scholarly journals β3 Adrenergic Receptors in the Sinoatrial Node for Heart Rate Regulation

2021 ◽  
Vol 16 ◽  
Author(s):  
Shu Nakao ◽  
Kazuki Yanagisawa ◽  
Tomoe Ueyama ◽  
Koji Hasegawa ◽  
Teruhisa Kawamura
2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Carlo Cifelli ◽  
Hangjun Zhang ◽  
Robert Alan Rose ◽  
Peter Backx ◽  
Scott Heximer

2008 ◽  
Vol 41 (2) ◽  
pp. 11618-11623 ◽  
Author(s):  
Teddy M. Cheng ◽  
Andrey V. Savkin ◽  
Branko G. Celler ◽  
Steven W. Su ◽  
Lu Wang

Metabolism ◽  
2013 ◽  
Vol 62 (5) ◽  
pp. 717-724 ◽  
Author(s):  
Nedim Soydan ◽  
Reinhard G. Bretzel ◽  
Britta Fischer ◽  
Florian Wagenlehner ◽  
Adrian Pilatz ◽  
...  

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
D Evdokimov ◽  
SA Boldueva ◽  
VS Feoktistova ◽  
TA Baeva

Abstract Funding Acknowledgements Type of funding sources: None. Main funding source(s): North-Western State Medical University named after I.I. Mechnikov Objective to study the features of autonomic regulation of sinus rhythm features of autonomic regulation of cardiac sinus rhythm in patients with Takotsubo syndrome (TTS) during inpatient stay in hospital. Materials and methods. The study included 25 female patients (the median age 57.5 ± 28.5 years) with TTS, diagnosis was based on the InterTAK criteria. On the 5-7th day after admission, the heart rate variability (HRV) was assessed both at rest and cardiac autonomic function tests: the deep breathing test (DBT) and active orthostatic test (AOT) with the usage of a computer diagnostic system «Valenta». RESULTS According to HRV data, initially at rest, the majority of the studied patients predominantly had a parasympathetic impact on the heart rate regulation: in 70% - increased parasympathetic influence, in 17% - increased sympathetic influence, in 13% - a balanced heart rate regulation. When performing a DBT, the predominance of the parasympathetic influence on the heart rate was noted both in spectral parameters and according to the data of time analysis (HF  during DBT  increased 1.8 times  up to  489.6 ± 114.2 ms2 (p <0.05) ; LF  decreased 1.7 times  up to 254.1 ± 70.3 ms2 (p <0.05); VLF  increased 2.8 times up to 402.3 ± 101.8 ms2 (p <0, 05); TP  increased 1.4 times up to 1145.9 ± 251.3 ms2; CV increased 1.3 times up to 6.5 ± 0.7% (p <0.05); SDNN increased 1.3 times up to - 58.7 ± 6.6 ms (p <0.05). HRV measured during an AOT  showed a paradoxical  evaluation  in the parasympathetic impact on the heart rate (HF increased by 1.8 times and reached - 488.0 ± 104.7 ms2 (p <0.05); LF decreased by 1.1 times up to  408 , 4 ± 103.6 ms2; VLF increased 1.2 times  up to  166.4 ± 52.2 ms2; TP increased 1.3 times  up to 1062.8 ± 181.1 ms2 (p <0.05); CV increased 1.6 times  up to 8.0 ± 0.9% (p <0.05); SDNN increased 1.4 times  up to 62.6 ± 7.5 ms (p <0.05)). Conclusions During the index hospital inpatient stays the majority of patients with TTS have a vegetative imbalance due to increased parasympathetic influence on the heart rate, both at rest and  during a deep breathing test and an active orthostatic test. This fact is quite unexpected and requires further study.


2020 ◽  
Vol 46 (6) ◽  
pp. 663-670
Author(s):  
P. U. Zarchenko ◽  
E. M. Kazin ◽  
N. G. Blinova ◽  
L. A. Varich ◽  
I. L. Vasilchenko

2008 ◽  
pp. 827-837
Author(s):  
J Kuncová ◽  
Š Faitová ◽  
J Capouch ◽  
M Štengl ◽  
J Slavíková

Vasoactive intestinal polypeptide (VIP) is implicated in the modulation of vagal effects on the heart rate. In this study, the impact of acute and chronic atropine administration on VIP levels in rat heart atria was investigated in relation to heart rate in the course of vagus nerves stimulation. Anaesthetised control and atropinised (10 mg/kg/day for 10 days) rats pretreated with metipranolol and phentolamine that were either given or not a single dose of atropine were subjected to bilateral vagus nerve stimulation (30 min: 0.7 mA, 20 Hz, 0.2 ms). VIP concentrations in the atria were determined after each stimulation protocol. In control rats with or without single atropine administration, the heart rate upon vagal stimulation was higher than in atropinised animals with or without single atropine dose, respectively. VIP concentrations in the control atria were significantly decreased after the stimulation; the decrease was comparable both in the absence and presence of a single dose of atropine. Compared to controls, VIP levels were significantly decreased after chronic atropine treatment and they were not further reduced by vagal stimulation and single atropine administration. Administration of VIP antagonist completely abolished the differences in the heart rate upon vagal stimulation between control and atropinised groups. In conclusion, the data indicate that chronic atropine administration affects VIP synthesis in rat heart atria and consequently it modifies the heart rate regulation.


2021 ◽  
Vol 6 (5) ◽  
pp. 456-464
Author(s):  
A. P. Romanchuk ◽  
◽  
O. V. Guzii ◽  
A. V. Maglyovanyi ◽  
◽  
...  

The purpose of the study was a comparative analysis of sensorimotor reactions in highly trained athletes with different types of heart rate regulation. Materials and methods. 202 highly trained male athletes aged 22.6±2.8 years, who are engaged in acyclic sports – martial arts (karate, taekwondo, kickboxing, boxing, freestyle wrestling, Greco-Roman wrestling, judo, sambo) and games (water polo, soccer) were examined. The experience in sports was 10.3±3.1 years. All studies were conducted in the pre-competition period in the morning. Based on the study of heart rate variability in athletes, the type of heart rate regulation was determined. The basis for determining the types of regulation is the classification of heart rate variability indicators, taking into account their inclusion in certain limits. Heart rate variability indicators that reflect the dual-circuit model of heart rate regulation and are used for diagnosis include: total heart rate variability – total power (ms2), very low frequency (ms2), and stress-index (e.u.), which reflect the various chains of regulatory effects on heart rate. According to certain data types, 4 groups were formed. 1 group (type I) consisted of 42 athletes, 2 (type II) – 28 athletes, 3 (type III) – 88 athletes, 4 (type IV) – 44 athletes. The study of sensorimotor function was performed using the device KMM-3. Results and discussion. It is shown that the most balanced sensorimotor reactions are in athletes with type III regulation of heart rate. The most strain sensorimotor reactions are observed in type II regulation of heart rate, which is reflected in the pronounced central asymmetry of movement control with acceleration to the left against the background of deteriorating accuracy of right (due to flexors) and left (due to extensors) limbs, and the right-hand predominance. Sensorimotor reactions are quite strain in type IV of heart rate regulation, which is characterized by slow reactions at the synaptic and peripheral levels. In type I of heart rate regulation, the disorders observed at the central level of regulation relate to the asymmetry of short-term motor memory processes, which are significantly reduced in the left hemisphere. Conclusion. The study shows that the differences in the regulatory support of heart rate in highly qualified athletes are accompanied by characteristic differences in sensorimotor function. The latter can be useful for the diagnosis and further correction of conditions associated with the development of overexertion and overtraining


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