scholarly journals Study of microflora of oral cavity in men and women with gastroesophageal reflux disease

2019 ◽  
Vol 2 (11) ◽  
pp. 27-28
Author(s):  
I. M. Makeeva ◽  
E. G. Margaryan ◽  
L. S. Sazanskaya ◽  
M. M. Gulua

The number of men and women with gastroesophageal reflux disease (GERD) is increasing every year, in addition this disease tends to rejuvenation. Due to the fact that the oral cavity is the initial part of the digestive system, diseases of the gastrointestinal tract (GIT) and the corresponding changes in the oral cavity are closely interrelated. Objective: to determine the qualitative composition of the oral microflora in men and women with gastroesophageal reflux disease. Materials and methods. 20 patients (10 men and 10 women) aged 18 to 74 years with gastroesophageal reflux disease were examined. PCR (polymerase chain reaction) was used for the study, saliva pH and periodontal index PI were measured. Research result. A study of the microflora of the oral cavity showed a high prevalence of periodontopathogenic microorganisms Porpheromonas gingivalis and Prevotella intermidia, 65% of patients (45% men and 20% women), Actinobaccilus actinomecetemcomitans in 45% of patients (15% of men and 30% women), Treponema denticola in 80% of patients with GERD. It was dominated by the acidic environment. The data obtained indicate the relationship between the qualitative composition of the oral microflora and the progression of periodontal disease in men and women with gastroesophageal reflux disease.

2020 ◽  
pp. 5-8
Author(s):  
O.P. Kerzyuk ◽  
N.M. Rozhko ◽  
A.V. Kindrat

Nowadays, gastroesophageal reflux disease (GERD) is particularly relevant because it concerns many health and social issues. According to international and national statistics, the number of GERD patients is constantly increasing, especially among the socially active segments of the population. GERD is one of the most important problems of modern gastroenterology due to the increase in the number of patients with this pathology, the presence of both typical and atypical symptoms significantly impair the quality of patients’ life. Atypical symptoms of GERD may lead to overdiagnosis of some diseases and worsen their course; sometimes patients run the risk of developing serious complications with the need of long-term medical treatment in case of insufficient awareness of physicians about GERD. Increased attention should be given to issues of concomitant pathology of the oral cavity and diseases of the esophagus taking into account the anatomical proximity, the commonness of the blood supply, innervation and humoral regulation, because the mouth is the first division of the alimentary canal. Therefore, all GERD-associated changes in the oral cavity can be divided into change in soft tissues (the vermilion border, mucosa, tongue, periodontal tissues) and hard tissues of teeth and a deterioration of the content and quality of oral fluid. Our study aimed at examining the prevalence and variation of pathological changes in the oral mucosa of GERD patients. We examined 90 patients aged 25–35 years and 45–55 years. Patients were divided into 3 groups of 30 patients in each group: 1 group – patients with diagnosed GERD with high acidity; 2 group – patients with low acidity, 3 group – control. The patients have been examined by a gastroenterologist based on generally accepted criteria, esophageal pH monitoring data as well as fibrogastroduodenoscopy of esophagus and stomach. Dental assessment included evaluating the state of oral hygiene (index Green-Vermilion), and oral mucosa condition; the periodontal status was assessed by the index Rassel. In conclusion, the findings indicate a variety of changes in oral cavity in patients with GERD, both with high and with low acidity. The prospect of our further research will be to develop an algorithm for diagnosis and treatment of oral GERD manifestations and secondary dental disease prevention.


2016 ◽  
Vol 17 (11) ◽  
pp. 943-947 ◽  
Author(s):  
KMK Masthan ◽  
E Vinesh ◽  
M Sathish Kumar ◽  
S Marytresa Jeyapriya ◽  
Aravindha Babu ◽  
...  

