scholarly journals Immunomodulatory effects of HIV-1 gp120 on human dendritic cells: role of STAT3/IL-6 axis

2013 ◽  
Vol 4 ◽  
Author(s):  
Del Corn� Manuela ◽  
Donninelli Gloria ◽  
Varano Barbara ◽  
Masotti Andrea ◽  
Da Sacco Letizia ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Immunomodulatory Effects ◽  
Human Dendritic Cells ◽  
Hiv 1

scholarly journals The Role of Human Dendritic Cells in HIV-1 Infection

2015 ◽  
Vol 135 (5) ◽  
pp. 1225-1233 ◽  
Author(s):  
Zahra Ahmed ◽  
Tatsuyoshi Kawamura ◽  
Shinji Shimada ◽  
Vincent Piguet
Keyword(s):  
Dendritic Cells ◽  
Human Dendritic Cells ◽  
Hiv 1

Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2–dependent regulatory dendritic cell population

Blood ◽  
2009 ◽  
Vol 113 (1) ◽  
pp. 46-57 ◽  
Author(s):  
Bin Zhang ◽  
Rui Liu ◽  
Dan Shi ◽  
Xingxia Liu ◽  
Yuan Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dendritic Cells ◽  
Immune Cells ◽  
Cell Contact ◽  
Multilineage Differentiation ◽  
Immunomodulatory Effects ◽  
Cd11b Expression ◽  
Dendritic Cell Population

Abstract Mesenchymal stem cells (MSCs), in addition to their multilineage differentiation, exert immunomodulatory effects on immune cells, even dendritic cells (DCs). However, whether they influence the destiny of full mature DCs (maDCs) remains controversial. Here we report that MSCs vigorously promote proliferation of maDCs, significantly reduce their expression of Ia, CD11c, CD80, CD86, and CD40 while increasing CD11b expression. Interestingly, though these phenotypes clearly suggest their skew to immature status, bacterial lipopolysaccharide (LPS) stimulation could not reverse this trend. Moreover, high endocytosic capacity, low immunogenicity, and strong immunoregulatory function of MSC-treated maDCs (MSC-DCs) were also observed. Furthermore we found that MSCs, partly via cell-cell contact, drive maDCs to differentiate into a novel Jagged-2–dependent regulatory DC population and escape their apoptotic fate. These results further support the role of MSCs in preventing rejection in organ transplantation and treatment of autoimmune disease.

scholarly journals Expression and a role of functionally coupled P2Y receptors in human dendritic cells

FEBS Letters ◽  
1999 ◽  
Vol 445 (2-3) ◽  
pp. 402-408 ◽  
Author(s):  
Q.H. Liu ◽  
H. Bohlen ◽  
S. Titzer ◽  
O. Christensen ◽  
V. Diehl ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
P2y Receptors ◽  
Human Dendritic Cells

scholarly journals Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma

Blood ◽  
2008 ◽  
Vol 112 (7) ◽  
pp. 2878-2885 ◽  
Author(s):  
Kavita M. Dhodapkar ◽  
Scott Barbuto ◽  
Phillip Matthews ◽  
Anjli Kukreja ◽  
Amitabha Mazumder ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Th17 Cells ◽  
T Helper ◽  
Tumor Bed ◽  
Distinct Lineage ◽  
Human Dendritic Cells ◽  
Antigen Presenting ◽  
Dc Maturation

Abstract IL17-producing (Th17) cells are a distinct lineage of T helper cells that regulate immunity and inflammation. The role of antigen-presenting cells in the induction of Th17 cells in humans remains to be fully defined. Here, we show that human dendritic cells (DCs) are efficient inducers of Th17 cells in culture, including antigen-specific Th17 cells. Although most freshly isolated circulating human Th17 cells secrete IL17 alone or with IL2, those induced by DCs are polyfunctional and coexpress IL17 and IFNγ (Th17-1 cells). The capacity of DCs to expand Th17-1 cells is enhanced upon DC maturation, and mature DCs are superior to monocytes for the expansion of autologous Th17 cells. In myeloma, where tumors are infiltrated by DCs, Th17 cells are enriched in the bone marrow relative to circulation. Bone marrow from patients with myeloma contains a higher proportion of Th17-1 cells compared with the marrow in preneoplastic gammopathy (monoclonal gammopathy of undetermined significance [MGUS]). Uptake of apoptotic but not necrotic myeloma tumor cells by DCs leads to enhanced induction of Th17-1 cells. These data demonstrate the capacity of DCs to induce expansion of polyfunctional IL17-producing T cells in humans, and suggest a role for DCs in the enrichment of Th17-1 cells in the tumor bed.

scholarly journals Cocoa procyanidins modulate transcriptional pathways linked to inflammation and metabolism in human dendritic cells

2018 ◽  
Vol 9 (5) ◽  
pp. 2883-2890 ◽  
Author(s):  
Helene L. E. Midttun ◽  
Aina Ramsay ◽  
Irene Mueller-Harvey ◽  
Andrew R. Williams
Keyword(s):  
Dendritic Cells ◽  
Immunomodulatory Effects ◽  
Cocoa Beans ◽  
Mechanistic Insight ◽  
Human Dendritic Cells ◽  
Insight Into

A mechanistic insight into the immunomodulatory effects of a purified procyanidin fraction from cocoa beans.

scholarly journals Novel dual role of dendritic cells in priming de novo CTL responses while inhibiting memory CTL responses to HIV-1 through the PD-L1 pathway

2017 ◽  
Vol 3 ◽  
pp. 36
Author(s):  
T.M. Garcia-Bates ◽  
M. Palma ◽  
B. Macatangay ◽  
C. Rinaldo ◽  
R. Mailliard
Keyword(s):  
Dendritic Cells ◽  
De Novo ◽  
Dual Role ◽  
Hiv 1 ◽  
Ctl Responses

scholarly journals Apoptotic microparticles generated during acute HIV-1 infection inhibit human dendritic cells via CD44

Retrovirology ◽  
2012 ◽  
Vol 9 (S2) ◽  
Author(s):  
D Frleta ◽  
CE Ochoa ◽  
HB Kramer ◽  
SA Khan ◽  
AR Stacey ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Acute Hiv ◽  
Human Dendritic Cells ◽  
Hiv 1
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