scholarly journals Combined Signature of the Urinary Microbiome and Metabolome in Patients With Interstitial Cystitis

2021 ◽  
Vol 11 ◽  
Author(s):  
Hewei Xu ◽  
Nebiyu Elias Tamrat ◽  
Jie Gao ◽  
Jie Xu ◽  
Yiduo Zhou ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Fatty Acid Biosynthesis ◽  
Opportunistic Pathogen ◽  
Clinical Syndrome ◽  
Diagnostic Markers ◽  
Metabolome Analysis ◽  
Control Groups ◽  
16S Rrna Sequence ◽  
Bladder Pain ◽  
Urinary Microbiome

Interstitial cystitis (IC) is a clinical syndrome characterized by frequency, urgency, and bladder pain or pelvic pain; however, the underlying pathophysiological mechanisms and diagnostic markers are unknown. In this study, microbiome and metabolome analysis were used to explain the urine signatures of IC patients. Urine samples from 20 IC patients and 22 control groups were analyzed by using 16S rRNA sequence and liquid chromatography coupled with mass spectrometry. Four opportunistic pathogen genera, including Serratia, Brevibacterium, Porphyromonas, and Citrobacter, were significantly upregulated in IC group. The altered metabolite signatures of the metabolome may be related to sphingosine metabolism, amino acid metabolism, and fatty acid biosynthesis. Meanwhile, the associations were observed between different metabolites and microbiomes of IC. The present study suggests that the combined signatures of IC in urine microbiome and metabolome may become its prospective diagnostic markers.

scholarly journals Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infection and the potential role of the urinary microbiome

2020 ◽  
Vol 26 (2) ◽  
pp. 87-90
Author(s):  
Alka Bhide ◽  
Visha Tailor ◽  
Vik Khullar
Keyword(s):  
Urinary Tract ◽  
Interstitial Cystitis ◽  
Urinary Tract Infections ◽  
Potential Role ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Bladder Pain ◽  
Urinary Microbiome ◽  
Tract Infections

Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infections carry significant burden for those affected. As women enter the menopause, other factors may influence how these conditions manifest. The urinary microbiome has shown that the urine contains extensive numbers of bacteria. There is some evidence to suggest that it is altered depending on the menopausal state of the individual. It is possible that this alteration may go on to influence how the disease course of interstitial cystitis/bladder pain syndrome and recurrent urinary tract infections runs in the post-menopausal group. The review will explore these two conditions and the potential role of the urinary microbiome.

The Bladder Pain/Interstitial Cystitis Symptom Score: Development, Validation, and Identification of a Cut Score

2012 ◽  
Vol 61 (2) ◽  
pp. 271-279 ◽  
Author(s):  
Louise Humphrey ◽  
Rob Arbuckle ◽  
Rob Moldwin ◽  
Jorgen Nordling ◽  
Joop P. van de Merwe ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Symptom Score ◽  
Bladder Pain ◽  
Cut Score
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