scholarly journals Chronic atropine administration diminishes the contribution of vasoactive intestinal polypeptide to heart rate regulation

2008 ◽  
pp. 827-837
Author(s):  
J Kuncová ◽  
Š Faitová ◽  
J Capouch ◽  
M Štengl ◽  
J Slavíková
Keyword(s):  
Heart Rate ◽  
Single Dose ◽  
Vasoactive Intestinal Polypeptide ◽  
Rat Heart ◽  
Vagal Stimulation ◽  
Rate Regulation ◽  
Heart Rate Regulation ◽  
The Impact ◽  
Heart Atria ◽  
Intestinal Polypeptide

Vasoactive intestinal polypeptide (VIP) is implicated in the modulation of vagal effects on the heart rate. In this study, the impact of acute and chronic atropine administration on VIP levels in rat heart atria was investigated in relation to heart rate in the course of vagus nerves stimulation. Anaesthetised control and atropinised (10 mg/kg/day for 10 days) rats pretreated with metipranolol and phentolamine that were either given or not a single dose of atropine were subjected to bilateral vagus nerve stimulation (30 min: 0.7 mA, 20 Hz, 0.2 ms). VIP concentrations in the atria were determined after each stimulation protocol. In control rats with or without single atropine administration, the heart rate upon vagal stimulation was higher than in atropinised animals with or without single atropine dose, respectively. VIP concentrations in the control atria were significantly decreased after the stimulation; the decrease was comparable both in the absence and presence of a single dose of atropine. Compared to controls, VIP levels were significantly decreased after chronic atropine treatment and they were not further reduced by vagal stimulation and single atropine administration. Administration of VIP antagonist completely abolished the differences in the heart rate upon vagal stimulation between control and atropinised groups. In conclusion, the data indicate that chronic atropine administration affects VIP synthesis in rat heart atria and consequently it modifies the heart rate regulation.

Central benzodiazepine involvement in clonidine cardiovascular actions

1999 ◽  
Vol 77 (11) ◽  
pp. 844-851 ◽  
Author(s):  
José Luis Castro ◽  
Daniel Ricci ◽  
Carlos Alberto Taira ◽  
Agustín Ramirez
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Vagal Stimulation ◽  
Benzodiazepine Receptor ◽  
Mean Blood Pressure ◽  
Rate Regulation ◽  
Heart Rate Regulation ◽  
Channel Opening ◽  
Benzodiazepine Receptor Agonist ◽  
Prior Administration

It is well known that the GABAergic and noradrenergic systems play an important role in blood pressure and heart rate regulation. Benzodiazepines and beta-carbolines, respectively, increase or decrease the probability of chloride-channel opening induced by GABA. The aim of this study was to determine, in conscious rats, the interaction existing between the central alpha2-adrenoceptor stimulation induced by clonidine and the facilitation or impairment of benzodiazepine receptor activity through the administration of either diazepam, a benzodiazepine receptor agonist, or methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), an inverse benzodiazepine agonist. Clonidine (5-10 µg, intracerebroventricularly) reduced heart rate and increased mean blood pressure by activation of central alpha2-adrenoceptors. Diazepam (2 mg/kg, intravenously (i.v.)) induced an increase in heart rate, while DMCM (0.3 mg/kg, i.v.) elicited a bradycardic effect. The bradycardic effects induced by both clonidine and DMCM were antagonized by the prior administration of methylatropine (1.5 mg/kg, i.v.). DMCM (0.3 mg/kg, i.v.) prevented the clonidine effects on heart rate and mean blood pressure, while diazepam (2 mg/kg, i.v.) failed to modify these effects. Our results suggest that the bradycardic effects of clonidine are mediated by a vagal stimulation and are related to the activation of a GABAergic pathway.Key words: blood pressure, clonidine, diazepam, methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), heart rate.

