AUTO-SKIN TRANSPLANTATION IN DOGS

An extensive series of skin grafting operations has been performed to investigate axial organization in the regenerating axolotl limb. Semicircular cuffs of skin from either anterior, posterior, dorsal or ventral surfaces were exchanged between right and left limbs thereby creating limbs with double anterior, double posterior, double dorsal or double ventral skin, all with normal internal tissues. Both fore and hindlimbs were used at both upper and lower limb levels. Following amputation through the grafted region the resulting regenerates were analysed both by whole-mount cartilage staining to observe the pattern of digits and by serial sectioning to observe the pattern of muscles. There were clear asymmetries in ability to produce duplications - posterior to anterior grafts resulted in a consistently high frequency of digital duplications, whereas anterior to posterior grafts produced very few. Similarly, dorsal to ventral grafts resulted in a good frequency of muscle duplications, whereas ventral to dorsal grafts did not. Such asymmetrical behaviour is not predicted by most models involving local cell:cell interactions and the significance of the results for theories of pattern formation is discussed.

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THE HISTORY OF SKIN TRANSPLANTATION

History of Organ and Cell Transplantation ◽

10.1142/9781848160057_0012 ◽

2003 ◽

pp. 262-273

Author(s):

Felix T. Rapaport ◽

Jean Dausset

Keyword(s):

Skin Transplantation ◽

History Of

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Acquired tolerance of turkeys to Rous sarcoma agent

Proceedings of the Royal Society of London Series B Biological Sciences ◽

10.1098/rspb.1956.0071 ◽

1956 ◽

Vol 146 (922) ◽

pp. 59-66 ◽

Cited By ~ 17

Keyword(s):

Blood Cells ◽

Intramuscular Injection ◽

Strong Support ◽

Skin Transplantation ◽

Turkey Poult ◽

Rous Sarcoma ◽

Virus Tolerance ◽

Transplantation Antigens ◽

Intravenous Inoculation ◽

Host Component

Five- to eight-weeks old A.M.B. turkeys cannot be infected by intramuscular injection with cell-free Rous tumour agent unless they have been made tolerant by intravenous inoculation at 1 day old with whole blood or with washed blood cells from young normal chickens of the strain in which the sarcoma is usually propagated. The duration of the immunologically null period in the turkey poult has been investigated together with the specificity and stability of the tolerance-producing antigens and their relationship to skin transplantation antigens. The results afford strong support for the existence of at least one immunologically distinctive host component for the Rous agent, and this method of investigation, i.e. the production of virus tolerance in another species with identifiable antigens (possible sources of which are discussed), appears to offer an opportunity for identifying such a component or components.

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Continuous Aspirin Use Does Not Increase Bleeding Risk of Split-Thickness Skin Transplantation Repair to Chronic Wounds

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475417697652 ◽

2017 ◽

Vol 21 (4) ◽

pp. 316-319

Author(s):

Yanwei Sun ◽

Yibing Wang ◽

Liang Li ◽

Zheng Zhang ◽

Ning Wang ◽

...

Keyword(s):

Confidence Interval ◽

Odds Ratio ◽

Chronic Wounds ◽

Univariate Analysis ◽

Bleeding Risk ◽

Bleeding Complications ◽

Skin Transplantation ◽

Control Groups ◽

Thickness Skin ◽

And Control

Background: Discontinuation of aspirin therapy before cutaneous surgery may cause serious complications. Objectives: The aim of this prospective study was to evaluate the bleeding risk of split-thickness skin transplantation repair to chronic wounds in patients on aspirin therapy. Methods: A total of 97 patients who underwent split-thickness skin transplantation surgery of chronic wounds during a 2-year period were enrolled. They were categorized on the basis of aspirin therapies. The primary outcome was postoperative bleeding and bleeding complications. Univariate analysis was performed to examine the association between aspirin and bleeding complications. Among the 26 patients taking aspirin continuously in group A, there were 5 bleeding complications (19.23%). Among the 55 nonusers in group B, there were 10 bleeding complications (18.18%). Among the 16 discontinuous patients in group C, there were 3 bleeding complications (18.75%). No statistical differences were found among the groups ( P = .956). Univariate analysis showed that continuous aspirin use was not significantly associated with bleeding complications (odds ratio, 0.933; 95% confidence interval, 0.283-3.074; P = .910 in the aspirin and control groups) and that discontinuous aspirin use was not significantly associated with bleeding complications (odds ratio, 0.963; 95% confidence interval, 0.230-4.025; P = .959 in the aspirin and control groups; odds ratio, 0.969; 95% confidence interval, 0.198-4.752; P = .969 in the aspirin and discontinuous groups). Conclusions: Continuous aspirin use does not produce an additional bleeding risk in patients who undergo split-thickness skin transplantation repair of chronic wounds.

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