scholarly journals Influence of Age and Dietary Protein on Certain Free Amino Acids in Chick Blood Plasma

1963 ◽  
Vol 42 (1) ◽  
pp. 140-146 ◽  
Author(s):  
C.E. Askelson ◽  
S.L. Balloun
Keyword(s):  
Amino Acids ◽  
Blood Plasma ◽  
Dietary Protein ◽  
Free Amino Acids ◽  
Free Amino

The effect of age and dietary protein sounce on free amino acids, ammonia, and urea in the blood plasma of the calf

1966 ◽  
Vol 17 (2) ◽  
pp. 237 ◽  
Author(s):  
J Leibholz
Keyword(s):  
Amino Acids ◽  
Blood Plasma ◽  
Dietary Protein ◽  
Free Amino Acids ◽  
Free Amino ◽  
Skim Milk ◽  
Protein Supplement ◽  
Meat Meal ◽  
Methionine Concentration ◽  
Effect Of Age

The concentrations of most of the free amino acids in the blood plasma of the calf decreased with increasing age between 3 days and 24 weeks. This effect was significant for serine, proline, methionine, leucine, glutamine, lysine, and histidine while the concentrations of aspartic acid, glutamic acid, valine, cystine, and ornithine remained constant. Dried skim milk as a protein supplement in the calf's diet resulted in a higher concentration of free amino acids in the blood plasma than did meat meal. The relative proportions of the free amino acids in the plasma were related to their concentrations in the diet. Addition of methionine to calf diets increased the free methionine concentration in the blood plasma.

Dietary regulation of intestinal transport of the dipeptide carnosine

1988 ◽  
Vol 255 (2) ◽  
pp. G143-G150 ◽  
Author(s):  
R. P. Ferraris ◽  
J. Diamond ◽  
W. W. Kwan
Keyword(s):  
Amino Acids ◽  
Cell Surface ◽  
Dietary Protein ◽  
Free Amino Acids ◽  
Free Amino ◽  
Intestinal Transport ◽  
Dietary Regulation ◽  
Dietary Protein Level ◽  
Low Protein ◽  
Hydrolysis Of

Uptake of the dipeptide L-carnosine was measured in everted intestinal sleeves of mice whose dietary protein level or else proportion of protein in the form of free amino acids was varied experimentally. Carnosine uptake was highest in the jejunum, regardless of ration. Compared with a low-protein (18%) ration, a high-protein (72%) ration stimulated carnosine uptake by 30-70% in duodenum and jejunum (but not in ileum). This stimulation was observed even in the presence of peptidase inhibitors that inhibit cell surface hydrolysis of dipeptides. Measured carnosine hydrolysis was low or negligible. Carnosine uptake was the same in mice fed 54% unhydrolyzed casein, 54% partly hydrolyzed casein, and 54% free amino acids formulated so as to stimulate a complete hydrolysate of casein. Thus carnosine uptake is regulated by dietary levels of amino acids, peptides, and proteins, all of which seem equally effective at inducing carnosine transporters.

scholarly journals Possibilities for prediction of congenital fetal malformations and chromosomal abnormalities based on the determination of the levels of free amino acids and their nitrogen-containing derivatives in blood plasma of pregnant women

2020 ◽  
pp. 152-158
Author(s):  
L. N. Keda ◽  
A. V. Naumov ◽  
V. YU. Smirnov
Keyword(s):  
Amino Acids ◽  
Blood Plasma ◽  
Pregnant Women ◽  
Free Amino Acids ◽  
Free Amino ◽  
Chromosomal Abnormalities ◽  
Group I ◽  
Fetal Malformations ◽  
In Blood Plasma

Objective: to determine the possibilities for prediction and diagnosis of congenital fetal malformations and chromosomal abnormalities on the basis of the study of the levels of amino acids and their nitrogen-containing derivatives in blood plasma of pregnant women with pathological conditions requiring artificial termination of pregnancy. Material and methods. The content of free amino acids and their nitrogen-containing derivatives was studied in 104 pregnant women having congenital malformations and chromosomal abnormalities in their fetuses at 13-22 weeks` gestation (group I) and 25 women with physiological pregnancy (group II). The amino acid level was determined by the high-performance liquid chromatography method. Results. The levels of 14 out of the 26 studied amino acids in the blood plasma of the pregnant women of group I were statistically higher than those of the women in group II. ROC analysis was used to determine six amino acids (glycine, α-aminobutyric acid, hydroxylysine, glutamic acid, citrulline, serine) and their threshold values which with high accuracy (85.3 %) allow of predicting congenital fetal malformations and chromosomal abnormalities. A prognostic model making it possible to determine high probability of congenital fetal anomalies based on the determination of the concentration of 5-hydroxytryptophan, glycine, asparagine, and serine in blood plasma of pregnant women has been developed. Conclusion. The study of the levels of amino acids and their nitrogen-containing derivatives in plasma of pregnant women at 13-22 weeks` gestation can be used for prenatal diagnosis of congenital fetal malformations and chromosomal abnormalities, as well as used as an additional criterion for making the decision on the necessity for artificial termination of pregnancy upon fetal medical indications.

scholarly journals FREE AMINO ACIDS OF BLOOD PLASMA AS AN INTEGRAL PARAMETER OF METABOLIC DISORDERS IN A LONG-TERM INTAKE OF SMALL DOSES OF LEAD ACETATE INTO THE ORGANISM

2017 ◽  
pp. 67-71
Author(s):  
V. M. Sheybak ◽  
A. Y. Pavliukovets ◽  
V. Yu. Smirnov
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Blood Plasma ◽  
Free Amino Acids ◽  
Free Amino ◽  
Lead Acetate ◽  
Male Rats ◽  
Integral Parameter ◽  
In Blood Plasma

Objective: to analyze the pool of free amino acids and their nitrogen-containing metabolites of blood plasma of animals being administered lead acetate for 21 or 28 days. Material and methods. The experiments were carried out on white male rats with the initial weight of 140-160 g. During the experiment the animals received a total amount of 0.67 g of lead acetate (21 days), the second group - 1.12 g (28 days). The determination of free amino acids in blood plasma was performed by the method of reversed-phase HPLC. Results. As a result of the research it has been found out that the most significant contribution to the formation of the amino acid imbalance in blood plasma as a result of the long-term intake of lead acetate according to the value of the Fisher test is caused by changes in the concentrations of α-aminobutyric acid, isoleucine, aspartate, arginine, glycine, serine, histidine, and methionine. Conclusion. The long-term intake of lead acetate with drinking water leads to a statistically significant increase of general content of free amino acids and their nitrogen-containing metabolites, as well as to a decrease of the concentration the essential amino acid threonine in blood plasma.

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