scholarly journals Homeostatic Modulation of Stimulation-Dependent Plasticity in Human Motor Cortex

2011 ◽  
pp. S107-S112 ◽  
Author(s):  
N. V. ILIĆ ◽  
S. MILANOVIĆ ◽  
J. KRSTIĆ ◽  
Đ. D. BAJEC ◽  
M. GRAJIĆ ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Motor Cortex ◽  
Motor Evoked Potential ◽  
Single Pair ◽  
Post Intervention ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Human Motor ◽  
Plastic Changes ◽  
Complex Relationships

Since recently, it is possible, using noninvasive cortical stimulation, such as the protocol of paired associative stimulation (PAS), to induce the plastic changes in the motor cortex, in humans that mimic Hebb's model of learning. Application of TMS conjugated with peripheral electrical stimulation at strictly coherent temporal manner lead to convergence of inputs in the sensory-motor cortex, with the consequent synaptic potentiation or weakening, if applied repetitively. However, when optimal interstimulus interval (ISI) for induction of LTP-like effects is applied as a single pair, Motor evoked potential (MEP) amplitude inhibition is observed, the paradigm known as short-latency afferent inhibition (SLAI). Aiming to resolve this paradox, PAS protocols were applied, with 200 repetitions of TMS pulses paired with median nerve electrical stimulation, at ISI equal to individual latencies of evoked response of somatosensory cortex (N20) (PASLTP), and at ISI of N20 shortened for 5 msec (PASLTD) – protocols that mimic LTP-like changes in the human motor cortex. MEP amplitudes before, during and after interventions were measured as an indicator based on output signals originating from the motor system. Post-intervention MEP amplitudes following the TMS protocols of PASLTP and PASLTD were facilitated and depressed, respectively, contrary to MEP amplitudes during intervention. During PASLTP MEP amplitudes were significantly decreased in case of PASLTP, while in the case of PASLTD an upward trend was observed. In conclusions, a possible explanation for the seemingly paradoxical effect of PAS can be found in the mechanism of homeostatic modulation of plasticity. Those findings indicate the existence of complex relationships in the development of plasticity induced by stimulation, depending on the level of the previous motor cortex excitability.

P025 Minocycline has acute inhibitory effects on human motor cortex excitability

2008 ◽  
Vol 119 ◽  
pp. S77
Author(s):  
Nicolas Lang ◽  
Daniella Terney ◽  
Holger Rothkegel ◽  
Andrea Antal ◽  
Walter Paulus
Keyword(s):  
Motor Cortex ◽  
Inhibitory Effects ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Human Motor

scholarly journals High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions

2022 ◽  
Vol 15 ◽  
Author(s):  
Ru Ma ◽  
Xinzhao Xia ◽  
Wei Zhang ◽  
Zhuo Lu ◽  
Qianying Wu ◽  
...  
Keyword(s):  
Reaction Time ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Reaction Time Task ◽  
Promoting Effect ◽  
Motor Functions ◽  
Human Motor Cortex ◽  
Time Task ◽  
Motor Cortex Excitability ◽  
Human Motor

Background: Temporal interference (TI) stimulation is a new technique of non-invasive brain stimulation. Envelope-modulated waveforms with two high-frequency carriers can activate neurons in target brain regions without stimulating the overlying cortex, which has been validated in mouse brains. However, whether TI stimulation can work on the human brain has not been elucidated.Objective: To assess the effectiveness of the envelope-modulated waveform of TI stimulation on the human primary motor cortex (M1).Methods: Participants attended three sessions of 30-min TI stimulation during a random reaction time task (RRTT) or a serial reaction time task (SRTT). Motor cortex excitability was measured before and after TI stimulation.Results: In the RRTT experiment, only 70 Hz TI stimulation had a promoting effect on the reaction time (RT) performance and excitability of the motor cortex compared to sham stimulation. Meanwhile, compared with the sham condition, only 20 Hz TI stimulation significantly facilitated motor learning in the SRTT experiment, which was significantly positively correlated with the increase in motor evoked potential.Conclusion: These results indicate that the envelope-modulated waveform of TI stimulation has a significant promoting effect on human motor functions, experimentally suggesting the effectiveness of TI stimulation in humans for the first time and paving the way for further explorations.

