scholarly journals THE ROLE OF CT ENTEROGRAPHY IN DIAGNOSIS OF CROHN'S DISEASE OF THE SMALL INTESTINE. REVIEW

2016 ◽  
pp. 65-74
Author(s):  
I. I. Semenova ◽  
I. V. Zarodnyuk
Keyword(s):  
Small Intestine ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Ct Enterography

scholarly journals Lipid and Bile Acid Dysmetabolism in Crohn’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Koji Uchiyama ◽  
Hisashi Kishi ◽  
Wataru Komatsu ◽  
Masanori Nagao ◽  
Shuji Ohhira ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Small Intestine ◽  
Crohn’S Disease ◽  
Bile Acid ◽  
Crohn's Disease ◽  
Terminal Ileum ◽  
Cell Function ◽  
Loss Of Function ◽  
Bile Acid Malabsorption

Crohn’s disease is one of the systemic autoimmune diseases. It commonly affects the small intestine and colon but may involve any portion of the gastrointestinal tract from the mouth to the anus. The most affected area by Crohn’s disease is the distal part of the small intestine, in which the bile acid molecules are most efficiently reabsorbed. Bile acids form mixed micelles together with fatty acids, which function as a transport vehicle to deliver fatty acids to the apical membrane of enterocytes for absorption. Therefore, if the terminal ileum is impaired, bile acid malabsorption may occur, which may cause congenital diarrhoea in Crohn’s disease. Similarly, the impairment of the terminal ileum also induces fatty acid malabsorption, which may influence the role of fatty acids in Crohn’s disease. In contrast, a recent study reported that multidrug resistance protein 1 (MDR1) regulated effector T-cell function in the ileum from bile acid-driven oxidative stress and MDR1 loss of function in a subset of patients with Crohn’s disease. However, the role of consumption of fatty acids in Crohn’s disease remains to be fully elucidated. This review is aimed at providing an overview of some recent developments in research of Crohn’s disease from comprehensive perspective with a focus on the connection between disease location and behaviour, lipid diets, and bile acid malabsorption.

Dual-energy CT enterography in evaluation of Crohn’s disease: the role of virtual monochromatic images

2020 ◽  
Author(s):  
Ezgi Guler ◽  
Nalan Gulsen Unal ◽  
Ilhan Hekimsoy ◽  
Timur Kose ◽  
Mustafa Harman ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Ct Enterography

scholarly journals Diagnostic role of computed tomography enterography (CTE) in assessment of intra-mural and extra-intestinal CT findings in active Crohn’s disease (CD)

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Rasha Mostafa Mohamed Ali ◽  
Mai Bahgat Ibrahim Ghonimy
Keyword(s):  
Computed Tomography ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Bowel Disease ◽  
Disease Process ◽  
Ct Enterography ◽  
Computed Tomography Enterography ◽  
Mucosal Thickening

Abstract Background Crohn’s disease (CD) is a ruinous bowel disease, which, if left uncured, leads to penetrating bowel complications. Computed tomography enterography (CTE) is nowadays accepted as a principal modality for the assessment of small bowel diseases. The aim of this study is to assess the role of CT enterography in the identification of intramural as well as extra-intestinal CT changes yielding more thorough data about the level and severity of the disease process thus planning appropriate treatment strategy. Results From March 2017 to January 2019, 50 patients in Cairo, Egypt, who had clinical manifestations of inflammatory bowel disease, were evaluated by MDCTE. CT image analysis was processed, including anatomical localization of bowel segments affection, assessment of mucosal thickening and hyper-enhancement, and extra-enteric affection. Diagnosis of Crohn’s disease (CD) was confirmed by endoscopy and histopathology; mucosal thickening was seen in 42 patients (84%), mucosal hyper-enhancement was seen in 44 patients (88%) while engorgement of vasa recta (comb’s sign) was seen in 38 patients (76%). Conclusion Although ileocolonoscopy is a proven sensitive method to detect mucosal injury and diagnose disease activity, it is limited by its maximal extent and inability to detect transmural complications as well as limited ability to assess deep bowel wall involvement. CT enterography (CTE) is a valuable technique in diagnostic evaluation of intramural and extra-intestinal involvement in Crohn’s disease (CD) during disease activity.

scholarly journals Can asymptomatic Chron’s disease be diagnosed in patients with iron deficiency anemia by CT-enterograhpy?

