126/kumj.v8i2.3550 Kathmandu University Medical Journal (2010), Vol. 8, No. 2, Issue 30, 158-163  

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