scholarly journals Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Anton Fomenko ◽  
Kai-Hsiang Stanley Chen ◽  
Jean-François Nankoo ◽  
James Saravanamuttu ◽  
Yanqiu Wang ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Short Interval ◽  
Motor Evoked Potential ◽  
Cortical Inhibition ◽  
Transcranial Ultrasound ◽  
Human Motor Cortex ◽  
Low Intensity ◽  
Visuomotor Task ◽  
Motor Cortex Excitability ◽  
And Behavior

Low-intensity transcranial ultrasound (TUS) can non-invasively modulate human neural activity. We investigated how different fundamental sonication parameters influence the effects of TUS on the motor cortex (M1) of 16 healthy subjects by probing cortico-cortical excitability and behavior. A low-intensity 500 kHz TUS transducer was coupled to a transcranial magnetic stimulation (TMS) coil. TMS was delivered 10 ms before the end of TUS to the left M1 hotspot of the first dorsal interosseous muscle. Varying acoustic parameters (pulse repetition frequency, duty cycle, and sonication duration) on motor-evoked potential amplitude were examined. Paired-pulse measures of cortical inhibition and facilitation, and performance on a visuomotor task was also assessed. TUS safely suppressed TMS-elicited motor cortical activity, with longer sonication durations and shorter duty cycles when delivered in a blocked paradigm. TUS increased GABAA-mediated short-interval intracortical inhibition and decreased reaction time on visuomotor task but not when controlled with TUS at near-somatosensory threshold intensity.

Influence of (S)-ketamine on human motor cortex excitability

2012 ◽  
Vol 225 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Oliver Höffken ◽  
Ida S. Haussleiter ◽  
Andrea Westermann ◽  
Jörn Lötsch ◽  
Christoph Maier ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Human Motor

Visual deprivation effects on human motor cortex excitability

2005 ◽  
Vol 389 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Fidias E. Leon-Sarmiento ◽  
William Bara-Jimenez ◽  
Eric M. Wassermann
Keyword(s):  
Motor Cortex ◽  
Visual Deprivation ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Human Motor

25. Minocycline has acute inhibitory effects on human motor cortex excitability

2009 ◽  
Vol 120 (1) ◽  
pp. e14-e15
Author(s):  
D. Terney ◽  
H. Rothkegel ◽  
A. Antal ◽  
W. Paulus ◽  
N. Lang
Keyword(s):  
Motor Cortex ◽  
Inhibitory Effects ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Human Motor

scholarly journals High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions

2021 ◽  
Author(s):  
Ru Ma ◽  
Xinzhao Xia ◽  
Wei Zhang ◽  
Zhuo Lu ◽  
Qianying Wu ◽  
...  
Keyword(s):  
Reaction Time ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Reaction Time Task ◽  
Promoting Effect ◽  
Motor Functions ◽  
Human Motor Cortex ◽  
Time Task ◽  
Motor Cortex Excitability ◽  
Human Motor

Temporal interference (TI) stimulation is a new technique of noninvasive brain stimulation. Envelope-modulated waveforms with two high-frequency carriers can activate neurons in target brain regions without stimulating the overlying cortex, which has been validated in mouse brains. However, whether TI stimulation can work on the human brain has not been elucidate. In this study, this issue is investigated in the human primary motor cortex. Participants attended three sessions of TI stimulation during a random reaction time task (RRTT) or a serial reaction time task (SRTT). Motor cortex excitability was measured before and after TI stimulation. The results indicate that TI stimulation with different envelope frequencies influenced different motor functions. In the RRTT experiment, only 70 Hz TI stimulation had a promoting effect on the reaction time performance and excitability of the motor cortex compared to sham stimulation. Meanwhile, compared with the sham condition, only 20 Hz TI stimulation significantly facilitated motor learning in the SRTT experiment, which was significantly positively correlated with the increase in motor evoked potential. These results indicate that the envelope-modulated waveform of TI stimulation has a significant promoting effect on human motor functions, experimentally suggesting the effectiveness of TI stimulation in humans for the first time.

Sign in / Sign up

Export Citation Format

Share Document