First Case of Mature Teratoma and Yolk Sac Testis Tumor Associated to Inherited MEN-1 Syndrome

✓ The recurrence of intracranial mature teratomas as germ cell tumors of different histological types is rarely reported. The authors describe the first case of the malignant transformation of an intracranial mature teratoma into a yolk sac tumor in a 16-year-old boy who presented with a 1-month history of anorexia and somnolence. Seven years prior to this presentation, the boy had undergone surgery for extirpation of a mature pineal teratoma. Computed tomography images obtained at his second presentation revealed a homogeneously enhanced mass within the third ventricle. The tumor was resected and the results of a histological examination were consistent with a yolk sac tumor. After resection, the patient underwent radiation therapy followed by chemotherapy with cisplatin and etoposide but died of tumor progression 15 months after his second hospitalization.

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Fetus in fetu: two case reports from North African country

Egyptian Pediatric Association Gazette ◽

10.1186/s43054-020-00049-5 ◽

2021 ◽

Vol 69 (1) ◽

Author(s):

Moutaz Ragab ◽

Omar Nagy Abdelhakeem ◽

Omar Mansour ◽

Mai Gad ◽

Hesham Anwar Hussein

Keyword(s):

Histopathological Examination ◽

Case Reports ◽

Abdominal Mass ◽

Mature Teratoma ◽

Surgical Techniques ◽

Rare Condition ◽

Mass Effect ◽

Fetus In Fetu ◽

Vascular Connection ◽

First Case

Abstract Background Fetus in fetu is a rare congenital anomaly. The exact etiology is unclear; one of the mostly accepted theories is the occurrence of an embryological insult occurring in a diamniotic monochorionic twin leading to asymmetrical division of the blastocyst mass. Commonly, they present in the infancy with clinical picture related to their mass effect. About 80% of cases are in the abdomen retroperitoneally. Case presentation We present two cases of this rare condition. The first case was for a 10-year-old girl that presented with anemia and abdominal mass, while the second case was for a 4-month-old boy that was diagnosed antenatally by ultrasound. Both cases had vertebrae, recognizable fetal organs, and skin coverage. Both had a distinct sac. The second case had a vascular connection with the host arising from the superior mesenteric artery. Both cases were intra-abdominal and showed normal levels of alpha-fetoprotein. Histopathological examination revealed elements from the three germ layers without any evidence of immature cells ruling out teratoma as a differential diagnosis. Conclusions Owing to its rarity, fetus in fetu requires a high degree of suspicion and meticulous surgical techniques to avoid either injury of the adjacent vital structures or bleeding from the main blood supply connection to the host. It should be differentiated from mature teratoma.

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Mature Teratoma in a Supernumerary Ovary in a Child: Report of the First Case

Journal of Pediatric and Adolescent Gynecology ◽

10.1016/j.jpag.2015.07.005 ◽

2016 ◽

Vol 29 (1) ◽

pp. e5-e7 ◽

Cited By ~ 4

Author(s):

Ruchika Gupta ◽

Sarika Verma ◽

Kalpana Bansal ◽

Vishesh Jain ◽

Mamta Sengar ◽

...

Keyword(s):

Mature Teratoma ◽

Child Report ◽

First Case

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Simultaneous intracranial and testicular germ cell tumors: illustrative case

Journal of Neurosurgery: Case Lessons ◽

10.3171/case2067 ◽

2021 ◽

Vol 1 (3) ◽

Author(s):

Lei Han ◽

Jie Lu ◽

Luxiong Fang ◽

Songtao Qi ◽

Ye Song

Keyword(s):

Germ Cell ◽

Mature Teratoma ◽

Germ Cell Tumors ◽

Testicular Tumor ◽

Cystic Teratoma ◽

Pineal Region ◽

Illustrative Case ◽

Testicular Germ Cell Tumors ◽

Testicular Germ Cell ◽

First Case

BACKGROUNDSimultaneous intracranial and testicular germ cell tumors (GCTs) are extremely rare, leading to a lack of adequate experience in their treatment. Therefore, the authors report a case of this kind of GCT.OBSERVATIONSA 5-year-old boy was admitted to the hospital with headache and vomiting. Computed tomography and magnetic resonance imaging suggested the possibility of a GCT in the pineal region. The value of the serum tumor marker alpha-fetoprotein (AFP) was 5,396.1 μg/L, and β-human chorionic gonadotropin levels were within the normal range. Subsequently, the tumor was removed, and the final pathological result was a mixed GCT. Therefore, chemotherapy and radiation were added. However, the authors found a testicular tumor on ultrasound at the same time, and pathology after surgery suggested a mature cystic teratoma. Following treatment, the patient recovered well, and AFP levels dropped to normal values.LESSONSTo the authors’ knowledge, this report is the fourth case of simultaneous intracranial and testicular GCTs and the first case of a simultaneous mixed GCT in the pineal region and mature teratoma of the testis. A combination of surgery, chemotherapy, and radiation therapy for mixed GCTs in the pineal region and surgical excision for testicular reproductive cell tumors are effective in these patients, but long-term monitoring is required.