2021 ◽  
Vol 38 (SI-1) ◽  
pp. 71-73
Author(s):  
Ufuk AVCIOĞLU ◽  
Ayşegül İDİL SOYLU
Keyword(s):  
Small Intestine ◽  
Crohn’S Disease ◽  
Iron Deficiency ◽  
Crohn's Disease ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Diagnostic Utility ◽  
Pathological Findings ◽  
Ct Enterography ◽  
Chron's Disease

It is difficult to diagnose Crohn's disease in the asymptomatic period. The aim of this study is to evaluate the diagnostic utility of CT enterography (CTE) in the diagnosis of asymptomatic Crohn's disease (CD) with small intestine involment in patients with iron deficiency anemia (IDA). 250 patients who underwent CTE examination between 2017 and 2018 were retrospectively scanned. 45 patients who had endoscopic examinations and diagnosed with IDA were included in the study. While one or more pathological findings to explain IDA were observed in 31 (68%) patients with endoscopic examinations, findings that could be explained as CD sequelae were observed in 4 (8.8%) patients. No lesions were observed by CTE in 10 (22.2%) patients. Diagnosis is difficult in mild forms of Crohn’s disease or in periods of remission. In this period, CTE can contribute to the diagnosis as it can also show extraluminal findings.

scholarly journals Role of CT enterography in assessment of Crohn's disease activity: Correlation with histopathologic diagnosis

2012 ◽  
Vol 43 (3) ◽  
pp. 353-359 ◽  
Author(s):  
Ahmed Mostafa Mohamed ◽  
Sherine Kadry Amin ◽  
Maha A. El-Shinnawy ◽  
Amr Elfouly ◽  
Aber Halim Baki
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Ct Enterography ◽  
Histopathologic Diagnosis ◽  
Crohn’S Disease Activity

scholarly journals Role of video capsulе endoscopy in the diagnostic algorithm of small bowel Crohn's disease

2019 ◽  
Vol 91 (4) ◽  
pp. 37-42
Author(s):  
A I Parfenov ◽  
A O Akopova ◽  
P L Shcherbakov ◽  
O M Mikcheeva
Keyword(s):  
Small Intestine ◽  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Diagnostic Imaging ◽  
Diagnostic Algorithm ◽  
Standard Methods ◽  
Intestine Mucosa ◽  
The Mean

Aim. To evaluate the possibilities of video capsule endoscopy (VCE) for diagnosing small bowel Crohn's disease (SBCD). Materials and methods. The study included 25 patients (12 men, 13 women) diagnosed with Crohn's disease. The mean age of the patients was 31.84±10.5 years. The VCE was performed using the GivenImaging system (Yokneam, Israel), OMOM (China). After the end of each test, the data was analyzed at a rate of 8 to 10 frames per second using Rapid® Reader (version 7.0). Results and discussion. The examination of patients in accordance with the diagnostic algorithm showed that for 11 patients (44%) the clinical assumption of SBCD was confirmed only with the help of VCE (1st group). Consequently, the use of VCE in these patients was crucial in the diagnosis of SBCD, since standard methods of analisys were insufficient to establish this diagnosis. For 14 patients (2nd group), the diagnosis of SBCD was established with the help of colonoscopy and/or diagnostic imaging modalities. The use of VCE allowed to confirm the diagnosis, to clarify the localization and extent of inflammation of the small intestine. Conclusion. VCE can be recommended for the diagnosis of SBCD during the period of early inflammatory manifestations in the small intestine mucosa.

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