Heart Rate Regulation During Exercise with Various Loads: Identification and Nonlinear H∞ Control

2008 ◽  
Vol 41 (2) ◽  
pp. 11618-11623 ◽  
Author(s):  
Teddy M. Cheng ◽  
Andrey V. Savkin ◽  
Branko G. Celler ◽  
Steven W. Su ◽  
Lu Wang
Keyword(s):  
Heart Rate ◽  
Rate Regulation ◽  
Heart Rate Regulation

Reduced capacity of heart rate regulation in response to mild hypoglycemia induced by glibenclamide and physical exercise in type 2 diabetes

Metabolism ◽  
2013 ◽  
Vol 62 (5) ◽  
pp. 717-724 ◽  
Author(s):  
Nedim Soydan ◽  
Reinhard G. Bretzel ◽  
Britta Fischer ◽  
Florian Wagenlehner ◽  
Adrian Pilatz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Heart Rate ◽  
Physical Exercise ◽  
Rate Regulation ◽  
Heart Rate Regulation

scholarly journals Features of heart rate variability in patients with takotsubo syndrome

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
D Evdokimov ◽  
SA Boldueva ◽  
VS Feoktistova ◽  
TA Baeva
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sinus Rhythm ◽  
Autonomic Regulation ◽  
Deep Breathing ◽  
Takotsubo Syndrome ◽  
Orthostatic Test ◽  
Rate Regulation ◽  
Heart Rate Regulation ◽  
Deep Breathing Test

Abstract Funding Acknowledgements Type of funding sources: None. Main funding source(s): North-Western State Medical University named after I.I. Mechnikov Objective to study the features of autonomic regulation of sinus rhythm features of autonomic regulation of cardiac sinus rhythm in patients with Takotsubo syndrome (TTS) during inpatient stay in hospital. Materials and methods. The study included 25 female patients (the median age 57.5 ± 28.5 years) with TTS, diagnosis was based on the InterTAK criteria. On the 5-7th day after admission, the heart rate variability (HRV) was assessed both at rest and cardiac autonomic function tests: the deep breathing test (DBT) and active orthostatic test (AOT) with the usage of a computer diagnostic system «Valenta». RESULTS According to HRV data, initially at rest, the majority of the studied patients predominantly had a parasympathetic impact on the heart rate regulation: in 70% - increased parasympathetic influence, in 17% - increased sympathetic influence, in 13% - a balanced heart rate regulation. When performing a DBT, the predominance of the parasympathetic influence on the heart rate was noted both in spectral parameters and according to the data of time analysis (HF  during DBT  increased 1.8 times  up to  489.6 ± 114.2 ms2 (p <0.05) ; LF  decreased 1.7 times  up to 254.1 ± 70.3 ms2 (p <0.05); VLF  increased 2.8 times up to 402.3 ± 101.8 ms2 (p <0, 05); TP  increased 1.4 times up to 1145.9 ± 251.3 ms2; CV increased 1.3 times up to 6.5 ± 0.7% (p <0.05); SDNN increased 1.3 times up to - 58.7 ± 6.6 ms (p <0.05). HRV measured during an AOT  showed a paradoxical  evaluation  in the parasympathetic impact on the heart rate (HF increased by 1.8 times and reached - 488.0 ± 104.7 ms2 (p <0.05); LF decreased by 1.1 times up to  408 , 4 ± 103.6 ms2; VLF increased 1.2 times  up to  166.4 ± 52.2 ms2; TP increased 1.3 times  up to 1062.8 ± 181.1 ms2 (p <0.05); CV increased 1.6 times  up to 8.0 ± 0.9% (p <0.05); SDNN increased 1.4 times  up to 62.6 ± 7.5 ms (p <0.05)). Conclusions During the index hospital inpatient stays the majority of patients with TTS have a vegetative imbalance due to increased parasympathetic influence on the heart rate, both at rest and  during a deep breathing test and an active orthostatic test. This fact is quite unexpected and requires further study.

Implementation of RSA-BFB Therapy in Students with Various Types of Autonomic Heart Rate Regulation in the Process of Adaptation to Learning Activity

2020 ◽  
Vol 46 (6) ◽  
pp. 663-670
Author(s):  
P. U. Zarchenko ◽  
E. M. Kazin ◽  
N. G. Blinova ◽  
L. A. Varich ◽  
I. L. Vasilchenko
Keyword(s):  
Heart Rate ◽  
Learning Activity ◽  
Rate Regulation ◽  
Heart Rate Regulation

scholarly journals β3 Adrenergic Receptors in the Sinoatrial Node for Heart Rate Regulation

2021 ◽  
Vol 16 ◽  
Author(s):  
Shu Nakao ◽  
Kazuki Yanagisawa ◽  
Tomoe Ueyama ◽  
Koji Hasegawa ◽  
Teruhisa Kawamura
Keyword(s):  
Heart Rate ◽  
Adrenergic Receptors ◽  
Sinoatrial Node ◽  
Rate Regulation ◽  
Heart Rate Regulation
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