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Duodenal mature teratoma causing partial intestinal obstruction: A first case report in an adult

World Journal of Clinical Cases ◽

10.12998/wjcc.v8.i8.1489 ◽

2020 ◽

Vol 8 (8) ◽

pp. 1489-1494

Author(s):

Tharintorn Chansoon ◽

Napat Angkathunyakul ◽

Rangsima Aroonroch ◽

Jakrapan Jirasiritham

Keyword(s):

Case Report ◽

Intestinal Obstruction ◽

Mature Teratoma ◽

First Case ◽

Partial Intestinal Obstruction

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MIXED GERM TUMOR WITH YOLK SAC TUMOR AND MATURE TERATOMA - CASE REPORT AND LITERATURE REVIEW

10.26226/morressier.5d2ee8ea1e09a6f49485abb1 ◽

2019 ◽

Author(s):

Ketheryn Almeida ◽

GUSTAVO CARVALHO ◽

JOSE LUIS BRAVIN ◽

Maria Inês Pereira da Silva Vianna ◽

Vinicius Vicuna ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Mature Teratoma ◽

Yolk Sac ◽

Yolk Sac Tumor

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Ovarian Germ Cell Tumor with Myasthenia Gravis: Co-incidence or a Possible link?

Asian Pacific Journal of Cancer Care ◽

10.31557/apjcc.2021.6.4.525-527 ◽

2021 ◽

Vol 6 (4) ◽

pp. 525-527

Author(s):

Jhanzeb Iftikhar ◽

Fareeha Sheikh ◽

Nazish Khalid ◽

Muhammad Abubakar Sarwar ◽

Musa Azhar ◽

...

Keyword(s):

Myasthenia Gravis ◽

Germ Cell ◽

Germ Cell Tumor ◽

Mature Teratoma ◽

Surgical Excision ◽

Cell Tumor ◽

Ovarian Teratoma ◽

First Case ◽

Complete Surgical Excision ◽

Ovarian Teratomas

Teratomas are a common form of germ cell tumor. Teratomas are commonly found in the gonadal organs, such as the ovaries and testes. Treatment of choice for ovarian teratomas is complete surgical excision, which exhibits a good prognosis in benign teratomas; however, chemotherapy treatment is needed for malignant components. Neurological paraneoplastic presentation of gynecological tumors is rare; however, ovarian tumors account for 10% of this presentation. In literature, paraneoplastic limbic encephalitis, anti-N-methyl-D-aspartate receptor encephalitis, and paraneoplastic cerebellar degeneration have been reported in ovarian teratomas and tumors; however, myasthenia gravis has been reported only twice. In both of those cases, manifestation of myasthenia gravis was preceding the diagnosis of ovarian cancer. We describe the first case of a 21-year-old female who presented with new-onset myasthenia gravis after finishing chemotherapy for ovarian teratoma. Another unusual aspect of our case is the rare co-occurrence of gliomatosis peritonei with mature teratoma.

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P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma

Case Reports in Obstetrics and Gynecology ◽

10.1155/2020/8863610 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Sarah Bouri ◽

Philippe Simon ◽

Nicky D’Haene ◽

Xavier Catteau ◽

Jean-Christophe Noël

Keyword(s):

Recurrent Disease ◽

Mature Teratoma ◽

Mucinous Carcinoma ◽

Intestinal Type ◽

Molecular Profile ◽

Pik3ca Mutations ◽

First Case ◽

Therapeutic Outcomes ◽

Generation Sequencing ◽

P53 Genes

Primary ovarian intestinal-type mucinous carcinomas associated with mature teratoma are rare and represent less than 3% of all primary ovarian neoplasms. The molecular profile of these tumors is still controversial. We report here the first case of mucinous ovarian tumor in which mutation of the PIK3CA and P53 genes could be demonstrated by the next generation sequencing technique without KRAS mutation or HER2 amplification. Our data suggest that these mucinous carcinoma variants probably present an extremely complex molecular biology profile that should be known in the future to stratify therapeutic outcomes and potential targeted therapies, particularly in recurrent disease.

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