Editorial: Applications of Next Generation Sequencing (NGS) Technologies to Decipher the Oral Microbiome in Systemic Health and Disease

A breakthrough in next generation sequencing (NGS) in the last decade provided an unprecedented opportunity to investigate genetic variations in humans and their roles in health and disease.

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Is Next-Generation Sequencing Appropriate for the Clinic?

University of Ottawa Journal of Medicine ◽

10.18192/uojm.v4i2.1075 ◽

2014 ◽

Vol 4 (2) ◽

pp. 45-48

Author(s):

Ramzi Hassouneh

Keyword(s):

Next Generation Sequencing ◽

Low Cost ◽

Genomic Medicine ◽

Clinical Applications ◽

Next Generation ◽

Apply Genetic ◽

Health And Disease ◽

Next Generation Sequencing Ngs ◽

The Impact ◽

Generation Sequencing

Next-generation sequencing (NGS) has ignited a revolution in genomic medicine by eliminating the inherent limitations of conventional sequencing methods. Due to its high throughput and low-cost, clinics can use NGS to perform targeted and genome sequencing to make diagnoses or pre-screen for risk to future disease. Despite its clinical uses, many challenges exist before NGS becomes a mainstay in the clinic. There is a lack of understanding of the impact of genetic variants on health and disease and how to best apply genetic information to patient care. Nevertheless, the translation of base pair reads to clinical applications has truly begun.

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Identification of new familial pheochromocytoma/paraganglioma genes using next generation sequencing (NGS)

Endocrine Abstracts ◽

10.1530/endoabs.40.l12 ◽

2016 ◽

Author(s):

Alberto Cascon

Keyword(s):

Next Generation Sequencing ◽

Next Generation ◽

Familial Pheochromocytoma ◽

Next Generation Sequencing Ngs ◽

Generation Sequencing

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Difference in plasma miRNA levels in inferior petrosal sinus samples from patients with ACTH-dependent Cushing’s syndrome as assessed by next-generation sequencing (NGS).

Endocrine Abstracts ◽

10.1530/endoabs.70.aep569 ◽

2020 ◽

Author(s):

Zhanna Belaya ◽

Anastasia Malygina ◽

Alexey Nikitin ◽

Philipp Koshkin ◽

Ivan Sitkin ◽

...

Keyword(s):

Next Generation Sequencing ◽

Cushing’S Syndrome ◽

Cushing's Syndrome ◽

Inferior Petrosal Sinus ◽

Next Generation ◽

Next Generation Sequencing Ngs ◽

Plasma Mirna ◽

Generation Sequencing

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Comprehensive comparison of trophectoderm (TE) and inner cell mass (ICM) by next generation sequencing (NGS)

10.26226/morressier.5af300b2738ab10027aa98b3 ◽

2018 ◽

Author(s):

Ibrahim Elkhatib ◽

Ibrahim ['Alberto']

Keyword(s):

Next Generation Sequencing ◽

Inner Cell Mass ◽

Cell Mass ◽

Next Generation ◽

Comprehensive Comparison ◽

Next Generation Sequencing Ngs ◽

Generation Sequencing

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Next-generation sequencing (NGS) based preimplantation genetic testing for products of reciprocal translocation (PGT-TR) improves diagnosis of the patients by verification of their classical karyotyping results.

10.26226/morressier.5af300b2738ab10027aa98a4 ◽

2018 ◽

Author(s):

Sebastian Pukszta

Keyword(s):

Genetic Testing ◽

Next Generation Sequencing ◽

Reciprocal Translocation ◽

Next Generation ◽

Preimplantation Genetic Testing ◽

Next Generation Sequencing Ngs ◽

Generation Sequencing

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Initial Next-Generation Sequencing (NGS) Results of Alport Syndrome

Journal of Basic and Clinical Health Sciences ◽

10.30621/jbachs.2019.719 ◽

2019 ◽

Author(s):

Altuğ Koç ◽

Elçin Bora ◽

Tayfun Cinleti ◽

Gizem Yıldız ◽

Meral Torun Bayram ◽

...

Keyword(s):

Next Generation Sequencing ◽

Alport Syndrome ◽

Next Generation ◽

Next Generation Sequencing Ngs ◽

Generation Sequencing

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Next Generation Sequencing（NGS）Monitors Minimal Residual Disease（MRD）in Allo-PBSCT Patients

Case Medical Research ◽

10.31525/ct1-nct04126967 ◽

2019 ◽

Author(s):

Keyword(s):

Next Generation Sequencing ◽

Minimal Residual Disease ◽

Residual Disease ◽

Next Generation ◽

Next Generation Sequencing Ngs ◽

Generation Sequencing ◽

Minimal Residual

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The applications of next-generation sequencing (NGS) in drug development for cancer therapy

Current Analytical Chemistry ◽

10.2174/1573411016999200626193227 ◽

2020 ◽

Vol 16 ◽

Author(s):

Pelin Telkoparan-Akillilar ◽

Dilek Cevik

Keyword(s):

Next Generation Sequencing ◽

Drug Discovery ◽

Cancer Therapy ◽

Target Identification ◽

Rapid Development ◽

Next Generation ◽

Biomedical Sciences ◽

Dna And Rna ◽

Next Generation Sequencing Ngs ◽

Generation Sequencing

Background: Numerous sequencing techniques have been progressed since the 1960s with the rapid development of molecular biology studies focusing on DNA and RNA. Methods: a great number of articles, book chapters, websites are reviewed, and the studies covering NGS history, technology and applications to cancer therapy are included in the present article. Results: High throughput next-generation sequencing (NGS) technologies offer many advantages over classical Sanger sequencing with decreasing cost per base and increasing sequencing efficiency. NGS technologies are combined with bioinformatics software to sequence genomes to be used in diagnostics, transcriptomics, epidemiologic and clinical trials in biomedical sciences. The NGS technology has also been successfully used in drug discovery for the treatment of different cancer types. Conclusion: This review focuses on current and potential applications of NGS in various stages of drug discovery process, from target identification through to personalized medicine.

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