Drugs associated with drug-induced pancreatitis: focus on rarely discussed drugs

2021 ◽  
Vol 1 (29) ◽  
pp. 33-39
Author(s):  
A. V. Filippova ◽  
E. E. Pavleeva ◽  
O. D. Ostroumova
Keyword(s):  
Central Nervous System ◽  
Acute Pancreatitis ◽  
Acute Inflammation ◽  
World Health ◽  
Antitumor Drugs ◽  
Drug Induced ◽  
The World ◽  
The Central Nervous System ◽  
Inflammatory Drugs ◽  
Health Organization

More than 500 medicines are included in the database of the World Health Organization as drugs that can cause acute inflammation of the pancreas. Drug-induced acute pancreatitis develops against the background of taking many medications (statins, antitumor drugs, drugs for the treatment of diseases of the gastrointestinal tract, analgesics and anti-inflammatory drugs, antimicrobial, antiparasitic and antiviral drugs, drugs for the treatment of tuberculosis, diseases of the central nervous system, estrogens, calcium preparations, etc.) from different classes, while the clinical picture does not differ from pancreatitis of other etiology. Based on this, it is worth paying attention to the reasons that contributed to the development of this pathology. Therefore, one of the main principles of the diagnosis of drug-induced pancreatitis is a thorough collection of a pharmacological history. If you suspect that pancreatitis was caused by a drug, you should immediately stop using it and start traditional therapeutic treatment.

Non-steroidal anti-inflammatory drugs and their effect on the nervous system: neurotoxicity, types, mechanism of occurrence

2021 ◽  
pp. 459-464
Author(s):  
Elmira Erfanovna Alimova ◽  
Elena Evgenievna Al-Rabadi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hearing Loss ◽  
Side Effects ◽  
World Health ◽  
The World ◽  
The Central Nervous System ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Health Organization

Currently, according to the World Health Organization, about 20% of the world's population takes non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs are lipophilic substances that easily penetrate the blood-brain barrier and can cause side effects from the central nervous system. Neurotoxicity (headache, dizziness, insomnia, depression, depersonalization, psychosis, and tremor occur during the treatment with indomethacin; visual impairment, drowsiness - during the treatment with meloxicam; hearing loss - when taking salicylates) ranks second after gastrotoxicity. The article describes the mechanisms of neurotoxicity that occur when taking NSAIDs.

scholarly journals Pilomyxoid Astrocytoma Occurring in the Third Ventricle

2015 ◽  
Vol 5 ◽  
pp. 41
Author(s):  
Sanghyeon Kim ◽  
Myongjin Kang ◽  
Sunseob Choi ◽  
Dae Cheol Kim
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
World Health Organization ◽  
Third Ventricle ◽  
World Health ◽  
Central Nervous System Tumor ◽  
Pilomyxoid Astrocytoma ◽  
The Third ◽  
The Central Nervous System ◽  
Health Organization

Pilomyxoid astrocytoma (PMA) is a rare central nervous system tumor that has been included in the 2007 World Health Organization Classification of Tumors of the Central Nervous System. Due to its more aggressive behavior, PMA is classified as Grade II neoplasm by the World Health Organization. PMA predominantly affects the hypothalamic/chiasmatic region and occurs in children (mean age of occurrence = 10 months). We report a case of a 24-year-old man who presented with headache, nausea, and vomiting. Brain CT and MRI revealed a mass occupying only the third ventricle. We performed partial resection. Histological findings, including monophasic growth with a myxoid background, and absence of Rosenthal fibers or eosinophilic granular bodies, as well as the strong positivity for glial fibrillary acidic protein were consistent with PMA.

The 2016 World Health Organization classification of tumours of the central nervous system

2018 ◽  
Vol 47 (11-12) ◽  
pp. e187-e200 ◽  
Author(s):  
Chiara Villa ◽  
Catherine Miquel ◽  
Dominic Mosses ◽  
Michèle Bernier ◽  
Anna Luisa Di Stefano
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
World Health Organization ◽  
World Health ◽  
World Health Organization Classification ◽  
The Central Nervous System ◽  
Health Organization
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