ABSTRACT Objectives The aim and objectives of this study are to identify oral changes in certain gastrointestinal (GI) diseases, namely gastroesophageal reflux disease (GERD), ulcerative colitis, gastritis, and to evaluate these oral symptoms as indicators for assessing GI disorders. Materials and methods In this study, the oral manifestations of various GI disorders were assessed in a varying age group of 250 patients in Government Stanley Medical College and Hospital, Chennai. Out of 250 patients, 142 were affected by GERD, 99 were affected by gastritis, and 9 patients were affected by ulcerative colitis. Of these patients, 177 were males and 73 were females. Results Evaluation of patients with gastritis revealed that 66.7% affected with gingivitis, 19.2% with dental erosion on the palatal and lingual aspects of maxillary and mandibular teeth predominantly in the anterior region, 10.1% with periodontitis, 2% with gingival erythema. Among the patients with GERD, 44% of the cases showed dental erosion, 25.5% periodontitis, 9.9% gingivitis, 5.7% gingival erythema, 2.8% palatal erythema, 2.1% gingival ulcers, glossitis 2%, 1.4% floor of the mouth erythema, and 0.7% erythema of the tongue. Patients with ulcerative colitis showed 44.4% of gingival erythema, 33.3% of dental erosions, and 22.2% of gingival ulcers and periodontitis. Conclusion In our study of 250 patients, oral manifestations were observed in 88% of the patients. Both soft tissue and hard tissue changes were evident. There was a high correlation between various GI disease and dental erosion, erythema at various sites of the oral cavity, oral ulcers, gingivitis, periodontitis, and glossitis. Careful evaluation of oral cavity may unveil many GI disorders and help the patient by providing early diagnosis, which further facilitates the prognosis. How to cite this article Vinesh E, Masthan KMK, Kumar MS, Jeyapriya SM, Babu A, Thinakaran M. A Clinicopathologic Study of Oral Changes in Gastroesophageal Reflux Disease, Gastritis, and Ulcerative Colitis. J Contemp Dent Pract 2016;17(11):943-947.


Author(s):  
PAULA SANTOS FERREIRA ◽  
MARIEL RUIVO BIANCARDI ◽  
MARIA LETÍCIA LANÇA ◽  
AUDREY FOSTER LEFORT ROCHA ◽  
TULIO MORANDIN FERRISSE ◽  
...  

CHEST Journal ◽  
2007 ◽  
Vol 131 (6) ◽  
pp. 1666-1671 ◽  
Author(s):  
Robert R. Kempainen ◽  
Kay Savik ◽  
Timothy P. Whelan ◽  
Jordan M. Dunitz ◽  
Cynthia S. Herrington ◽  
...  

2020 ◽  
Vol 1 (10) ◽  
pp. 26-32
Author(s):  
L. N. Belousova ◽  
O. Yu. Chizhova ◽  
I. G. Bakulin ◽  
A. G. Sushilova

Аtrial fibrillation (AF) still occupies a special place in the structure of cardiovascular diseases, both due to its high prevalence, close association with socially significant diseases, and due to the high risks of death, stroke, and other thromboembolic complications. In turn, a patient with AF is always a comorbid patient, and among extracardiac pathology, the prevalence of diseases of the upper gastrointestinal tract, especially gastroesophageal reflux disease (GERD), pay attention. Recently more and more data have appeared that indicate the non-randomness of this combination. Many authors consider GERD as another independent risk factor for AF, while others propose to consider AF as an extra-esophageal manifestation of GERD, of course, in the absence of other cardiac risk factors. This review discusses the main pathophysiological mechanisms that determine the pathogenetic relationship of AF and GERD, known to date.


2021 ◽  
Vol 8 (1) ◽  
pp. 60-70
Author(s):  
Madalina-Gabriela Indre ◽  
Darius Sampelean ◽  
Vlad Taru ◽  
Angela Cozma ◽  
Dorel Sampelean ◽  
...  

Gastroesophageal reflux disease (GERD) is known as the most prevalent gastrointestinal disorder in the United States, leading to substantial morbidity, although associated mortality is rare. Based on the appearance of esophageal mucosa on upper endoscopy, GERD is divided into erosive esophagitis (ERD) and nonerosive reflux disease (NERD). Heartburn and acid regurgitation are the typical symptoms of the disease, although some patients may present atypical manifestations such as epigastric pain, nausea, asthma, chronic cough, pharyngitis, laryngitis, sleep disturbances, otitis, and sinusitis. Other signs, such as oral mucosal lesions may result from GERD by direct acid or acidic vapor contact in the oral cavity. Oral manifestations such as tooth erosion, periodontitis, gingivitis, palatal erythema, ulceration, glossitis, oral acid burning sensation, halitosis, xerostomia have recently been reported in GERD patients. A considerable percentage of the patients are affected by oral manifestations before the onset of gastrointestinal symptoms, although in most cases the gastrointestinal signs and symptoms dominate the clinical picture. The injured oral mucosa negatively impacts the quality of life, especially functional limitation, physical inability and psychological disabilities, thus leading to social isolation. There is plenty of non-standardized information on the oral mucosal changes in GERD. In this context, we aimed at synthesizing and analyzing the current available evidence on non-dental oral cavity lesions and complaints that are present in patients diagnosed with GERD.


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